Human placental extract has been used to treat fatigue, postmenopausal symptoms, wound healing, and growth retardation in Korea. Combined with acupuncture therapy, placental extract extends its therapeutic limit to pain control. Recently, we have reported acupuncture point injection (API) with placental extract modulated inflammationinvolving pain symptoms in chronic pain diseases. In order to rehabilitate patients suffering from chronic pain and restricted joint mobility, placental extract was injected into acupuncture points localized on the joints, surrounding muscles acting in concert with the joints, and paravertebral muscles affecting the innervation of the joints. Here, we describe the pathology of pain syndromes including neck pain, back pain, shoulder pain, knee arthritis, fibromyalgia, and complex regional pain syndrome and propose methodology of APIs with placental extract in treating these pain diseases.