2023
DOI: 10.7554/elife.80808
|View full text |Cite
|
Sign up to set email alerts
|

eDNA-stimulated cell dispersion from Caulobacter crescentus biofilms upon oxygen limitation is dependent on a toxin–antitoxin system

Abstract: In their natural environment, most bacteria preferentially live as complex surface-attached multicellular colonies called biofilms. Biofilms begin with a few cells adhering to a surface, where they multiply to form a mature colony. When conditions deteriorate, cells can leave the biofilm. This dispersion is thought to be an important process that modifies the overall biofilm architecture and that promotes colonization of new environments. In Caulobacter crescentus biofilms, extracellular DNA (eDNA) is released… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(3 citation statements)
references
References 98 publications
0
3
0
Order By: Relevance
“…In addition, CcdAB, PemK and Hok-Sok were also observed in AL74 strain; together with VagCD, those three PAS have been reported to be the most representative in clinical samples related to the spread of β-lactamases [51]; however, in two of our clinical samples we did not observe VagCD. ParDE has been found to help modulate the stress response during antimicrobial treatment, confer protection against DNA damage or loss and induce bacterial tolerance [52], which is important in the survival of bacterial biofilms in Caulobacter crescentus [53], plasmids related to these PAS might be involved in environmental tolerance and pathogenic potential of L. adecarboxylata .…”
Section: Discussionmentioning
confidence: 99%
“…In addition, CcdAB, PemK and Hok-Sok were also observed in AL74 strain; together with VagCD, those three PAS have been reported to be the most representative in clinical samples related to the spread of β-lactamases [51]; however, in two of our clinical samples we did not observe VagCD. ParDE has been found to help modulate the stress response during antimicrobial treatment, confer protection against DNA damage or loss and induce bacterial tolerance [52], which is important in the survival of bacterial biofilms in Caulobacter crescentus [53], plasmids related to these PAS might be involved in environmental tolerance and pathogenic potential of L. adecarboxylata .…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, yefM - yoeB inhibited biofilm formation in Edwardsiella piscicida [ 59 ], and overexpression of toxins resembling RelE and VapC in Burkholderia cenocepacia showed a positive effect on biofilm formation [ 78 ]. In addition, ectopic expression of parDE TA promoted biofilm formation in E. coli [ 54 ], and deletion of parDE in Caulobacter crescentus increased biofilm formation [ 79 ].…”
Section: Putative Ta Roles In Aiec’s Pathogenesismentioning
confidence: 99%
“…In Staphylococcus aureus , deletion of the mazF type II toxin gene also caused increased biofilm formation and higher sensitivity to antibiotic treatment ( 25 ). In Caulobacter crescentus , a ParDE 4 TA system is activated upon O 2 limitation and enhances eDNA-stimulated dispersal from its biofilm, perhaps to seek out a more favorable situation ( 26 ). Interestingly, the antitoxin’s DNA-binding domain not only binds to its own promoter region, particularly when complexed with its cognate toxin ( 27 , 28 ), but also can bind to and regulate distal promoters ( 22 , 29 , 30 ).…”
Section: Introductionmentioning
confidence: 99%