EDUC’AVK: Reduction of Oral Anticoagulant-related Adverse Events After Patient Education: A Prospective Multicenter Open Randomized Study

Pernod, Gilles; Labarère, José; Yver, J; Satger, B.; Allenet, Benoît; Berremili, Touffek; Fontaine, Mathieu; Franco, Guy; Bosson, Jean Luc

doi:10.1007/s11606-008-0690-1

Cited by 77 publications

(67 citation statements)

References 28 publications

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“…In pooling data from three of the studies that reported clinical outcomes in a similar manner, there was no signifi cant difference between supplemental patient education and usual care (VTE RR, 0.61 [95% CI, 0.06-6.56]; hemorrhage RR, 0.92 [95% CI, 0.04-20.56]). 210,212,213 TTR was reported in four trials and was similar between groups (mean difference, 2.03%; 95% CI, 2 2.79-6.86). [210][211][212]214 In the single study where the difference in intensity of education was marked (described as minimal vs daily intensive education for mean of 8 days), there was no difference in outcomes, including TTR.…”

Section: Intensive Patient Education and Anticoagulation Outcomesmentioning

confidence: 68%

“…208,209 Seven RCTs (n 5 1,195) compared supplemental patient education with usual care and provided some data on clinical outcomes. [210][211][212][213][214][215][216] Patient age varied widely (18-91 years), and the indications for VKA therapy included atrial fi brillation and VTE. Six of the studies were based in anticoagulation clinics.…”

Section: Intensive Patient Education and Anticoagulation Outcomesmentioning

confidence: 99%

“…215,216 Others had repeated interaction with patients at daily intervals on a ward until discharge or at weekly or bimonthly intervals in outpatient clinics. 210,212,213 The curricula covered similar content, including indications for VKAs, benefi ts and risks, the importance of INR surveillance, drug interactions, the effect of diet, and information on dose management. The amount and type of education in the control arms were unclear.…”

Section: Intensive Patient Education and Anticoagulation Outcomesmentioning

confidence: 99%

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Evidence-Based Management of Anticoagulant Therapy

Holbrook

Schulman

Witt

et al. 2012

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Section: Intensive Patient Education and Anticoagulation Outcomesmentioning

confidence: 68%

Section: Intensive Patient Education and Anticoagulation Outcomesmentioning

confidence: 99%

Section: Intensive Patient Education and Anticoagulation Outcomesmentioning

confidence: 99%

See 1 more Smart Citation

Evidence-Based Management of Anticoagulant Therapy

Holbrook

Schulman

Witt

et al. 2012

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1,097

353

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“…Le plus souvent, l'évalua-tion du dispositif d'éducation thérapeutique (séances individuelles associées à une prise en charge particulière comme une autosurveillance des INR, un suivi des INR par un centre expert) est envisagé sans pouvoir distinguer l'impact des différentes interventions éducatives réalisées. [15]. La diminution du risque est observée quels que soient l'âge, le niveau d'étude (obtention du baccalauréat ou non) ou le type de prise en charge hospitalière ou libérale ( figure 1 et figure 2).…”

Section: Points Essentielsunclassified

Éducation thérapeutique des patients traités par anticoagulants oraux antivitamines K

Satger¹,

Blaise²,

Fontaine³

et al. 2009

La Presse Médicale

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“…A relação entre o conhecimento sobre esses medicamentos e o controle da coagulação tem sido objeto de vários estudos (DAVIS et al, 2005;KHAN et al 2004;PERNOD et al, 2008;TANG et al, 2003;VOLLER et al, 2004). Atualmente, sabemos que simplesmente informar ao paciente sobre o que deve ser feito é insuficiente para produzir mudança de comportamento e incentivar a adesão ao medicamento.…”

Section: Programas Educativos Para Indivíduos Em Uso De Anticoagulaçãunclassified

Efeitos de um programa educativo na qualidade de vida relacionada à saúde e na adesão à terapia de anticoagulação oral: estudo clínico randomizado

Corbi¹

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DEDICATÓRIAExperimental study with random distribution in two groups (Intervention or Control), which assessed the health-related quality of life and medication treatment adherence of patients who were hospitalized to adjust the oral anticoagulation drug dosage, according to their participation in an educational group (Intervention Group -IG) or in routine care (Control Group -CG). The groups were also compared according to their general self-efficacy and presence of anxiety and depression symptoms at two times: upon hospitalization (T 1 ) and two months after discharge from hospital (T 2 ). The study was developed at a public hospital in the interior of São Paulo State, Brazil, from March 2011 till December 2012. In total, 113 patients were considered eligible for the study, randomized between CG (N=58) and IG (N=55). The randomization took place after the patients' stratification into low, medium and high bleeding risk, according to The Outpatient Bleeding Risk Index. The patients who participated in the educative program received individualized orientations, using illustrative material, during the hospitalization. After discharge, the orientations were provided through telephone contact during the first and fourth week. To assess the research variables, the versions of the Duke Anticoagulation Satisfaction Scale, Treatment Adherence Measures, Hospital Anxiety and Depression Scale and General Perceived Self-Efficacy Scale validated for Brazilian Portuguese were used. After two months of monitoring, 44 participants completed the followup in CG (75.8% of participants at T 1 ) and 38 in IG (69.1%). The data were assessed by means of descriptive statistics and comparison of means for the variables of interest between the groups (independent Student's t) and intra-groups (paired Student's t-test), upon the hospitalization and two months after discharge. The significance level adopted was 0.05. When comparing the patient groups that completed the follow-up or not, we found similarities in sociodemographic and clinical variables and related to the oral anticoagulation therapy. These similarities were also observed when comparing the control and intervention groups during the hospitalization. As regards the health-related quality of life, treatment adherence, anxiety and depression symptoms and self-efficacy, the results reveal similarities between CG and IG at T 1 and T 2 , not confirming our study hypotheses for T 2 . At T 2 , the differences in the HRQoL (p=0.65), adherence (p=0.89), anxiety (p=0.20), depression (p=0.27) and selfefficacy (p=0.65) scores could not be confirmed when considering the participation in the educative program. In view of the results obtained in the present study, we conclude that, for patients with previous experience in oral anticoagulation treatment, the educative strategy used was not efficient to improve the selected response variables. From the clinical viewpoint, this result is relevant for the health professionals who deliver care to this population of oral anticoagulation drug user...

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EDUC’AVK: Reduction of Oral Anticoagulant-related Adverse Events After Patient Education: A Prospective Multicenter Open Randomized Study

Cited by 77 publications

References 28 publications

Evidence-Based Management of Anticoagulant Therapy

Evidence-Based Management of Anticoagulant Therapy

Éducation thérapeutique des patients traités par anticoagulants oraux antivitamines K

Efeitos de um programa educativo na qualidade de vida relacionada à saúde e na adesão à terapia de anticoagulação oral: estudo clínico randomizado

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