The impetus for nations to build resilience for rapid changes and uncertainty, and the increasing complexity of challenges has made sustainable development a priority. Lifelong learning holds the key to sustainability in maximizing human potential to address the needs of the future. The development of the science of lifelong learning is emerging and gaining traction through interdisciplinary discourse and research. It has provided a framework to view lifelong learning from cradle to grave with foundations in our understanding of brain development, degeneration, and plasticity . The space for lifelong learning is interactive, life-wide and entrenched in rich social contexts. Thus, the translation of scientific knowledge (including neuroscience) to be consumable by the masses (the learners), and the agents providing knowledge (the educators and parents), will be instrumental in promoting inclusive and participatory processes of knowledge production and sharing. We envision the science of lifelong learning to empower learners from diverse backgrounds and societies to have the capacity to contribute to a learning planet. This chapter provides a brief overview of the current state of the science of lifelong learning. We will showcase some ongoing research on the science of learning at our centre in Singapore and discuss implications of lifelong learning for futures of education, economy, health, and well-being.