EEG Correlation of the Discharge Properties of Identified Neurons in the Basal Forebrain

Duque, Alvaro; Balatoni, Balázs; Détári, László; Záborszky, László

doi:10.1152/jn.2000.84.3.1627

Cited by 163 publications

(151 citation statements)

References 47 publications

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“…Although other parts of the ARAS, such as the thalamus (3), likely are important, our results suggest that BF PV neurons are involved in state-dependent control of GBO. Juxtacellularly identified BF PV neurons in anesthetized rats increased their firing rate with cortical activation caused by tail pinch (23). Our preliminary recordings from two optically identified BF PV neurons in mice confirmed that their discharge is highest in states that show more GBO activity, i.e., wakefulness and REM sleep.…”

Section: Discussionsupporting

confidence: 68%

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Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations

Kim

Thankachan

Mckenna

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

267

256

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Cortical gamma band oscillations (GBO, 30–80 Hz, typically ∼40 Hz) are involved in higher cognitive functions such as feature binding, attention, and working memory. GBO abnormalities are a feature of several neuropsychiatric disorders associated with dysfunction of cortical fast-spiking interneurons containing the calcium-binding protein parvalbumin (PV). GBO vary according to the state of arousal, are modulated by attention, and are correlated with conscious awareness. However, the subcortical cell types underlying the state-dependent control of GBO are not well understood. Here we tested the role of one cell type in the wakefulness-promoting basal forebrain (BF) region, cortically projecting GABAergic neurons containing PV, whose virally transduced fibers we found apposed cortical PV interneurons involved in generating GBO. Optogenetic stimulation of BF PV neurons in mice preferentially increased cortical GBO power by entraining a cortical oscillator with a resonant frequency of ∼40 Hz, as revealed by analysis of both rhythmic and nonrhythmic BF PV stimulation. Selective saporin lesions of BF cholinergic neurons did not alter the enhancement of cortical GBO power induced by BF PV stimulation. Importantly, bilateral optogenetic inhibition of BF PV neurons decreased the power of the 40-Hz auditory steady-state response, a read-out of the ability of the cortex to generate GBO used in clinical studies. Our results are surprising and novel in indicating that this presumptively inhibitory BF PV input controls cortical GBO, likely by synchronizing the activity of cortical PV interneurons. BF PV neurons may represent a previously unidentified therapeutic target to treat disorders involving abnormal GBO, such as schizophrenia.

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Section: Discussionsupporting

confidence: 68%

“…Many cortically projecting BF GABAergic neurons contain the calcium-binding protein PV, and a large majority of BF PV neurons are GABAergic (21,22). Recordings from identified BF PV neurons in anesthetized animals revealed they increase their discharge rate during cortical activation induced by sensory stimulation (23). Furthermore,…”

mentioning

confidence: 99%

Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations

Kim

Thankachan

Mckenna

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

267

256

View full text Add to dashboard Cite

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“…1B). Assessments of the electrophysiological characteristics of Cy3-labeled neurons with cell-attached or whole-cell recordings revealed spontaneous or evoked firing activity similar to that reported previously in BFCNs [40][41][42][43]. In acute brain slices, approximately a third of Cy3-positive cells (6/21; 28.5%) revealed slow and irregular firing under cell-attached recording, with the rest electrically silent (15/21; 71.5%) but firing transiently under depolarizing conditions (30 mM extracellular K + ; data not shown).…”

Section: Resultssupporting

confidence: 79%

Low-Affinity Neurotrophin Receptor p75 Promotes the Transduction of Targeted Lentiviral Vectors to Cholinergic Neurons of Rat Basal Forebrain

et al. 2016

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Basal forebrain cholinergic neurons (BFCNs) are one of the most affected neuronal types in Alzheimer's disease (AD), with their extensive loss documented at late stages of the pathology. While discriminatory provision of neuroprotective agents and trophic factors to these cells is thought to be of substantial therapeutic potential, the intricate topography and structure of the forebrain cholinergic system imposes a major challenge. To overcome this, we took advantage of the physiological enrichment of BFCNs with a low-affinity p75 neurotrophin receptor (p75 NTR ) for their targeting by lentiviral vectors within the intact brain of adult rat. Herein, a method is described that affords selective and effective transduction of BFCNs with a green fluorescence protein (GFP) reporter, which combines streptavidinbiotin technology with anti-p75 NTR antibody-coated lentiviral vectors. Specific GFP expression in cholinergic neurons was attained in the medial septum and nuclei of the diagonal band Broca after a single intraventricular administration of such targeted vectors. Bioelectrical activity of GFP-labeled neurons was proven to be unchanged. Thus, proof of principle is obtained for the utility of the lowaffinity p75 NTR for targeted transduction of vectors to BFCNs in vivo.

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“…Throughout the forebrain, Parv ϩ neurons are commonly fast spiking cells, as evident from in vitro and in vivo recording studies of identified neurons (Celio, 1986;Kawaguchi et al, 1987;Kawaguchi, 1993;Kawaguchi and Kubota, 1993;Sik et al, 1995). In the medial septumdiagonal band, Parv ϩ cells have been found to be fast spiking by in vitro recordings (Morris et al, 1999) and in the BF (in one cell) by in vivo recordings (Duque et al, 2000). In our in vivo recording studies, we identified a large number of cortically projecting GAD ϩ neurons that discharge tonically at relatively high rates (average Ͼ 30 Hz) in association with cortical activation (Manns et al, 2000a) and thus could correspond to the cortically projecting, Parv ϩ BF neurons identified here.…”

Section: Functional Significance Of Cbp Content In Bf Cell Groupsmentioning

confidence: 92%

Parvalbumin, calbindin, or calretinin in cortically projecting and GABAergic, cholinergic, or glutamatergic basal forebrain neurons of the rat

Gritti

Manns

Mainville

et al. 2003

J of Comparative Neurology

179

197

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The basal forebrain (BF) plays an important role in modulating cortical activity and facilitating processes of attention, learning, and memory. This role is subserved by cholinergic neurons but also requires the participation of other noncholinergic neurons. Noncholinergic neurons include ␥-amino butyric acidergic (GABAergic) neurons, some of which project in parallel with the cholinergic cells to the cerebral cortex, others of which project caudally or locally. With the original aim of distinguishing different subgroups of GABAergic neurons, we examined immunostaining for the calcium binding proteins (CBPs) parvalbumin (Parv), calbindin (Calb), and calretinin (Calret) in the rat. Although the CBP ϩ cell groups were distributed in a coextensive manner with the GABAergic cells, they were collectively more numerous. Of cells retrogradely labeled with cholera toxin (CT) from the prefrontal or parietal cortex, Parv ϩ and Calb ϩ cells, but not Calret ϩ cells, represented substantial proportions (ϳ35-45% each) that collectively were greater than that of GABAergic projection neurons. From dual immunostaining for the CBPs and glutamic acid decarboxylase (GAD), it appeared that the vast majority (Ͼ90%) of the Parv ϩ group was GAD ϩ , whereas only a small minority (Ͻ10%) of the Calb ϩ or Calret ϩ group was GAD ϩ . Significant proportions of Calb ϩ (Ͼ40%) and Calret ϩ (Ͼ80%) neurons were immunopositive for phosphate-activated glutaminase, the synthetic enzyme for transmitter glutamate. The results suggested that, whereas Calret ϩ cells predominantly comprise caudally or locally projecting, possibly glutamatergic BF neurons, Parv ϩ cells likely comprise the cortically projecting GABAergic BF neurons and Calb ϩ cells the cortically projecting, possibly glutamatergic BF neurons that would collectively participate with the cholinergic cells in the modulation of cortical activity.

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EEG Correlation of the Discharge Properties of Identified Neurons in the Basal Forebrain

Cited by 163 publications

References 47 publications

Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations

Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations

Low-Affinity Neurotrophin Receptor p75 Promotes the Transduction of Targeted Lentiviral Vectors to Cholinergic Neurons of Rat Basal Forebrain

Parvalbumin, calbindin, or calretinin in cortically projecting and GABAergic, cholinergic, or glutamatergic basal forebrain neurons of the rat

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