EEG/ERP as a pragmatic method to expand the reach of infant-toddler neuroimaging in HBCD: Promises and challenges

Norton, Elizabeth S.; MacNeill, Leigha A.; Harriott, Emily M.; Allen, Norrina B; Krogh-Jespersen, Sheila; Smyser, Christopher D.; Rogers, Cynthia; Smyser, Tara A.; Luby, Joan L.; Wakschlag, Lauren S.

doi:10.1016/j.dcn.2021.100988

Cited by 31 publications

(27 citation statements)

References 140 publications

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“…EEGs were collected during a task-free video baseline for each age group over the course of approximately 5 min. Although a silent video played to promote wakefulness, these data are considered resting state EEGs and are in line with the current literature [ 24 ]. EEGs were preprocessed in Matlab using the standard Harvard Automated Processing Pipeline for Electroencephalography (HAPPE) [ 37 ], in which data were band-pass filtered (0.5–45 Hz), bad channels were rejected, and artifacts were removed via wavelet-enhanced thresholding and ICA with automated component rejection.…”

Section: Methodssupporting

confidence: 62%

“…The brain is a complex system of rhythmic activity, and these rhythms or oscillations modulate mental experience and determine how the brain processes environmental input [ 20 ]. These rhythms develop in infancy and have been used to better understand the emergence of learning [ 21 , 22 ], language processing [ 23 ], and the general development [ 24 ] of neural networks in infants. EEG is a direct measure of this neuronal activity—representative of the population firing of neuronal ensembles—and is reflective of underlying cognitive processes.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Early Nutrition Factors on Baseline Neurodevelopment during the First 6 Months of Life: An EEG Study

et al. 2023

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Throughout infancy, the brain undergoes rapid changes in structure and function that are sensitive to environmental influences, such as diet. Breastfed (BF) infants score higher on cognitive tests throughout infancy and into adolescence than formula fed (FF) infants, and these differences in neurocognitive development are reflected in higher concentrations of white and grey matter as measured by MRI. To further explore the effect diet has on cognitive development, electroencephalography (EEG) is used as a direct measure of neuronal activity and to assess specific frequency bands associated with cognitive processes. Task-free baseline EEGs were collected from infants fed with human milk (BF), dairy-based formula (MF), or soy-based formula (SF) at 2, 3, 4, 5, and 6 months of age to explore differences in frequency bands in both sensor and source space. Significant global differences in sensor space were seen in beta and gamma bands between BF and SF groups at ages 2 and 6 months, and these differences were further observed through volumetric modeling in source space. We conclude that BF infants exhibit earlier brain maturation reflected in greater power spectral density in these frequency bands.

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Section: Methodssupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Effects of Early Nutrition Factors on Baseline Neurodevelopment during the First 6 Months of Life: An EEG Study

et al. 2023

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“…Indeed, the EEG is actually used in several clinical settings with diagnostic and prognostic purposes [ 15 , 16 ]. In the research field, it is commonly used to link a modulation in its signal during a task execution (ERP, event related potential) to a specific cognitive process [ 17 , 18 ]. Further, it is possible to investigate the cognitive functions through the analysis of the brain’s oscillatory activity.…”

Section: Introductionmentioning

confidence: 99%

The Role of Alpha Oscillations among the Main Neuropsychiatric Disorders in the Adult and Developing Human Brain: Evidence from the Last 10 Years of Research

et al. 2022

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Alpha oscillations (7–13 Hz) are the dominant rhythm in both the resting and active brain. Accordingly, translational research has provided evidence for the involvement of aberrant alpha activity in the onset of symptomatological features underlying syndromes such as autism, schizophrenia, major depression, and Attention Deficit and Hyperactivity Disorder (ADHD). However, findings on the matter are difficult to reconcile due to the variety of paradigms, analyses, and clinical phenotypes at play, not to mention recent technical and methodological advances in this domain. Herein, we seek to address this issue by reviewing the literature gathered on this topic over the last ten years. For each neuropsychiatric disorder, a dedicated section will be provided, containing a concise account of the current models proposing characteristic alterations of alpha rhythms as a core mechanism to trigger the associated symptomatology, as well as a summary of the most relevant studies and scientific contributions issued throughout the last decade. We conclude with some advice and recommendations that might improve future inquiries within this field.

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“…There has been a proliferation of multi-site studies aimed at collecting big datasets to examine patterns of brain-behavior development in diverse populations 14,17 . The ongoing Adolescent Brain and Cognitive Development (ABCD) 14 and the Healthy Brain and Child Development (HBCD) studies are prototypical examples 17,30 . The ABCD study is a collaborative, multi-site research endeavor aimed at investigating multiple biological and environmental influences on typically developing children's neurocognitive and brain function 14 .…”

Section: Overview Of Large-scale Neurodevelopment Studies: Challenges...mentioning

confidence: 99%

“…14 Unlike ABCD which involves adolescents, the HBCD study is similar in size, but designed to track brain development and physical and mental health beginning in utero until age 10 years. 30 This longitudinal study will use a variety of data collection tools to investigate the role of adverse environments and socioeconomic disadvantage on brain development. 30 Both the ABCD and HBCD studies are well-designed projects with large sample sizes (nearly 12000 children for ABCD and 9000 for HBCD) and might potentially generate more reproducible and generalizable findings.…”

Section: Overview Of Large-scale Neurodevelopment Studies: Challenges...mentioning

confidence: 99%

The Global Brain Consortium’s GLAD White Paper: Challenges and Prospects for a Multi-National Children and Adolescents’ Brain Health Study

Bonney¹,

Byington²,

Miranda-Domínguez³

et al. 2023

Preprint

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Developmental brain health is paramount to the future of all society. As such, many western countries have heavily invested in several large-scale studies of brain development including the Adolescent Brain Cognitive Development (ABCD) study, and the Healthy Brain and Child Development (HBCD) study. However, since brain development and brain determinants of health are multidimensional and variable, true advancement requires a broader sampling of our populations – a global effort beyond western countries. To this end, advancing global brain health science requires a large effort in developing measures and testing protocols, methodological approaches, theoretical perspectives and systems that have cross-cultural relevance, and can be employed to generate globally representative data to inform inclusive public health interventions. In this White Paper, we discuss the daunting challenges of population neuroscience with specific focus on children and adolescents. After an executive summary and a concise overview of the major issues yet to be resolved, we present the global longitudinal study on child and adolescent development (GLAD) initiative and explain how it could potentially be deployed to generate globally relevant data to optimize brain health in young people across diverse contexts. Throughout the document, we emphasize that to optimize children’s brain health, we need to foster strong collaboration among multiple stakeholders including researchers, clinicians, educators, policy experts, and funding organizations.

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EEG/ERP as a pragmatic method to expand the reach of infant-toddler neuroimaging in HBCD: Promises and challenges

Cited by 31 publications

References 140 publications

Effects of Early Nutrition Factors on Baseline Neurodevelopment during the First 6 Months of Life: An EEG Study

Effects of Early Nutrition Factors on Baseline Neurodevelopment during the First 6 Months of Life: An EEG Study

The Role of Alpha Oscillations among the Main Neuropsychiatric Disorders in the Adult and Developing Human Brain: Evidence from the Last 10 Years of Research

The Global Brain Consortium’s GLAD White Paper: Challenges and Prospects for a Multi-National Children and Adolescents’ Brain Health Study

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