EEG-fMRI

Moeller, Friederike; Tyvaert, Louise; Nguyen, Dang Khoa; LeVan, Pierre; Bouthillier, Alain; Kobayashi, Eliane; Tampieri, Donatella; Dubeau, François; Gotman, Jean

doi:10.1212/wnl.0b013e3181c55d17

Cited by 106 publications

(117 citation statements)

References 26 publications

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“…Combined EEG‐fMRI usually markedly improves the fMRI mapping of the epileptic activity (Moeller et al., 2009), with the requirement of the activity to be present during the multimodal scanning. However, our patients did not exhibit epileptic activity.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the pulsation abnormalities could be linked to the detected abnormalities in neurovascular coupling in epilepsy, where an abnormal and prolonged dilation in the blood vessels are detected prior to epileptiform activity (Jacobs et al., 2009; Mäkiranta et al., 2005; Moeller et al., 2009; Osharina, Aarabi, Manoochehri, Mahmoudzadeh, & Wallois, 2017). Prolonged vasodilatations may minimize glymphatic pulsation of the perivascular CSF reservoir and lead to altered tissue homeostasis and further to epileptic activity (Jessen et al., 2015).…”

Section: Discussionmentioning

confidence: 99%

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Altered physiological brain variation in drug‐resistant epilepsy

et al. 2018

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IntroductionFunctional magnetic resonance imaging (fMRI) combined with simultaneous electroencephalography (EEG‐fMRI) has become a major tool in mapping epilepsy sources. In the absence of detectable epileptiform activity, the resting state fMRI may still detect changes in the blood oxygen level‐dependent signal, suggesting intrinsic alterations in the underlying brain physiology.MethodsIn this study, we used coefficient of variation (CV) of critically sampled 10 Hz ultra‐fast fMRI (magnetoencephalography, MREG) signal to compare physiological variance between healthy controls (n = 10) and patients (n = 10) with drug‐resistant epilepsy (DRE).ResultsWe showed highly significant voxel‐level (p < 0.01, TFCE‐corrected) increase in the physiological variance in DRE patients. At individual level, the elevations range over three standard deviations (σ) above the control mean (μ) CVMREG values solely in DRE patients, enabling patient‐specific mapping of elevated physiological variance. The most apparent differences in group‐level analysis are found on white matter, brainstem, and cerebellum. Respiratory (0.12–0.4 Hz) and very‐low‐frequency (VLF = 0.009–0.1 Hz) signal variances were most affected.ConclusionsThe CVMREG increase was not explained by head motion or physiological cardiorespiratory activity, that is, it seems to be linked to intrinsic physiological pulsations. We suggest that intrinsic brain pulsations play a role in DRE and that critically sampled fMRI may provide a powerful tool for their identification.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Altered physiological brain variation in drug‐resistant epilepsy

et al. 2018

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“…EEG/fMRI may help in the evaluation of patients who are candidates for surgery 6 and, in patients with nonlesional frontal lobe epilepsy, EEG/fMRI contributed to localize foci subsequently confirmed by other imaging modalities or pathology. 7 Finally, in a postsurgical population, it was shown that when the resection included the BOLD activation region, patients showed good outcome.…”

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confidence: 99%

Contribution of EEG/fMRI to the definition of the epileptic focus

Pittau

Dubeau²,

Gotman³

2012

Neurology

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Objectives:To evaluate the clinical relevance of EEG/fMRI in patients with focal epilepsy, by assessing the information it adds to the scalp EEG in the definition of the epileptic focus. Methods:Forty-three patients with focal epilepsy were studied with EEG/fMRI using a 3-T scanner. Blood oxygen levelϪdependent (BOLD) signal changes related to interictal epileptic discharges (IEDs) were classified as concordant or not concordant with the scalp EEG spike field and as contributory if the BOLD signal provided additional information to the scalp EEG about the epileptic focus or not contributory if it did not. We considered patients having intracerebral EEG or a focal lesion on MRI as having independent validation.Results: Thirty-three patients had at least 3 IEDs during the EEG/fMRI acquisition (active EEG), and all had a BOLD response. In 29 of 33 (88%) patients, the BOLD response was concordant, and in 21 of 33 (64%) patients, the BOLD response was contributory. Fourteen patients had an independent validation: in 12 of these 14, the BOLD responses were validated and in 2 they were invalidated. Conclusions:A BOLD response was present in all patients with active EEG, and more specific localization of the epileptic focus was gained from EEG/fMRI in half of the patients who were scanned, when compared with scalp EEG alone. This study demonstrates that EEG/fMRI, in the context of a clinical practice, may contribute to the localization of the interictal epileptic generator in patients with focal epilepsy. Neurology ® 2012;78:1479-1487 GLOSSARY BOLD ϭ blood oxygen levelϪdependent; EPI ϭ echoplanar imaging; FCD ϭ focal cortical dysplasia; IED ϭ interictal epileptic discharge; MTS ϭ mesial temporal lobe sclerosis; SEEG ϭ stereo-EEG; TE ϭ echo time; TR ϭ repetition time.Recording fMRI and EEG simultaneously is a noninvasive method detecting cerebral hemodynamic changes related to interictal epileptic discharges (IEDs) on scalp EEG. Several studies demonstrated the ability of EEG/fMRI to characterize various forms of focal and generalized epilepsy.1,2 In patients with focal epilepsy, especially those who are pharmacoresistant and surgical candidates, the significant clinical question is how the blood oxygenation levelϪde-pendent (BOLD) changes related to IEDs can contribute to localize the epileptic focus. The BOLD signal usually increases in regions generating focal IEDs, 3 but often in the context of more widespread, or even distant, responses.4 Simultaneous intracranial EEG/fMRI recordings 5 have shown IED-related BOLD changes in the immediate vicinity of the intracranial EEG focus, confirming spatial concordance between neuronal and BOLD changes. Distant BOLD changes related to specific IED patterns were also observed. EEG/fMRI may help in the evaluation of patients who are candidates for surgery 6 and, in patients with nonlesional frontal lobe epilepsy, EEG/fMRI contributed to localize foci subsequently confirmed by other imaging modalities or pathology.7 Finally, in a postsurgical population, it was shown that...

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“…It is now possible to delineate structural and functional information of the part of the brain that causes seizures in patients with epilepsy disorder by combining EEG, MRI, and fMRI findings [11,19,20]. They can help to better localize the focus [21][22][23][24]. Hence, we decided to integrate EEG recordings, MRI, and fMRI in the proposed system as multimodal imaging parameters.…”

Section: The Content Of Multimodalitymentioning

confidence: 99%

Multimodal medical imaging repository and information system in epilepsy surgery

Akdeniz¹,

Atlı²,

Çelebi³

2018

Turk J Elec Eng & Comp Sci

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Surgery is an option for patients with drug-resistant epilepsy, but it requires a comprehensive assessment.Electroencephalography (EEG), magnetic resonance imaging (MRI), and functional MRI (fMRI) are used to localize the epileptogenic zone, which directly affects the surgery outcome. Accessing EEG, MRI, and fMRI results and patient information simultaneously using traditional methods might result in misinformation and increase the workload of clinicians. In this study, we developed a modern web-based repository system for the preoperative evaluation of epilepsy disorder, including multimodal medical images and patient information. Our dedicated system is enriched with clinical metadata that are not currently available and is managed with an online application. It overcomes the identified problem and minimizes possible medical errors. In conclusion, this system has the potential to accelerate surgical procedures, get reliable results, and improve the seizure outcome. It is an extensive solution for epilepsy hospitals and clinical research centers. It may serve as a standard template for archiving multiple imaging techniques.

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EEG-fMRI

Cited by 106 publications

References 26 publications

Altered physiological brain variation in drug‐resistant epilepsy

Altered physiological brain variation in drug‐resistant epilepsy

Contribution of EEG/fMRI to the definition of the epileptic focus

Multimodal medical imaging repository and information system in epilepsy surgery

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