Efectos de la administración de (RS)-3,4-DCPG, un antagonista mixto de los receptores AMPA y agonista de los receptores mGlu8, en la conducta agresiva de los ratones

Navarro, José Francisco; Castro, Vanessa De; Martı́n-López, Mercedes

doi:10.1016/s1888-9891(09)72404-8

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Studies to date suggest that mGluR8 might not regulate aggressive behavior. As such, mGluR8 agonist ( S )-3,4-Dicarboxyphenylglycine ((S)-3,4-DCPG) and the combined mGluR8 agonist and AMPA receptor antagonist ( RS )-3,4-Dicarboxyphenylglycine ((RS)-3,4-DCPG) did not affect aggressive behavior or social investigation in the standard opponent test [132,133]. However, additional experiments using other selective ligands for mGluR8 are needed to confirm these results.…”

Section: Role Of Mglurs In Male Aggressive Behaviormentioning

confidence: 99%

The Role of Metabotropic Glutamate Receptors in Social Behavior in Rodents

Zoicas

Kornhuber

2019

IJMS

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The appropriate display of social behavior is critical for the well-being and survival of an individual. In many psychiatric disorders, including social anxiety disorder, autism spectrum disorders, depression and schizophrenia social behavior is severely impaired. Selective targeting of metabotropic glutamate receptors (mGluRs) has emerged as a novel treatment strategy for these disorders. In this review, we describe some of the behavioral paradigms used to assess different types of social behavior, such as social interaction, social memory, aggressive behavior and sexual behavior. We then focus on the effects of pharmacological modulation of mGluR1-8 on these types of social behavior. Indeed, accumulating evidence indicates beneficial effects of selective ligands of specific mGluRs in ameliorating innate or pharmacologically-induced deficits in social interaction and social memory as well as in reducing aggression in rodents. We emphasize the importance of future studies investigating the role of selective mGluR ligands on different types of social behavior to provide a better understanding of the neural mechanisms involved which, in turn, might promote the development of selective mGluR-targeted tools for the improved treatment of psychiatric disorders associated with social deficits.

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Section: Role Of Mglurs In Male Aggressive Behaviormentioning

confidence: 99%