Efeito De Aloe Vera Linné Sobre a Cicatrização De Feridas De Pele Em Coelhos

Dorneles, Daniela; Wouk, Antônio Felipe Paulino de Figueiredo; Pontarolo, Roberto; Oliveira, Andrezza Beatriz

doi:10.5380/acd.v4i1.521

Cited by 7 publications

(7 citation statements)

References 2 publications

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“…This infers that the crude extract of Euphorbia tirucalli has stimulatory properties on the collagen secretion without promoting, however, the migratory or replicator activity of fibroblasts. These positive results with regard to healing have also been observed in other studies with plants of the tropics, such as mastic, calendula, babassu, mastruz and pião-roxo 8,9,23,25 .…”

Section: Discussionsupporting

confidence: 79%

Evaluation of the use of raw extract of Euphorbia tirucalli L. in the healing process of skin wounds in mice

Filho

Santos²,

Barros³

et al. 2013

Acta Cir. Bras.

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PURPOSE:To evaluate the effects of crude extract of Euphorbia tirucalli in cutaneous wound healing. METHODS:A total of 20 Swiss mice were randomly divided into two groups, aveloz (GA) and control (CG), and each group was further divided into two subgroups based on the deaths scheduled for the 7th and 14th days after surgery. The animals underwent a resection of cutaneous fragment with 1cm in diameter on the dorsum; the GA was applied in each animal on the subsequent days, 0.1 mL (30 mg/mL) hydroalcoholic extract of Euphorbia tirucalli was applied on the wound, while the same volume of 0.9% saline solution was applied to the GC. It was evaluated the lesion diameter and after programmed death, a surgical specimen was resected for histopathology. RESULTS:In the macroscopic analysis, no statistically significant difference was observed (p = 0.120 and p = 0.186, for the 7th and 14th days of death, respectively). The histological evaluation revealed no statistically significant difference in the variables acute inflammation (p = 0.014) and fibrosis (p = 0.018), when compared the group aveloz with the control group on day 14. CONCLUSION:The crude hydroalcoholic extract of Euphorbia tirucalli L. demonstrated better outcomes in the healing process, acute inflammation and fibrosis on the 14 day postoperatively.

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Section: Discussionsupporting

confidence: 79%

Evaluation of the use of raw extract of Euphorbia tirucalli L. in the healing process of skin wounds in mice

Filho

Santos²,

Barros³

et al. 2013

Acta Cir. Bras.

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“…Several plants are used in popular medicine for the treatment of skin disorders. A number of these, such as Aloe vera (“babosa”), Schinus terebenthifolius (“aroeira”), Stryphnodendrom barbatiman (“barbatimão”), Calendula officinalis (“calendula”) and Triticum vulgare (“trigo”) are especially worthy of note due to the number of Brazilian studies involving the phytopharmaceutical use of these species [ 71 – 74 ].…”

Section: Discussionmentioning

confidence: 99%

Leishmanicidal, cytotoxicity and wound healing potential of Arrabidaea chica Verlot

Sá

Almeida-Souza

Mondêgo-Oliveira

et al. 2015

BMC Complement Altern Med

150

194

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BackgroundLeishmaniasis includes a wide complex of diseases that affect humans and other mammals, and can range from a mild cutaneous form to a severe visceral type. The safety of the standard treatment using pentavalent antimony is a concern due to its toxic effects. The search for alternative, effective and less toxic treatments has led to the testing of natural products. The present study aimed to evaluate the cytotoxic, leishmanicidal and healing potential of Arrabidaea chica.MethodsThe crude ethanolic extract, as well as the chloroform, methanol and ethyl acetate fractions of A. chica were prepared and phytochemical analysis was performed. Cytotoxic evaluation was carried out through MTT colorimetric assay, and the 50 % cellular cytotoxicity was determined. After that, the effect of the extract and fractions against Leishmania amazonensis promastigotes, at intervals of 24, 48 and 72 h, was analyzed, and 50 % inhibitory concentration was determined. The healing effect of the plant was also tested in surgical lesions in Swiss mice skin.ResultsPhytochemical screening showed that the crude extracts contained flavonoids, tannins, anthocyanidins and chalcones. The leishmanicidal potential of A. chica produced satisfactory results in concentrations of between 60 and 155.9 μg/mL. Cytotoxic assay revealed a 50 % reduction in viable cells at a concentration of 189.9 μg/mL. The healing results indicated that the treated group exhibited more pronounced signs of lesion resolution in the early period, but this pattern did not persist throughout the treatment.ConclusionsThe results of the present study demonstrate that A. chica has cytotoxic and leishmanicidal potential but its healing effect must be better studied.

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“…The first fraction is a yellow-red fluid extracted from cells of the pericycle which is rich in anthracene compounds. The second transparent gel-like portion (mucilage) originates from the leaf parenchyma and has been used for the treatment of burns and wounds because of its healing properties 9 . This mucilage consists of biologically active molecules that act on fibroblasts during the formation of cicatricial tissue, stimulating the deposition of collagen fibers in the extracellular matrix 10 .…”

Section: Introductionmentioning

confidence: 99%

Effects of the application of Aloe vera (L.) and microcurrent on the healing of wounds surgically induced in Wistar rats

et al. 2009

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PURPOSE: To investigate the effects of topical application of an Aloe vera gel combined or not with microcurrent application on the healing of skin wounds surgically induced in Wistar rats. METHODS: The animals were randomly divided into the following groups: control group, animals topically treated with Aloe vera, animals treated with a microcurrent, and animals receiving topical application of Aloe vera combined with microcurrent application. RESULTS: The results indicated differences in wound healing between the various treatments when compared to the control group. Tissue hyperplasia was lower in the control group compared to the other treated groups. Accelerated wound healing was observed in the group treated with Aloe vera compared to control. Animals submitted to microcurrent application only and the group treated with microcurrent plus Aloe vera presented an earlier onset of the proliferative phase compared to the control group and animals treated with Aloe vera gel alone. Morphometric data confirmed the structural findings. CONCLUSION: Simultaneous application of Aloe vera gel and microcurrent is an excellent choice for the treatment of open wounds thus indicating a synergistic action of these two applications.

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Efeito De Aloe Vera Linné Sobre a Cicatrização De Feridas De Pele Em Coelhos

Cited by 7 publications

References 2 publications

Evaluation of the use of raw extract of Euphorbia tirucalli L. in the healing process of skin wounds in mice

Evaluation of the use of raw extract of Euphorbia tirucalli L. in the healing process of skin wounds in mice

Leishmanicidal, cytotoxicity and wound healing potential of Arrabidaea chica Verlot

Effects of the application of Aloe vera (L.) and microcurrent on the healing of wounds surgically induced in Wistar rats

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