Efeitos da aplicação do L.A.S.E.R. HeNe e do ultravioleta B no vitiligo

Vitiligo is chronic idiopathic disorder of skin pigmentation that plays havocs with the social livings of patients. Its major symptom is the occurrence of white patches/lesions on human skin. It affects 1-2 % of general population. A 15 years juvenile patient was affected by generalized Vitiligo with no familial history of the ailment. The patient was asked to take two table spoonful of honey per oral mixed with one cup of boiled milk of cow early in the morning daily. White de-pigmented skin was observed to be partially re-pigmented after 4 months with the reversal of disease progression.

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Interventions for vitiligo

Whitton

Pinart

Batchelor

et al. 2015

Cochrane Database of Systematic Reviews

124

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Revisão de terapias no aumento de resposta da atividade melanocítica para repigmentação cutânea de portadores com vitiligo

Ventura

Miranda

Costa

et al. 2021

RSD

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O vitiligo é uma doença imunológica caracterizada pela despigmentação da pele, causando manchas acrômicas, sem predileção por sexo ou etnia. Ademais, pode provocar alterações emocionais, comprometimento da autoestima e nas relações sociais do indivíduo. Assim, esse trabalho propõe uma revisão sistemática da literatura objetivando evidenciar a eficiência de protocolos de terapias disponíveis para o vitiligo e sua correlação. Metodologia: Trata-se de um estudo de revisão sistemática, de caráter descritivo, retrospectivo realizado a partir de pesquisas nas principais bases de dados acadêmicas. Ex. PubMed, Lilacs e Periódicos Capes, etc. Assim, fez-se buscas livres de palavras relacionadas ao tema proposto: tratamento do vitiligo e associações, excluindo os trabalhos que mostraram ineficiência (baixo percentual de repigmentação) quando comparada aos tratamentos convencionais. Nesse sentido, foram encontrados 35 artigos científicos e 27 terapias distintas para o tratamento de vitiligo. Resultados e Discussão: Tais terapias foram divididas em 4 categorias: corticosteroides, fotobiomodulação, imunossupressores e antioxidantes. O uso de corticosteroides mostrou-se eficaz na estabilização da doença. Das fototerapias, a kelina agiu em 70% dos casos de repigmentação. Já os imunossupressores JAK demonstram repigmentação total ou acima de 75%. E os antioxidantes mostraram eficácia de 67% de repigmentação, com destaque para a espécie Polypodium leucotomos e Brosimum gaudichaudii com alto índice de repigmentação completa, principalmente quando associado a radiação UVB. Já o tratamento com Ginko biloba teve 80% de estabilização da doença. Conclusão: Os protocolos mostraram que a associação das fototerapias com terapias convencionais e inovadoras são mais frequentemente eficazes no tratamento do vitiligo, potencializando os resultados.

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Red-light photons on skin cells and the mechanism of photobiomodulation

Herrera,

Ribas,

da Costa

et al. 2024

Front. Photonics

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Red light (600–700 nm, ∼2.1–1.8 eV) consists of a low-energy radiation with a high capacity to penetrate the skin and to induce stimulatory effects. These characteristics make this wavelength range very promising for light-based therapies. Aiming to discuss the mechanisms of action of photobiomodulation, we start by providing a broad perspective of the skin and of its interaction with light, focusing on the endogenous photosensitizers, on the formation of excited states and reactive oxidants, and on the activation of signaling effectors. The peculiar aspect of the photons in the red spectral range is that they are much less absorbed by the endogenous photosensitizers and consequently generate a lot fewer reactive oxidants (when compared with the other ranges of visible light), allowing the skin to mainly experience the consequences of several signaling pathways that are activated during the skin interaction with red-light photons. Indeed, the effects of red light in epithelial cells involve the control of metabolic responses, the modulation of several key genes and transcriptions factors, as well as the regulation of the intracellular nitric oxide stocks. In this article, we discuss how red light interacts with all these variables and end up causing a vigorous tissue activation. We also analyzed the effect of red-light photons on the nitric oxide homeostasis, with implications for the phototherapy of psoriasis. It is likely that several of the observations and mechanisms described for the interactions of red-light photons may also be occurring during and after the interaction with other photons with similar energy.

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Efeitos da aplicação do L.A.S.E.R. HeNe e do ultravioleta B no vitiligo

Cited by 3 publications

References 30 publications

Interventions for vitiligo

Interventions for vitiligo

Revisão de terapias no aumento de resposta da atividade melanocítica para repigmentação cutânea de portadores com vitiligo

Red-light photons on skin cells and the mechanism of photobiomodulation

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