EFEK ANTIDIARE EKSTRAK ETANOL DAUN MINDI (Melia azedarach Linn) PADA MENCIT SWISS WEBSTER JANTAN

Suherman, Linda P; Hermanto, Faizal; Pramukti, Mochammad Luthfi

doi:10.26874/kjif.v1i1.24

Cited by 5 publications

(4 citation statements)

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“…Feces consistency is determined by scoring the feces; namely, a score of 1 for normal feces, score 2 for slightly soft feces, score 3 for very soft feces, and score 4 for soft liquid feces. The smaller the feces consistency value, the greater the anti-diarrhea effect produced [23]. The positive control group showed that the consistency of the stool changed back to the normal stool at 64 h. The extract ethanol melinjo leaves also had an effect on changing the consistency of feces to normal or healing diarrhea in rats.…”

Section: Feces Consistencymentioning

confidence: 92%

Antidiarrheal Activity of Extract Ethanol Melinjo Leaves (Gnetum Gnemon L. (Linn.)) in Wistar Male White Rats Induced by Escherichia Coli and Extract Standardization

Herlina

SOLIHAH²,

WIJAYA³

et al. 2022

Int J App Pharm

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Objective: Determination of the antidiarrheal activity of extract ethanol melinjo leaves (Gnetum gnemon L. (Linn.)) in Wistar male white rats induced by Escherichia coli and extract standardization has been performed. Methods: This research was conducted by in vivo method using white male rats of Wistar strain induced by Escherichia coli. The treatment group was divided into 6 groups: normal, negative control, positive control, and groups with doses 150, 300, and 600 mg/kg BW. Negative control was given Na-CMC and positive control Gentamicin. The initial time diarrhea occurred 24-30 h after administration of Escherichia coli suspension. Results: The results of the phytochemical screening of the ethanolic extract of melinjo contain secondary metabolites of flavonoids, steroids, tannins, and saponins. Standardization of the extract ethanol melinjo leaves (Gnetum gnemon L.) meet the predetermined standards, while the acid insoluble ash content parameters did not meet the predetermined standards. The parameters feces weight, feces consistency, frequency diarrhea, body weight, number of Escherichia coli colonies feces dose 600 mg/kg BW had an effect that was almost close to positive control. The results showed that anti-diarrheal effect dose 150 mg/kg BW 35.75%, dose 300 mg/kg BW 43.02%, dose 600 mg/kg BW 50.14%. This shows that ethanol extract melinjo leaves dose 600 mg/kg BW wasn’t significantly different from the positive control (p<0.05). Effective Dose (ED50) Ethanol Extract Melinjo Leave as antidiarrheal was 578.2468 mg/kg BW. Conclusion: Extract ethanol melinjo leaves (Gnetum gnemon L. (Linn)) dose 600 mg/kg BW has the potential to be used as antidiarrheal and its extract meet the predetermined standards, except the acid insoluble ash content parameters did not meet the predetermined standards.

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Section: Feces Consistencymentioning

confidence: 92%

Antidiarrheal Activity of Extract Ethanol Melinjo Leaves (Gnetum Gnemon L. (Linn.)) in Wistar Male White Rats Induced by Escherichia Coli and Extract Standardization

Herlina

SOLIHAH²,

WIJAYA³

et al. 2022

Int J App Pharm

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“…The content of tannin and flavonoid compounds in extracts of red shoots of Syzygium myrtifolium Walp are suspected to have antidiareal activity. Tanin acts as an antidiarrheal which works as an adstringentia mechanism, able to shrink the mucous membrane of the intestine and strengthen the intestinal wall sothe possibility of blocking the absorption of bacteria and toxins while reducing fluid expenditure [11].…”

Section: Antidiarrheal Testmentioning

confidence: 99%

Utilizing of 96% Etanol Extract Activity Red Leaf (Syzygium myrtifolium Walp.) Maseration and Socletation Method as an Antidiarrhea at Male Mice

2019

ijrte

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Diarrhea is still one of the most important public health problems because it is the third major contributor to child morbidity and mortality in Indonesia. One of the traditional medicines that can be used to treat diarrhea is red shoots. Red shoot leaves contain secondary metabolites such as alkaloids, flavonoids, chalcones, tannins, and terpenoids which can be used as antidiarrheals. The purpose of this study was to compare the antidiare effects between extracts of maceration and socletation of red shoot leaves and determine the effective dose of both extracts as antidiarrheal in male mice using the intestinal transit method. The treatment in this study consisted of the administration of ethanol extract of shoots of red shoots by maceration at a dose of 1.58 mg / 20 g BW (dose of MI), 4.75 mg / 20g BW (dose of M.II), 6.33 mg / 20g BB (Dosage M.III) and ethanol extract of shoots of red shoots by socletation at a dose of 1.67 mg / 20 g BB (SI dose), 5.04 mg / 20 g BB (Dosage S.II), 6.72 mg / 20 g BB (Dose S.III), Loperamid HCl as positive control, and 1% CMC suspension as negative control. Observations were made by measuring the ratio of intestinal length traveled through the norit (marker) to the total gut length. The results showed that all dose treatments on maceration and socletation ethanol extracts had antidiareal activity. Different extraction methods give the same effect in giving antidiarrheal effects. Based on Duncan's advanced dose of 6.72 mg / 20 g BW of socletation results is an effective dose as antidiarrheal because it has an effect that is not significantly different than Loperamid HCl.

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“…In determining the consistency of faeces done by looking at the shape that occurs it can be categorized into four groups, namely not chapter (0), normal (1), soft (2), and slimy/watery (3). Consistency seen visually was assessed using Scoring, so that groups that were declared to have antidiarrheal effects were the group that showed the smallest consistency rate (Suherman et al, 2013). group.…”

Section: Stool Consistencymentioning

confidence: 99%

“…group. The smaller the number of stool consistency, the greater the antidiare effect produced (Suherman et al, 2013). The results of the study of ethanol extract of the leaves of V. amygdalina 400 mg/kg BW which have the best effect as antidiarrheal are associated with a corresponding increase in dosage, the effect also increases (Nurhalimah et al, 2015).…”

Section: Stool Consistencymentioning

confidence: 99%

Antidiarrheal Activity of Ethanolic Extract of Vernonia amygdalina Del Leaves againts Male Mice Induced by Oleum Ricini

2019

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Leaves of Vernonia amygdalina Del. is one of the alternative plants that people use as antidiarrheal in Martapura, Banjar. The purpose of research to determine the antidiarrheal activity and the effectiveness of ethanolic extract of leaves against male mice. The negative control was given NaCMC 0.5% orally, positive control was given Loperamide HCl 0.005 mg/20 g orally, and groups of ethanolic extract of leaves were given dosages in 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW orally. After 1 hour of treatment, the groups were induced by Oleum ricini orally and were observed for 4 hours. Based on three parameters were frequency, weight, and consistency of diarrhea. From the results observation of that negative control, positive control, EEDA 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW for diarrhea frequency parameter was 7.4 � 2.30; 2 � 1.22; 5.8 � 3.34; 6.2 � 4.08; 2.4 � 1.67; the weight parameter was 1.34 � 0.43; 0.38 � 0.29;0.66 � 0.56; 0.57 � 0.38; 0.49 � 0.33 and then consistency of diarrhea with EEDA 400 mg/kg BW improved the consistency at 180 minutes compared to control group at 210 minutes. In conclusion, from all parameters of ethanolic extract of Vernonia amygdalina Del. leaves can give an antidiarrhea effect with optimum dosage is 400 mg/kg BW.

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EFEK ANTIDIARE EKSTRAK ETANOL DAUN MINDI (Melia azedarach Linn) PADA MENCIT SWISS WEBSTER JANTAN

Cited by 5 publications

References 0 publications

Antidiarrheal Activity of Extract Ethanol Melinjo Leaves (Gnetum Gnemon L. (Linn.)) in Wistar Male White Rats Induced by Escherichia Coli and Extract Standardization

Antidiarrheal Activity of Extract Ethanol Melinjo Leaves (Gnetum Gnemon L. (Linn.)) in Wistar Male White Rats Induced by Escherichia Coli and Extract Standardization

Utilizing of 96% Etanol Extract Activity Red Leaf (Syzygium myrtifolium Walp.) Maseration and Socletation Method as an Antidiarrhea at Male Mice

Antidiarrheal Activity of Ethanolic Extract of Vernonia amygdalina Del Leaves againts Male Mice Induced by Oleum Ricini

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