EFEK ANTIKOLESTEROL FRAKSI n-HEKSANA RUMPUT KEBAR PADA HEWAN MODEL HIPERLIPIDAEMIA

Sambodo, Priyo; Tethool, Angelina Novita; Rumetor, Sientje Daisy

doi:10.21157/j.ked.hewan.v9i1.2793

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…. Penelitian terakhir menyebutkan bahwa ekstrak rumput kebar dapat menurunkan tingkat kolesterol total pada serum kelinci (Sambodo et al, 2015). Berdasarkan parameter darah, uji toksisitas ekstrak n-hexana rumput kebar pada tikus normal tidak menyebakan ketoksikan dan atau kematian pada hewan coba (Sambodo et al, 2016 (Vaghasiya et al, 2010).…”

Section: Test Of the N-hexane Extract Of Rumput Kebar (Biophytum Peteunclassified

Uji Ekstrak n-Hexana Rumput Kebar (Biophytum petersianum Klotzsch) pada Tikus Wistar Hiperkolesterolemia

Sambodo

Purwaningsih

Baaka

et al. 2019

Jurnal Sain Veteriner

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This study was aimed to determine the secure level of the n-hexane extract of kebar grass on hypercholesterolemia rats based the acute oral toxicity test. Based the literature, no report on the toxic dosage before, initial dose was started at 300 mg/kg body weight (BW) and to be increased 2000 to 5000 mg/kg BW. Toxicity data were set for 24 hours and continued until 14 days after treatment for several parameters, i.e : toxicity symptoms, death of animals, changes in body weight and the manifestation of toxicity effects. At the end of the test, the rats were sacrificed and organs were taken for abnormalities (macroscopy). The results of this study showed that the administration of the n-hexane extract of grass kebar at all doses did not show the toxicity symptoms, mortality and body weight change. The absolute and relative weights and gross pathology observation of the internal organ were normal. Conclusions: the n-hexane extract of grass kebar is safe and the LD was determined on category 5, 50 unclassified or minimum practically non toxic

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Section: Test Of the N-hexane Extract Of Rumput Kebar (Biophytum Peteunclassified

Uji Ekstrak n-Hexana Rumput Kebar (Biophytum petersianum Klotzsch) pada Tikus Wistar Hiperkolesterolemia

Sambodo

Purwaningsih

Baaka

et al. 2019

Jurnal Sain Veteriner

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“…N-hexane fraction of Kebar's grass extract contains saponin that is capable of declining cholesterol level in total blood serum in animal models of hyperlipidemia (Sambodo, Tethool and Rumetor, 2015). Water extract of Kebar's grass can constraint the development of nematode's ova (Baaka, Widayati and Novitanti, 2017).…”

Section: Macroscopic Observation Elevation and Color) Of Bacterialmentioning

confidence: 99%

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2018

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Systematic risk is a risk that cannot be avoided and eliminated by diversification, the fluctuation of this risk is influenced by macroeconomic factors. This study aims to analyze the effect of Degree of Economic Leverage (DEL), Degree of Operating Leverage (DOL), and Degree of Financial Leverage (DFL) on the property and agriculture sector in Indonesia. In this study, researcher used secondary data; those are weekly common stock return and weekly market return published by Indonesia Stock Exchange, for determining beta coefficients. Subsequently, sales, EBIT, EAT, and annual inflation are utilized to calculate DEL, DOL, and DFL. Samples were taken by using purposive sampling and sample selection criteria. This research used panel data regression analysis using E-views 9. The result of this research showed that (1) partially, only the variable DEL and DFL that influence significantly to systematic risks of stock on a property sector and (2) partially, only the variable DEL and DOL that influence significantly to systematic risks of stock on sector of agriculture. Therefore, investors should invest in property sector companies that have a low value of DEL, DOL, and DFL to minimize systematic risk of stocks. And in the agriculture sector companies investors should invest in companies that have a high value of DEL, DOL, and DFL to minimize the systematic risk of stocks. KEY WORDS Systematic risk, economic leverage, operating leverage, financial leverage, property, agriculture.above the DOL variable has a positive effect or is directly s. DOL variable has a probability value of 0.1256 with a coefficient value of 0.00827. These results indicate that every increase in 1 unit of DOL, so that the systematic risk of all issuers in the model will increase by 0.00827 units.coefficient are in accordance with the theory and hypothesis proposed in DOL has a positive effect on the same conditions as the Karuniandari ( 2006), Kartini and Nevsi Rizki Herine Tjun (2009) which showed a positive relationship between DOL and systematic risk on issuers of manufacturing and mining sub-This finding indicates that the DOL value can increase the value of stocks systematic risk in the property sector companies, which is marked by a positive but insignificant DOL Grifin and Dugan (2003). This finding indicates that EBIT changes because sales changes cannot explain systematic ted because a small change in the level of sales does not that can be seen in The increase in the level of sales in property sector companies is not proportional Based on Table 3 above the DFL variable has a positive effect on the real level of 5% r is directly proportional to stocks systematic risk. DFL variable has a probability value of 0.0013 with a coefficient value of 0.00961. These results indicate that for every increase in 1 e model rise by 0.00961 units.

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Nutrient Composition and Secondary Metabolite of Rumput Kebar (Biophytum Petersianum Klotzsch)

Sayuti¹,

Supriatna²,

Hismayasari³

et al. 2018

RJOAS

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Kebar's grass (Biophytum petersianum Klotzsch) was collected from Central and East Kebar region, Manokwari, West Papua, Indonesia in April 2018. The objective of this research was to determine secondary metabolite content in Kebar's grass (B. petersianum, Klotzsch). Kebar's grass sample was cleaned, dried, ground, and analyzed using a procedural standard to get chemical composition, vitamin C content, antioxidant activity, and anti-nutrient content.Based on the research result, the average score of proximate composition for Kebar's grass (B. petersianium Klotzsch) is 5.99% protein, 3.47% fat, 7.81% water, 14.25% ash, 68.47% carbohydrate, 418.20 mg/100g vitamin C, and 0.88 mg/ml antioxidant activity. Kebar's grass (B. petersianium Klotzsch) also contains anti-nutrient compounds/secondary metabolites; flavonoids, tannin, error tannin, phenolic, polyphenol. The test result of TLC-Spectrophotodensitometry shows that Kebar's grass (B. petersianum Klotzsch) contains rutin flavonoid, hyperoside, quercitrin, quercetin, and positively contains phenol and triterpenoid. This research reaches a conclusion that Kebar's grass (B. petersianium Klotzsch) contains essential secondary metabolite compounds for a human.

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EFEK ANTIKOLESTEROL FRAKSI n-HEKSANA RUMPUT KEBAR PADA HEWAN MODEL HIPERLIPIDAEMIA

Cited by 3 publications

References 3 publications

Uji Ekstrak n-Hexana Rumput Kebar (Biophytum petersianum Klotzsch) pada Tikus Wistar Hiperkolesterolemia

Uji Ekstrak n-Hexana Rumput Kebar (Biophytum petersianum Klotzsch) pada Tikus Wistar Hiperkolesterolemia

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Nutrient Composition and Secondary Metabolite of Rumput Kebar (Biophytum Petersianum Klotzsch)

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