Efek ekstrak daun sirsak (Annona muricata Linn) terhadap profil lipid tikus putih jantan (Rattus Norvegicus)

Wurdianing, Indrawati; Nugraheni, SA; Rahfiludin, Zen

doi:10.14710/jgi.3.1.96-101

Cited by 11 publications

(17 citation statements)

References 12 publications

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“…Soursop fruit contains tannins, 14 which play a role in the reduction of triglycerides. 15 Soursop fruit also contains flavonoids, 13 which can inhibit the activity of the HMG-CoA reductase enzyme in the cholesterol synthesis process. The inhibition of this enzyme activity results in the absence of mevalonate from HMG-CoA; mevalonate will be converted to squalene, lanosterol, dihydrolanosterol, D 8-dimethylsterol, 7-dihydrocholesterol, and eventually cholesterol.…”

Section: Discussionmentioning

confidence: 99%

“…Tannins, riboflavin, and cyanide acid have a hypoglycemic effect that can lower cholesterol and triglyceride blood levels in mice. 15,18 Flavonoids in soursop leaves and fruit are antioxidants that have the ability to reduce fat emulsion and cholesterol synthesis. Decreasing fat emulsions and cholesterol synthesis will lower the levels in the blood.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Soursop fruit contains tannins, 14 which play a role in the reduction of triglycerides. 15 Soursop fruit also contains flavonoids, 13 which can inhibit the activity of the HMG-CoA reductase enzyme in the cholesterol synthesis process. This is the necessary for in-depth research (randomized controlled trials, or RCTs) to determine the effect of soursop fruit supplementation compared to control serum potassium levels and cardiovascular risk.…”

Section: Introductionmentioning

confidence: 99%

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Soursop fruit ( Annona muricata Linn.) consumption does not increase serum potassium levels and not significant in cardiovascular risk improvements of prehypertension subjects

Alatas¹,

Sja’bani²,

Irijanto³

et al. 2018

JMedScie

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Patients with chronic kidney disease (CKD) tend to have hyperkalemia. They worry about the consumption of fruit for fear of increased serum potassium levels and therefore require a restricted potassium diet. Soursop fruit (Annona muricata Linn.) is believed to be beneficial for CKD and cardiovascular risk. This study was conducted to investigate the effect of soursop fruit supplement consumption on serum potassium levels and cardiovascular risk in prehypertension subjects from Mlati, Sleman District, Yogyakarta Special Region, Indonesia. A total 143 samples that met to the inclusion and exclusion criteria were subsequently randomized into two groups. Group I was given 2 x 100 g/day of soursop and Group II was without soursop. A laboratory examination from both groups was conducted including potassium, total cholesterol, low density lipoprotein (LDL), high density lipoprotein(HDL), and triglyceride levels at weeks 0; 7; and 13. Regular soursop consumption was evaluated every 2 weeks for 3 months. Data analysis was performed using an independent t test, a nonparametric Mann-Whitney test, and a chi-square test. No significantly different in serum potassium levels between the soursop and non-soursop groups at week 7 and 13 (p=0.073 and p=0.108) was observed. Furthermore, no significantly different in total cholesterol (p=0.254 and p=0.932), LDL (p=0.221 and p=0.710), HDL (p=0.400 and p=0.960), triglycerides (p=0.423 and p=0.580) of both groups was also obsereved. However, in subjects with hypercholesterolemia and hypertriglyceridemia, the mean cholesterol and triglyceride levels decreased compared to no soursop consumption at week 7 and 13. In conclusion, consumption of a soursop fruit supplement of 2 x 100 g/ day for 13 weeks does not affect the serum potassium levels of prehypertension subjects. Moreover, the consumption of a soursop fruit supplement is not significantly different compared to those without soursoup in improving cardiovascular risk. ABSTRAK Pasien penyakit ginjal kronik cenderung mengalami hiperkalemia. Mereka khawatir konsumsi buah karena takut kalium darahnya naik, oleh karena itu perlu restriksi diet kalium. Buah sirsak (Annona muricata Linn.) diduga bermanfaat untuk penyakit ginjal kronik dan risiko kardiovaskular. Penelitian ini dilakukan untuk mengkaji pengaruh pemberian minuman suplemen buah sirsak terhadap kadar kalium darah dan risiko kardiovaskular pada subjek prehipertensi dari Mlati, Sleman, Daerah Istimewa Yogyakarta. Total 143

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Soursop fruit ( Annona muricata Linn.) consumption does not increase serum potassium levels and not significant in cardiovascular risk improvements of prehypertension subjects

Alatas¹,

Sja’bani²,

Irijanto³

et al. 2018

JMedScie

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“…Di Malaysia, daun tumbuhan ini telah digunakan untuk menurunkan tekanan darah, diare dan adstringen. 6 Beberapa kajian ilmiah telah membuktikan bahwa ekstrak dari daun tumbuhan sirsak dapat menghasilkan efek hipoglikemik, 7 menghambat proliferasi sel kanker, 8 menurunkan kolesterol total dan meningkatkan HDL kolesterol secara signifikan, 9 efek antibakteri, 10 antifungi, 11 anti inflamasi, 12 efek hipotensif, 13 anti konvulsif, 14 dan mengandung antioksidan. 15 Diantara kandungan kimia yang ditemukan pada tumbuhan A. muricata antara lain alkaloid , minyak atsiri, flavonol triglikosida, fenolik dan siklopeptida.…”

Section: Abstrakunclassified

Aktifitas Hepatoprotektif Ekstrak Etanol Daun Sirsak (Annona Muricata L.) Terhadap Kerusakan Hati Tikus yang Diinduksi dengan Parasetamol

Zakiah

Yanuarman

Frengki

et al. 2017

AcTion

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For a long period, the therapy of liver diseases that carried out against liver diseases is still a challenge for modern medicine. The drugs used in the treatment of liver diseases such as antiviruses, diuretics, and antibiotics could cause some serious side effects. Annona muricata plants or better known as soursop plant has long been widely used as traditional medicine. This study was aimed to determine the hepatoprotective effects of ethanol extract of soursop (Annona muricata L.) leaves on liver histologist pattern of the mice of Sprague-Dawley thread that exposed to high doses of paracetamol. The dosages of the ethanol extract of soursop leaves of 200 mg/Kg BW, 400 mg/Kg BW and 600 mg/Kg BW orally for 14 days, then 2 hours after induction of final dose, induced with paracetamol 2.5 g/kg BW orally. Furthermore, through the observation of mice liver histologic, the level of damages in mice liver cells, including conditions of hepatocytes, necrosis, pyknocytosis, karyorrhexis, karyolysis were recorded. The results showed that ethanol extract of soursop leaves with a dose of 600 mg/kg BW showed significant hepatoprotective effects characterized by a relatively normal hepatocytes condition after exposure to high doses of paracetamol. The final conclusion was that the ethanol extract of soursop leaves provide hepatoprotective effects.Keywords: Annonamuricata L., hepatoprotective, paracetamol, liver histologySelama ini terapi yang dilakukan terhadap penyakit hati masih merupakan tantangan bagi pengobatan modern. Obat-obat yang biasa digunakan pada pengobatan penyakit hati diantaranya adalah antivirus, diuretic dan antibiotik yang dapat menimbulkan beberapa efek samping yang serius. Tumbuhan Annona muricata (sirsak) telah lama digunakan sebagai obat tradisional yang luas. Penelitian ini bertujuan untuk mengetahui efek hepatoprotektif ekstrak etanol daun sirsak (Annona muricata L.) terhadap gambaran histologis hati tikus putih galur Sprague dawley yang terpapar parasetamol dosis tinggi. Dosis yang digunakan adalah ekstrak etanol daun sirsak (EEDS) dosis 200 mg/kg BB, 400 mg/kg BB dan 600 mg/kg BB per oral selama 14 hari, kemudian 2 jam setelah pemberian dosis akhir, diinduksi dengan parasetamol 2,5 g/kg BB per oral. Selanjutnya dilakukan pengamatan histologi hati tikus, dicatat tingkat kerusakan pada sel hati tikus, meliputi kondisi hepatosit, nekrosis, piknositosis, karioreksis, kariolisis. Hasil penelitian menunjukkan bahwa ekstrak etanol daun sirsak dosis 600 mg/kg BB memperlihatkan efek hepatoprotektif yang signifikan yang ditandai dengan kondisi hepatosit yang relatif normal setelah terpapar dengan dosis tinggi parasetamol. Dari hasil penelitian disimpulkan pemberian ektrak etanol daun sirsak memberikan efek hepatoprotektifKata kunci: Annona muricata L., hepatoprotektif, parasetamol, histologi hati

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“…According to Dalimartha [6], Papaya contains papain. Flavonoids can reduce blood cholesterol levels by increasing the excretion of bile acids and reducing blood viscosity, thereby reducing the occurrence of deposition of fat in blood vessels [7]. According to Haris [8], flavonoids are compounds consisting of 15 carbon atoms which are useful as cholesterol-lowering and as an antibiotic.…”

Section: Introductionmentioning

confidence: 99%

Effect ofCarica papayaL. Stem Bark Extracts on Cholesterol Concentration in Rats Induced with Streptosozin

Safrida

Sabri

2020

E3S Web Conf.

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This study was designed to determine the effect of Carica papaya L. stem bark extracts on cholesterol concentration in rats induced with glibenclamide. A completely randomized design was used for the experiment which consisted of 6 treatment groups, each group consisted of four rats, as follows:1) KN (negative control, non-diabetic rats); KP, diabetic rats given glibenclamide 10 mg/kg body weight; EP 1, diabetic rats given 0 mg/kg body weight/day extract; EP2, diabetic rats given 100 mg/kg body weight/day extract; and EP3, diabetic rats given 200 mg/kg body weight/day extract, EP4, diabetic rats given 300 mg/kg body weight/day extract for 28 day. The results showed that C. papaya L. stem bark extract decreased (P<0.05) cholesterol levels in diabetic rats. It was concluded that C. papaya L. stem bark extract had potential as anti-hypercholesterolemic in diabetic rats.

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Efek ekstrak daun sirsak (Annona muricata Linn) terhadap profil lipid tikus putih jantan (Rattus Norvegicus)

Cited by 11 publications

References 12 publications

Soursop fruit ( Annona muricata Linn.) consumption does not increase serum potassium levels and not significant in cardiovascular risk improvements of prehypertension subjects

Soursop fruit ( Annona muricata Linn.) consumption does not increase serum potassium levels and not significant in cardiovascular risk improvements of prehypertension subjects

Aktifitas Hepatoprotektif Ekstrak Etanol Daun Sirsak (Annona Muricata L.) Terhadap Kerusakan Hati Tikus yang Diinduksi dengan Parasetamol

Effect ofCarica papayaL. Stem Bark Extracts on Cholesterol Concentration in Rats Induced with Streptosozin

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