EFEK EKSTRAK ETANOL HERBA CECENDET (Physalis angulata L.) PADA KADAR PROTEINURIA HEWAN MODEL LUPUS ERITEMATOSUS SISTEMIK

Combination Effect of Cecendet (Physalisangulata L.) Extract and Methylprednisolone in Reducing Inflammation and Improving Renal Functions in Pristane-induced Lupus Rat Models

“…15 Administration of cecendet extract at a lower dose such as 50 mg/kg BW determined that the effect of cecendet ethanolic extract on week 7 could reduce proteinuria level when compared to the control group (p<0.1) and it was at the same level as a the comparison of cyclophosphamide (p>0.1). 10 Interval period should be considered while giving a combination of cecendet extract and methylprednisolone of each composition. In a previous study, a 30 minute interval period was considered insufficient because any interaction may occur, hence, the administration should be separately given minimum 2 hours of interval period.…”

“…The pristane can cause cell death through lymphoid cell apoptosis in the peritoneal cavity leading to autoimmune disease induction, which is marked by the presence of positive antinuclear of antibody after a 4-week induction. 8,10 The animal models were randomly divided into 4 groups (each group consisted of 5 rats): normal group, control group which was given Na CMC 2% of suspension; group of cecendet extract at the dose 62.5 mg/kg BW (daily and orally given); group of combination of cecendet extract at the dose 62.5 mg/kg BW and Serum creatinine level examination was performed by collecting blood veins from the tail of the rats and placed in eppendorf tube. The bloods were centrifuged 5000 rpm during 6 minutes.…”

“…The extract works primarily on specific immune response by lowering immune response approaching normal condition, not by suppressing immune response as prednisone. [8][9][10] The animal models was induced by Pristane, an intraperitoneal hydrocarbon compound to induce lupus. The pristane can cause cell death through lymphoid cell apoptosis in the peritoneal cavity leading to autoimmune disease induction which is marked by the presence of positive antinuclear of antibody after a 4-week induction.…”