2017
DOI: 10.24198/ijas.v7i2.13707
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EFEK IMUNOMODULATOR EKSTRAK ETANOL KULIT BUAH NANAS (Ananas comosus L.Merr) TERHADAP MENCIT PUTIH JANTAN DENGAN METODE BERSIHAN KARBON (Carbon Clearance)

Abstract: This research was aimed to study the immunomodulatory effect of ethanol extract of pineapple (Ananas comosus L. Merr) peel on white male mice with carbon clearance method. Animals  were divided into 5 groups: Group 1 was given tween 80 1 % v/v;Ggroup 2 was given meniran extracts; Group 3, 4 and 5 were given  ethanol extracts of pineapple peel with a dose of 125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW,respectively, for 6 days orally. On the 7th day the animals were injected with carbon suspension 0.2 ml/20g BW… Show more

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Cited by 2 publications
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“…The selection of BALB/c strain mice is because this strain provides a good and representative level of immunity response sensitivity, both for testing and observing specific and non-specific immune responses. The use of male sex mice is based on this mice having fewer reproductive hormones compared to female mice, so it is hoped that there will be fewer variations that can affect the results of the study [15,32,33]. Various studies on animal models of BALB/c strain mice test for testing immunomodulatory activity have also been widely carried out [9,20,34].…”
Section: Carbon Clearance Test Results In Balb/c Strain Male Micementioning
confidence: 99%
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“…The selection of BALB/c strain mice is because this strain provides a good and representative level of immunity response sensitivity, both for testing and observing specific and non-specific immune responses. The use of male sex mice is based on this mice having fewer reproductive hormones compared to female mice, so it is hoped that there will be fewer variations that can affect the results of the study [15,32,33]. Various studies on animal models of BALB/c strain mice test for testing immunomodulatory activity have also been widely carried out [9,20,34].…”
Section: Carbon Clearance Test Results In Balb/c Strain Male Micementioning
confidence: 99%
“…Thus, if there is immunostimulating activity, there will be a greater decrease in carbon ink absorbance at each time interval. The absorbance value will then be entered into an equation to find out the phagocytic constant, the greater the K value, the better the activity in stimulating the body's immune system to eliminate carbon that has been injected [15,42,43].…”
Section: Carbon Clearance Test Results In Balb/c Strain Male Micementioning
confidence: 99%
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