EFEKTIFITAS GEL DAUN SIRIH MERAH (Piper crocatum) PADA PERAWATAN  PERIODONTITIS KRONIS

Sidiqa, Atia Nurul; Herryawan, Herryawan

doi:10.26874/kjif.v5i1.81

Cited by 3 publications

(3 citation statements)

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“…The chip combination of snakehead fish and betel leaf extract can be an antimicrobial agent, so it can help SRP act to reduce inflammation caused by periodontitis [16]. The results of Achmad et al's research stated that snakehead fish extract (Channa striata) has an antibacterial effect on peri-pathogenic bacteria.…”

Section: Discussionmentioning

confidence: 99%

COMBINED CHIP APPLICATION'S EFFECT OF CLINICAL PARAMETERS AND TNF-α EXPRESSIONS

JASMANIAR,

NASUTION,

ILYAS

et al. 2024

Int J App Pharm

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Objective: Scaling root planing is the main mechanical treatment to remove local deposits. Supportive local and systemic antimicrobial therapy is used to eliminate or reduce the number of pathogenic bacteria. The chip application of the combination of snakehead fish extract and betel leaf can change the clinical parameters for the better and increase the expression of TNF-α as a pro-inflammatory. To see the effect of the application of a chip combination of snakehead fish extract and betel leaf in male Wistar rats induced by periodontitis as a support for initial therapy on clinical parameters and expression of TNF-α. Methods: Laboratory experimental study with a posttest control group design in which 24 male Wistar rats induced periodontitis were in four treatment groups (2.5%, 5%, 10% snakehead fish extract and placebo). Examination of clinical parameters and expression of TNF-α was carried out on day 0, day 3 and day 7. Data were analyzed by the Mann-Whitney test. Results: The results showed that the clinical parameters; gingival index, pocket depth and attachment level looked better on the 7th day after treatment with statistically significant results (p≤0.05) and the highest anti-inflammatory TNF-α expression occurred at a concentration of 5%. Conclusion: The application of a chip combination of snakehead fish extract and betel leaf as a support for initial therapy is effective in reducing the gingival index pocket depth and increasing the level of attachment, which is statistically significant, but there is no significant difference in TNF-α expression.

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Section: Discussionmentioning

confidence: 99%

COMBINED CHIP APPLICATION'S EFFECT OF CLINICAL PARAMETERS AND TNF-α EXPRESSIONS

JASMANIAR,

NASUTION,

ILYAS

et al. 2024

Int J App Pharm

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“…Pemberian antimikroba secara sistemik akan memerlukan dosis yang tinggi sehingga memiliki efek samping yang lebih besar seperti sensitivitas, kerusakan pada alat pencernaan, resistensi bakteri dan munculnya infeksi oportunistik 14 . Pemberian antimikroba secara lokal memiliki keuntungan yaitu dapat mengurangi konsumsi obat secara berkesinambungan, memungkinkan pemberian obat dalam jangka panjang dan dapat diletakkan langsung di daerah aktivitas penyakit pada konsentrasi bakterisida 14,15 . Antimikroba lokal yang tersedia dalam periodontologi adalah metronidazole, chlorhexidine, chlortetracycline, doxycycline, dan minocycline 16 .…”

Section: Andalas Dental Journalunclassified

“…Gel metronidazole merupakan salah satu antibiotik lokal yang paling sering digunakan untuk perawatan periodontal karena memiliki kemampuan yang baik untuk mengatasi bakteri anaerob dengan sedikit efek samping, akan tetapi peredaran gel metronidazole dipasaran masih sedikit karena gel ini sulit didapat dan harganya yang relatif mahal 15 .…”

Section: Andalas Dental Journalunclassified

Uji Daya Hambat Ekstrak Daun Salam (Syzygium polyanthum wight) Terhadap Pertumbuhan Bakteri Porphyromonas Gingivalis Secara In Vitro

Monalisa¹,

Erly²,

Fransiska³

2022

Andalas Dent. J.

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Chronic periodontitis is the most common type of periodontitis. The main cause of chronic periodontitis is bacterial colonization of plaque. Porphyromonas gingivalis is the main pathogen and has the highest prevalence of chronic periodontitis. Bay leaf extract (Syzygium polyanthum wight) is believed to have the pharmacological effect that can be used as antibacterial. The purpose of this research was to determine the inhibitory of bay leaf extract on the growth of Porphyromonas gingivalis in vitro. The method of this research was experimental laboratories with posttest only control group design. There were 30 samples divided into 6 groups, namely bay leaf extract concentration of 2.5%, 5%, 10%, 20%, 40% and Dimethyl Sulfoxide (DMSO) as a control. Inhibitory test using the Kirby-Bauer method with a paper disc on Mueller Hinton medium agar. Inhibition zone that created around paper disc was measured with the sliding caliper. The results were analyzed with One Way Anova and Post Hoc LSD test. The results of this research showed that the mean of bay leaf extract 40% had the largest inhibition zone that was 7,6 mm and the lowest formed by bay leaf extract 2,5% that was 1,94 mm. One Way Anova test showed that there was a significant difference among the group (p<0,05). The conclusion of this research there was significant difference inhibition among 2,5%, 5%, 10%, 20%, and 40% concentration of bay leaf extract on the growth of Porphyromonas gingivalis in vitro. The higher concentration of bay leaf extract resulting the greater inhibition zone.

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