Cooking oil is an important basic ingredient in the frying process with the main function as a medium for conducting heat, adding savory taste, in-creasing nutritional value and heating food ingredients. The massive use of cooking oil also has an impact on the waste produced, namely used cooking oil (UCO), which is more increasing. The sustainable use of used cooking oil can damage health. The aim of this study was to obtain purification of used cooking oil with coffee dregs and bagasse as raw materials for making antiseptic transparent soap with guava leaf extract. Preparation of raw materials, extraction of guava leaves, oil refining process, production of antiseptic transparent soap with guava leaf extract, and sample quality analysis are the stages of research. The data from the analysis was then tested with ANOVA. Purification of used cooking oil using bagasse adsorbent produced oil with a pH value of 6.43-6.86, moisture content of 0.67-0-769%, free fatty acids of 0.301-1.982% and acid value of 2.3-3.490%, while for the type of coffee dregs adsorbent produced oil with a pH value of 6.60-6.83, moisture content of 0.068-0.549%, free fatty acids of 0.292-0.921 and acid value of 1.120-5.850. The antiseptic transparent soap formulation results obtained a pH value of 11.427-13,687, moisture content of 27.78-36.505, foam height of 19-21.5 mm and antiseptic power of 2-12 colonies.