Effect Analysis of Simotang Oral Liquid on Functional Dyspepsia of Incoordination between the Liver and the Spleen and Gastrointestinal Hormone

Abstract

This paper investigates the effect of Simotang oral liquid on functional dyspepsia of incoordination between the liver and the spleen and gastrointestinal hormone. The research objects were the 100 patients with functional dyspepsia treated in our hospital from January 2014 to October 2015. They were randomly divided into observation group (n = 50 cases) and control group (n = 50 cases) according to even number-odd method. The control group were treated with domperidone tablets in the treatment, and the observation group were treated with Simotang oral liquid. After 2 weeks of treatment, compare the motilin, gastric emptying situation and symptoms as well as plasma substance P of two groups of patients. The overall response rate of functional dyspepsia of incoordination between the liver and the spleen for observation group was 80% while the control group was 72%. Compare the two groups, we can see the difference was not statistically significant, p> 0.05. After treatment, the nausea, epigastric fullness and abdominal pain and other symptoms of patients were significantly lower than that before treatment, and the difference was significant, which was statistically significant, p> 0.05. The observation group was significantly better than the control group, and the difference was significant, which was statistically significant, p> 0.05. The total effective rate of gastric emptying in patients in the observation group was 76%, and that in the control group was 68%, respectively. The difference was not statistically significant, p> 0.05. That patients with functional dyspepsia of incoordination between the liver and the spleen use Simotang oral treatment is safe and effective, which can effectively promote gastrointestinal emptying and regulate motilin and substance P.

Exploring the Active Components of Simotang Oral Liquid and Their Potential Mechanism of Action on Gastrointestinal Disorders by Integrating Ultrahigh-Pressure Liquid Chromatography Coupled with Linear Ion Trap-Orbitrap Analysis and Network Pharmacology

“…(LK) at the weight ratio of 3:2:3:3 . Modern pharmacological and clinical studies have revealed that SMT exerts significant therapeutic effects on functional dyspepsia, 11 the contraction of antral circular smooth muscle, 12 and constipation-predominant irritable bowel syndrome. 13 However, the underlying complex mechanisms of SMT acting on GIDs remain unclear.…”