Effect and mechanism of β-L-D4A on DNA polymerase α

Abstract

AIM:To investigate the safety of β-L-D4A on DNA polymerase α. METHODS:Ion exchange chromatography was used to separate DNA polymerase α from crude extract of human Hela cells. Detailed kinetic parameters were determined for β-L-D4A against DNA polymerase α. RESULTS:

Editorial: The effect of gut microbiota on the brain structure and function

“…The effects of heavy metals on human health are well-known. Studies showed that heavy metal could impair microbiota-gutbrain axis (Lin et al, 2020;Sun et al, 2022;Yu et al, 2022) while probiotics and prebiotics alleviated the damage (Nagano et al, 2021;Yao et al, 2022;Zhang et al, 2023). The following study shows early lead exposure not only disturbed gut microbiota but also impaired mental health.…”