Effect and Regulation of the NLRP3 Inflammasome During Renal Fibrosis

Zhang, Hong; Wang, Zhengchao

doi:10.3389/fcell.2019.00379

Cited by 65 publications

(40 citation statements)

References 92 publications

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“…TGF-β/Smad signalling pathway has been reported as an important contributor to renal fibrosis [ 116 ]. Likewise, the pro-fibrogenic effect of pyroptosis has been highlighted due to its association with TGF-β/Smad signalling pathway, while activated NLRP3 inflammasome seems to be the bridge between them [ 117 ]. In patients with DKD, the production of NLRP3 inflammasome correlates with glomerulosclerosis, interstitial fibrosis and tubular atrophy [ 118 ].…”

Section: Pathological Role Of Pyroptosis In Dkdmentioning

confidence: 99%

“…TGF-β/Smad signalling pathway can upregulate expression NLRP3, trigger the NLRP3/caspase-1/IL-1β/IL-18 axis and pyroptosis. NLPR3 inflammasome also facilitates the TGF-β/Smad pathway by promoting Smad2/3 phosphorylation which is mediated by TGF-β [ 117 ] ( Figure 5 ). This proposal was supported by animal models studies, which indicated that NLRP3 gene knockout greatly improved renal function [ 17 ].…”

Section: Pathological Role Of Pyroptosis In Dkdmentioning

confidence: 99%

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New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease

Lin

Cheng

et al. 2020

IJMS

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Pyroptosis is one special type of lytic programmed cell death, featured in cell swelling, rupture, secretion of cell contents and remarkable proinflammation effect. In the process of pyroptosis, danger signalling and cellular events are detected by inflammasome, activating caspases and cleaving Gasdermin D (GSDMD), along with the secretion of IL-18 and IL-1β. Pyroptosis can be divided into canonical pathway and non-canonical pathway, and NLRP3 inflammasome is the most important initiator. Diabetic kidney disease (DKD) is one of the most serious microvascular complications in diabetes. Current evidence reported the stimulatory role of hyperglycaemia-induced cellular stress in renal cell pyroptosis, and different signalling pathways have been shown to regulate pyroptosis initiation. Additionally, the inflammation and cellular injury caused by pyroptosis are tightly implicated in DKD progression, aggravating renal fibrosis, glomerular sclerosis and tubular injury. Some registered hypoglycaemia agents exert suppressive activity in pyroptosis regulation pathway. Latest studies also reported some potential approaches to target the pyroptosis pathway, which effectively inhibits renal cell pyroptosis and alleviates DKD in in vivo or in vitro models. Therefore, comprehensively compiling the information associated with pyroptosis regulation in DKD is the main aim of this review, and we try to provide new insights for researchers to dig out more potential therapies of DKD.

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Section: Pathological Role Of Pyroptosis In Dkdmentioning

confidence: 99%

Section: Pathological Role Of Pyroptosis In Dkdmentioning

confidence: 99%

New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease

Lin

Cheng

et al. 2020

IJMS

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“…Atorvastatin was found to effectively suppress NLRP3 inflammasome level in CAD (Satoh et al, 2014). Certain antidiabetic medicines such as biguanides, thiazolidinediones, and inhibitors of dipeptidyl peptidase 4 have the potential to regulate the activation of NLRP3 inflammasome (Zhang and Wang, 2020). An antioxidant, melatonin, could also function as an anti-inflammatory agent by inhibiting the activity of NLRP3 inflammasome (Garcia et al, 2015).…”

Section: Therapeutic Targeting Of Nlrp3 Against Rihdmentioning

confidence: 99%

The Role of NLRP3 Inflammasome in Radiation-Induced Cardiovascular Injury

Huang

Che

Chu

et al. 2020

Front. Cell Dev. Biol.

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The increasing risk of long-term adverse effects from radiotherapy on the cardiovascular structure is receiving increasing attention. However, the mechanisms underlying this increased risk remain poorly understood. Recently, the nucleotide-binding domain and leucine-rich-repeat-containing family pyrin 3 (NLRP3) inflammasome was suggested to play a critical role in radiation-induced cardiovascular injury. However, the relationship between ionizing radiation and the NLRP3 inflammasome in acute and chronic inflammation is complex. We reviewed literature detailing pathological changes and molecular mechanisms associated with radiation-induced damage to the cardiovascular structure, with a specific focus on NLRP3 inflammasome-related cardiovascular diseases. We also summarized possible therapeutic strategies for the prevention of radiation-induced heart disease (RIHD).

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“…This pattern of inflammatory cell death is known as pyroptosis. The mechanism of occurrence and regulation is different from that of apoptosis, necrosis, and other ways of cell death [56,57]. Several studies have showed that inflammasomes are closely related to kidney diseases, including the NOD-and LRR-pyrin domain-containing 3 (NLRP3) inflammasome, especially NLRP3, which play a role in regulating kidney inflammation and fibrosis [58].…”

Section: Regulating the Pyroptosis Inflammatory Activation Usually mentioning

confidence: 99%

The Effect of Chinese Traditional Medicine Huaiqihuang (HQH) on the Protection of Nephropathy

Zhang

Cheng

Zhou

et al. 2020

Oxidative Medicine and Cellular Longevity

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Kidney disease is one of the common diseases with high morbidity and high mortality, which brings a huge burden to the society and the patient’s family. The pathogenesis, treatment, and prognosis of kidney diseases are related to oxidative stress, inflammation, mitochondrial damage, and immune dysfunction. However, existing treatments always cause some damage to the kidneys. Kidney disease and immunosuppressant used together often lead to drug toxicity, patients with weakened immunity, organic rupture of the normal structure of the kidney, damage to the physiological function of the kidney, etc. Huaiqihuang is a kind of traditional Chinese medicine with a history of more than one thousand years. According to research, Robinia pseudoacacia can regulate the immune function by regulating oxidative stress, calcium inflow, and mitochondrial ATP. At the same time, it is also involved in regulating the ways of cell death, such as apoptosis, autophagy, ferroptosis, pyroptosis, and clockophagy, to reduce kidney damage, which has important clinical value. This article reviews the exact mechanism and clinical application of Huaiqihuang in different types of nephropathy. The aim is to provide new ideas for the treatment of clinical nephropathy.

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Effect and Regulation of the NLRP3 Inflammasome During Renal Fibrosis

Cited by 65 publications

References 92 publications

New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease

New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease

The Role of NLRP3 Inflammasome in Radiation-Induced Cardiovascular Injury

The Effect of Chinese Traditional Medicine Huaiqihuang (HQH) on the Protection of Nephropathy

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