2003
DOI: 10.1016/s0006-8993(02)04191-4
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Effect of 17β-estradiol on gene expression in lumbar spinal cord following sciatic nerve crush injury in ovariectomized mice

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Cited by 45 publications
(34 citation statements)
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“…Their results have demonstrated that estrogen promotes regeneration of the sciatic nerve after crush injury. The data of Islamov et al (2003) suggest that estrogen could be one of the critical factors regulating transcription of genes involved in nerve regeneration and also estrogen promotes regeneration locally. In another study it is shown that after injury of sciatic nerve, estrogen suppresses the scar reaction (Nachemson et al 1985).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Their results have demonstrated that estrogen promotes regeneration of the sciatic nerve after crush injury. The data of Islamov et al (2003) suggest that estrogen could be one of the critical factors regulating transcription of genes involved in nerve regeneration and also estrogen promotes regeneration locally. In another study it is shown that after injury of sciatic nerve, estrogen suppresses the scar reaction (Nachemson et al 1985).…”
Section: Discussionmentioning
confidence: 99%
“…Strong biological evidence supports the benefits of estrogens in several experimental models of neurodegeneration (GarciaSegura et al 2001). Beneficial effects of estrogens in peripheral nervous system are also shown in several studies (Islamov et al 2002;Islamov et al 2003;Nachemson et al 1985). Although insulin is known to regulate the activity of aromatase (Garzo and Dorrington 1984;Nestler 1993) there is no data about the immunoreactivity levels of this enzyme in diabetes and also the levels of aromatase in hippocampus and sciatic nerves of diabetic animals.…”
Section: Introductionmentioning
confidence: 99%
“…In the peripheral nervous system, estrogen receptors are found in the spinal cord [12][13][14][15], dorsal root ganglia [16][17][18][19], autonomic pelvic ganglia [14,15], sympathetic ganglia [20,21], and Schwann cells [22]. Numerous studies have shown that estrogens affect the nervous system via both genomic and non-genomic mechanisms, including the development, proliferation, and regeneration of neuronal cells, gene expression, energy metabolism, hormone sensitivity, and the biosynthesis of structural proteins and enzymes [12,15,17,19,23]. The hormonal changes that accompany menopause (i.e., decreased estrogen levels) have a significant impact on the nervous system and other physiological systems.…”
Section: Discussionmentioning
confidence: 99%
“…Although ERb has not been directly assessed in the sciatic nerves of adult animals, its expression is very low in Schwann cells cultured from sciatic nerves of neonatal rats [61]. However, the expression of ERb is increased in motor neurons of the spinal cord after sciatic nerve injury [62], and may therefore be involved in the mechanisms of nerve regeneration. Another possible pathway mediating the effect of 3a-diol could be the interaction with GABA-A receptor [63,64], which is present both in sciatic nerve and in Schwann cells [65].…”
Section: Discussionmentioning
confidence: 99%