Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on heme oxygenase-1, biliverdin IXα reductase and δ-aminolevulinic acid synthetase 1 in rats with wild-type or variant AH receptor

Genetic Ablation of the Aryl Hydrocarbon Receptor Causes Cigarette Smoke-induced Mitochondrial Dysfunction and Apoptosis

“…7). These were surprising results, as activation of the AhR induces rat hepatic HO-1 (62). Also intriguing was the lack of association between AhR expression and Nrf2 activation.…”

Inhibitory Effects of Palm Tocotrienol-Rich Fraction Supplementation on Bilirubin-Metabolizing Enzymes in Hyperbilirubinemic Adult Rats

“…The enzyme catalyzes the condensation of glycine and succinyl-CoA which produces aminolevulinic acid [38] and is regulated by cellular heme content [25]. Induction of the hepatic enyzme following an exposure to phenylhydrazine, was reported to be accompanied by a reduction in hepatic glutathione content, an endogenous antioxidant and an increase in heme content [8].…”

“…Liver microsomes were prepared prior to biliverdin reductase activity measurement following established methods [24], [25]. The enzyme activity was determined by the method of Niittynen et al [25].…”

“…The enzyme activity was determined by the method of Niittynen et al [25]. A reaction mixture with a total volume of 3.08 ml containing Tris (10 mM, pH 8), biliverdin (10 µM), and 2–6 mg/ml protein of sample cytosol was immediately mixed and read at 460 nm for a minute to record the blank rate.…”

Protective effects of curcumin on antioxidant status, body weight gain, and reproductive parameters in male rats exposed to subchronic 2,3,7,8-tetrachlorodibenzo-p-dioxin

“…Introduction 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most toxic congener among the polychlorinated dibenzo-p-dioxins, which are widespread, persistent and highly toxic environmental pollutants, and TCDD has been widely investigated as a model compound of this class of chemicals (Ishida et al 2004;Niittynen, Tuomisto, and Pohjanvirta 2008). Prolonged exposure to TCDD may result in a wide variety of adverse health effects in laboratory animals and in humans, including wasting syndrome, dermal toxicity, reproductive toxicity, immunotoxicity, neurotoxicity, hepatotoxicity, teratogenesis, and carcinogenesis (National Toxicology Program 2006).…”