Protective effects of curcumin on antioxidant status, body weight gain, and reproductive parameters in male rats exposed to subchronic 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin

Bulmus, Funda Gulcu; Sakin, Fatih; Türk, Gaffari; Sönmez, Mustafa; Servi, Kadir

doi:10.1080/02772248.2013.829061

Cited by 6 publications

(5 citation statements)

References 42 publications

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“…19,22,23 Environmental pollutants, such as carbon tetrachloride, 2,3,7,8-tetrachlorodibenzo-pdioxin and polychlorinated biphenyl, can result in testicular histopathological lesions and decreased reproductive organ weights. [24][25][26][27][28] In the present study, PFOA-induced testicular damage in mice was evidenced by decreased testicular weight, reduced epididymal sperm count and disorganized seminiferous epithelium, which might be consequences of elevated oxidative stress and excessive apoptosis in the testis. It has been demonstrated that PFOA exposure reduces testosterone biosynthesis and production.…”

Section: Discussionmentioning

confidence: 48%

Attenuation of perfluorooctanoic acid-induced testicular oxidative stress and apoptosis by quercetin in mice

Yuan

et al. 2017

RSC Adv.

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Section: Discussionmentioning

confidence: 48%

Attenuation of perfluorooctanoic acid-induced testicular oxidative stress and apoptosis by quercetin in mice

Yuan

et al. 2017

RSC Adv.

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“…In fact, Cur I seem to restore the body weight deficit occurring in Pb intoxicated pups progressively from P1 to young stages. Previous data seemed to corroborate such find in rat and mice, in which, treatment with Cur I (100 mg/kg) reversed the loss of body weight induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) [ 78 , 79 , 80 ]. Such property of Cur I could be due to its possible action on the digestive system including hepatopancreas and intestines.…”

Section: Discussionmentioning

confidence: 68%

Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I

et al. 2017

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Lead poisoning is one of the most significant health problem of environmental origin. It is known to cause different damages in the central and peripheral nervous system which could be represented by several neurophysiological and behavioral symptoms. In this study we firstly investigated the effect of lead prenatal exposure in rats to (3g/L), from neonatal to young age, on the motor/sensory performances, excitability of the spinal cord and gaits during development. Then we evaluated neuroprotective effects of curcumin I (Cur I) against lead neurotoxicity, by means of grasping and cliff avoidance tests to reveal the impairment of the sensorimotor functions in neonatal rats exposed prenatally to lead. In addition, extracellular recordings of motor output in spinal cord revealed an hyper-excitability of spinal networks in lead treated rats. The frequency of induced fictive locomotion was also increased in treated rats. At the young age, rats exhibited an impaired locomotor gait. All those abnormalities were attenuated by Cur I treatment at a dose of 16g/kg. Based on our finding, Cur I has shown features of a potent chemical compound able to restore the neuronal and the relative locomotor behaviors disturbances induced by lead intoxication. Therefore, this chemical can be recommended as a new therapeutic trial against lead induced neurotoxicity.

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“…Many reports revealed that curcumin has these pharmacological activities because of its basic beneficial antioxidant, antiinflammatory, antibacterial, and anticancer activities (10,11). Regarding to the antioxidant role, curcumin has been demonstrated to have an effective scavenging property on various harmful free radicals which not only ROS but also nitrogen dioxide radicals, superoxide anions and hydroxyl radicals (12). Curcumin also displayed the high binding affinity on metal ions that related to the ROS formation especially on the iron chelating ability (13).…”

Section: Introductionmentioning

confidence: 99%

Comparison and combination effects on antioxidant power of curcumin with gallic acid, ascorbic acid, and xanthone

Naksuriya

Okonogi

2015

DD&T

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Curcumin has been extensively reported as a potential natural antioxidant. However, there was no data on activity comparison as well as the biological interactions of curcumin with other natural antioxidants. The aim of the present study was to investigate the antioxidant power of curcumin in comparison with three important natural antioxidants; gallic acid, ascorbic acid, and xanthone on free radical scavenging action and their combination effects on this activity. The results indicated that the activities of these compounds were dose-dependent. The 50% effective concentration (EC50) of curcumin was found to be 11 μg/mL. Curcumin showed significantly higher antioxidant activity than ascorbic acid and xanthone but less than gallic acid. Interestingly, curcumin revealed synergistic antioxidant effect when combined with gallic acid whereas the antagonistic effect occurred in curcumin combination with ascorbic acid or xanthone. These results suggest that curcumin-gallic acid combination is the potential antioxidant mixture to be used in place of the individual substance whereas using of curcumin in combination with ascorbic acid or xanthone should be avoid.

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Protective effects of curcumin on antioxidant status, body weight gain, and reproductive parameters in male rats exposed to subchronic 2,3,7,8-tetrachlorodibenzo-p-dioxin

Cited by 6 publications

References 42 publications

Attenuation of perfluorooctanoic acid-induced testicular oxidative stress and apoptosis by quercetin in mice

Attenuation of perfluorooctanoic acid-induced testicular oxidative stress and apoptosis by quercetin in mice

Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I

Comparison and combination effects on antioxidant power of curcumin with gallic acid, ascorbic acid, and xanthone

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