Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgery

Schneemilch, C.; Ittenson, A; Ansorge, Siegfried; Hachenberg, Thomas; Bank, Ute

doi:10.1016/j.jclinane.2004.12.017

Cited by 95 publications

(87 citation statements)

References 33 publications

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“…Although our analysis in this study does not resemble to those of the above mentioned studies, we have aimed to underline the effect of the method of anaesthesia on N/L ratios. In previous studies, results similar to our findings have been reported showing propofol and sufentanil anaesthesia to be more effective than sevoflurane anaesthesia in reducing lymphocyte apoptosis rate in partial discectomy surgery (18). Analyses on cytokine responses (7) and auxiliary T1 cells/T2 cells (8) ratios (Th1/Th2) following major surgical procedures have shown that intravenous anaesthesia surgery is more effective than inhalation anaesthesia in terms of reducing adverse immune response induced by stress.…”

Section: Resultssupporting

confidence: 91%

Comparison of the Effects of Propofol Anaesthesia and Desflurane Anaesthesia on Neutrophil/Lymphocyte Ratios After Coronary Artery Bypass Surgery

2015

J Turgut Ozal Med Cent

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Objective: Coronary artery bypass surgery with cardiopulmonary bypass can induce postoperative systemic leukocytic alterations including leukocytosis, neutrophilia, or lymphopenia. The present study aims to compare the effects of propofol and desflurane anaesthesia on the leukocytic alterations including neutrophil-to-lymphocyte ratios after coronary artery bypass surgery. Materials and Methods: Sixty patients scheduled for coronary artery bypass surgery were randomly assigned into two groups: group P (n=30), which were anaesthesised with propofol (intravenous anaesthesia) and group D, which were anaesthesised with desflurane (inhalational anesthesia). Differential counts of leukocytes with neutrophil/lymphocyte ratios of peripheral blood were obtained just before anaesthesia induction (for basal values), at the postoperative 12th, 24th, and 48th hours. Results: At the postoperative 12th decrease in lymphocyte counts in group P was significantly lower than in group D (1.23 ± 0.81, 0.92 ± 1.01, respectively, with a p value of <0.001). Depending on this difference, neutrophil/lymphocyte ratios in group P were lower than in group D, which was statistically significant (11.21 ± 5.01, 22.81 ± 15.24, respectively, with a p value of <0.001). At postoperative 48th hour, it was seen that the statistically significant difference between groups on the basis of lymphocyte counts and neutrophil/lymphocyte ratios dissapeared. But a statistically significant difference appeared between the two groups on the basis of neutrophil counts (in group P 6.57 ± 2.05, in group D 10.20 ± 5.26; p<0.001) Conclusion: Comparing with desflurane anaesthesia, propofol anaesthesia favorably but transiently modifies leukocytic alterations, including neutrophil-to-lymphocyte ratios in peripheral blood during postoperative period of coronary artery bypass surgery. Key Words: Coronary Artery Surgery; Propofol And Desflurane Anesthesia; Neutrophil/Lymphocyte Ratio.Propofol ve Desfluran Anestezisinin Koroner Arter By-pass Cerrahisi Sonrası Nötrofil/Lenfosit Oranı Üzerine Etkilerinin Karşılaştırılması Özet Amaç: Kardiyopulmoner by-pass ile yapılan koroner arter by-pass cerrahisi lökositoz, nötrofili ve lenfopeniyi de içeren postoperatif lökosit dağılımı değişikliklerini başlatabilir. Bu çalışma ile kardiyopulmoner bypass kullanılarak koroner by-pass cerrahisine giden hastalarda propofol (intravenöz) ve desfluran (inhalasyon) anestezisinin postoperatif lökositik değişiklikler ve nötrofil/ lenfosit oranı üzerine etkileri incelenmiştir. Gereç ve Yöntemler: Bu prospektif randomize çalışmada elektif koroner arter by-pass cerrahisi planlanan 60 hasta iki eşit gruba randomize edildi. olgulardan 30'unda (grup P, n=30) propofol (intravenöz) anestezi ve diğer 30'unda ise (grup D, n=30) desfluran (inhalasyon anestezisi kullanıldı. Hastalardan lökosit alt tipleri ve nötrofil/lenfosit oranı tayini için anestezi indüksiyonundan hemen önce (bazal değer), postoperatif 12. saat, 24. saat ve 48. saatlerde olmak üzere periferik venden kan örneği alındı. Bulgular:...

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Section: Resultssupporting

confidence: 91%

Comparison of the Effects of Propofol Anaesthesia and Desflurane Anaesthesia on Neutrophil/Lymphocyte Ratios After Coronary Artery Bypass Surgery

2015

J Turgut Ozal Med Cent

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“…Therefore, propofol may be a more appropriate anaesthetic for such patients. On the other hand, volatile anaesthetics may suppress the immune response more potently compared with propofol [20,21] and this may be a different, favourable effect in this condition.…”

Section: Discussionmentioning

confidence: 99%

Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti‐N‐methyl‐d‐aspartate receptor antibodies

Kawano¹,

Hamaguchi

Kawahito

et al. 2011

Anaesthesia

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SummaryParaneoplastic limbic encephalitis associated with ovarian teratoma has recently been related to the development of antibodies to specific heteromers of the N-methyl-D-aspartate receptor and exhibits various manifestations including psychiatric symptoms, hypoventilation, seizures and derangement of autonomic nervous system function. Although recovery can sometimes occur spontaneously, early tumour resection with immunotherapy facilitates earlier recovery. Herein, we describe anaesthetic management of a 20-year-old woman who developed general convulsions and decreased level of consciousness, whom we suspected of having paraneoplastic limbic encephalitis and was scheduled for left ovarian tumour resection. Anaesthetic management was successful with no complications but the case acts as focus of discussion for the potential interaction of N-methyl-D-aspartate receptors and anaesthetic sensitivity.

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“…However, the absolute number of T lymphocytes (CD3 + , CD4 + , CD8 + ) decreased 2 hours after sevoflurane anesthesia and until the third postoperative days (5). Besides these, the results from Ren et al study showed that propofol promoted activation and differentiation of peripheral T-helper cells.…”

Section: Discussionmentioning

confidence: 93%

“…Since increasing number of studies has been conducted to determine the role of anesthetics in the regulation of circulating January, 2017 Volume 4 Number 1 lymphocytes, evidence is rather limited with respect to the difference between intravenous anesthetics and volatile anesthetics. It was noteworthy that the inhibition of inhalation anesthetics on immune function seemed to be greater than that of intravenous anesthetics (5), as evidenced by decreased numbers of peripheral T cells in patients receiving inhalation anesthesia compared to those patients exposed to intravenous anesthesia. The previously published studies focused mainly on the impacts of anesthesia on patients undergoing the excision of breast cancer or prostate cancer (1, 6, 7), a cohort had a relatively high 5-year survival rate.…”

mentioning

confidence: 99%

Effects of Sevoflurane or Propofol on Immune Function in Patients Undergoing Hepatectomy

Gao¹,

Song²,

Zhang³

et al. 2017

J Anesth Perioper Med

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Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgery

Cited by 95 publications

References 33 publications

Comparison of the Effects of Propofol Anaesthesia and Desflurane Anaesthesia on Neutrophil/Lymphocyte Ratios After Coronary Artery Bypass Surgery

Comparison of the Effects of Propofol Anaesthesia and Desflurane Anaesthesia on Neutrophil/Lymphocyte Ratios After Coronary Artery Bypass Surgery

Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti‐N‐methyl‐d‐aspartate receptor antibodies

Effects of Sevoflurane or Propofol on Immune Function in Patients Undergoing Hepatectomy

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