Effect of 2-hydroxy 4-methoxy benzoic acid on an experimental model of hyperlipidaemia, induced by chronic ethanol treatment

Saravanan, Nadana; Nalini, Namasivayam

doi:10.1211/jpp.59.11.0011

Cited by 17 publications

(16 citation statements)

References 40 publications

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“…Our observation agrees with those of the previous researchers 28 . Increased NADH/NAD + ratio during ethanol oxidation favours FFA synthesis and increased availability of FFA may elevate TG synthesis.…”

Section: Discussionsupporting

confidence: 94%

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2011

IJPSR

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Our aim was to determine the effect of rutin, a flavonol glycoside on ethanol induced hepatic lipid accumulation in experimental rats. Male albino Wistar rats were randomized into four groups. Groups 1 and 2 received isocaloric glucose. Hepatic injury was induced in groups 3 and 4 by administering 20% ethanol via intragastric intubation for 60days. In addition, groups 2 and 4 were given rutin (100 mg/kg) daily for the last 30 days of the experiment. Ethanol alone administered rats showed a significant increase in the levels of total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), phospholipids (PL), low density lipoproteins (LDL) and very low density lipoproteins (VLDL) with a concomitant decrease in the levels of high density lipoproteins (HDL). Haematoxylin and eosin staining of the liver of ethanol alone fed rats showed inflammatory cell infiltrates and fatty changes Supplementation with rutin reversed the ethanol induced alterations in lipid profile and also restored the liver histology which appeared similar to the control rats. Together the results obtained clearly reveal the protective effects of rutin against lipid accumulation in the circulation and liver.

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Section: Discussionsupporting

confidence: 94%

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2011

IJPSR

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“…In our study, plasma LPL activity was significantly reduced in ethanol‐fed rats, which in turn could cause the accumulation of TG. Our observations are also in agreement with these reports, which show decreased activity of LPL in the plasma of ethanol‐fed rats (Saravanan and Nalini 2007). The effect of naringenin in lowering the levels of TG, VLDL and LDL may be attributed to both enhanced peripheral tissue clearance and increased plasma LPL activity.…”

Section: Discussionsupporting

confidence: 94%

Effect of Naringenin (Citrus Flavanone) on Lipid Profile in Ethanol-Induced Toxicity in Rats

Jayaraman

Nalini

2011

Journal of Food Biochemistry

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Our aim was to investigate the effect of naringenin on hyperlipidemia induced by ethanol. Groups 1 and 2 rats received isocaloric glucose and 0.5% carboxymethyl cellulose (CMC); groups 3 and 4 received 20% (6 g/kg body weight p.o.) ethanol everyday for 60 days. Groups 2 and 4 rats received naringenin (50 mg/kg body weight/day in 0.5% CMC) everyday during the last 30 days of the experiment. There were increased levels of plasma total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), very low density lipoproteins (VLDL), low density lipoproteins (LDL) and tissue TC, TG, FFA, HMG CoA reductase and alterations in collagen content of ethanol‐fed rats, which on naringenin supplementation showed decreased levels of plasma and tissue TC, TG and FFA, HMG CoA reductase and collagen content. There was a significant decrease in the levels of plasma high density lipoprotein (HDL), lipoprotein lipase (LPL) and lecithin cholesterol acyltransferase (LCAT) of ethanol‐fed rats, which on naringenin supplementation showed an increase in the levels of HDL and LPL with ethanol alone–fed rats. Naringenin can efficiently prevent the accumulation of plasma lipids and lipoproteins. PRACTICAL APPLICATIONS Alcohol abuse, alcohol intolerance, alcohol dependence and other alcohol related disabilities are some of the most challenging public health problems. A phytotherapeutic approach in the new drug development can provide many valuable drugs from traditional plant sources. The use of herbal medicines for the treatment of hepatotoxicity has gained importance throughout the world. Renewed attention to alternative medicine and natural therapies has stimulated new wave of research interest in traditional practice, and there is a need to look for more potent agents with lesser side effects. The present study is aimed to identify the efficacy of naringenin by uncovering its underlying mechanism of action against alcohol‐induced liver disease for effective therapy. Naringenin, an important flavonoid, is widely present in fruits and vegetables. Naringenin is known to possess a number of significant beneficial properties. If the biochemical and histological findings are positive, indicating the marked hepatoprotective efficacy of naringenin, it could be subjected to human trials in the future.

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“…Treatment with quercetin reduced ethanol-induced toxicity as indicated by drop in activities of marker enzymes. In alcohol intoxication, as a result of structural changes, an increase in membrane permeability to ions has been demonstrated in different animal models[20]. The increase in membrane permeability causes translocation of ALT and AST into blood circulation as shown by abnormally high level of serum hepatic markers.…”

Section: Resultsmentioning

confidence: 99%

Protective effect of quercetin in the regression of ethanol-induced hepatotoxicity

Vidhya

Indira

2009

Indian J Pharm Sci

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This study examined the protective effects of quercetin on chronic ethanol-induced liver injury. Rats were treated with ethanol at a dose of 4 g/100 g/day for 90 days. After ethanol intoxication, levels of serum amino transferases were significantly elevated. Decreased activity of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase was also observed on ethanol administration. Increased amounts of lipid peroxidation products viz. hydroperoxides, conjugated dienes and malodialdehyde were observed on ethanol intoxication. Ethanol administration resulted in significant decrease in liver glutathione content. After 90 days, the control animals were divided into two groups, the control group and the control+quercetin group. Ethanol-treated group was divided into two groups, abstention group and quercetin-supplemented group. After 30 days, the animals were sacrificed and various biochemical parameters were analyzed. The changes in enzyme activities as well as levels of lipid peroxidation products were reversed to a certain extent by quercetin. Quercetin supplementation resulted in increase of glutathione content to a significant level compared to normal abstention group. Quercetin supplemented group showed a faster recovery than abstention group. This shows the protective effect of quercetin against chronic ethanol induced hepatotoxicity. Histopathological study is also in line with these results.

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Effect of 2-hydroxy 4-methoxy benzoic acid on an experimental model of hyperlipidaemia, induced by chronic ethanol treatment

Cited by 17 publications

References 40 publications

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Effect of Naringenin (Citrus Flavanone) on Lipid Profile in Ethanol-Induced Toxicity in Rats

Protective effect of quercetin in the regression of ethanol-induced hepatotoxicity

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