Effect of Naringenin (Citrus Flavanone) on Lipid Profile in Ethanol-Induced Toxicity in Rats

Jayaraman, Jayachitra; Nalini, Namasivayam

doi:10.1111/j.1745-4514.2011.00561.x

Cited by 35 publications

(19 citation statements)

References 46 publications

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“…Naringenin is a phenolic compound belonging to the flavanone class, and its three‐ring structure effects a low water solubility . Although naringenin has been shown to display anti‐cancer, anti‐inflammatory, and anti‐microbial activities, the low water solubility limits its pharmaceutical application. The solubility of naringenin was improved 365‐ and 400‐fold when complexed dimethyl β‐cyclodextrin (β‐CD) and hydroxypropyl‐β‐CD, respectively.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hydroxypropylation and Beta‐Amylase Treatment on Complexation of Debranched Starch With Naringenin

González¹,

Wang²,

Staroszczyk

et al. 2018

Starch Stärke

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Naringenin exhibits many health benefits but it has limited water solubility and consequently low bioavailability. The objective of this study is to investigate the effect of hydroxypropylation and enzymatic treatments on starch complexation with naringenin. Potato starch and Hylon VII are hydroxypropylated to two substitution degrees and then debranched or debranched/β‐amylase treated prior to complexing with naringenin. Both soluble and insoluble complexes are recovered and characterized. An increase in hydroxypropylation level improves recovery of soluble complexes, while total recovery remains unchanged; the β‐amylase treatment further increases soluble complex recovery. For the same treatment, the naringenin content is greater in Hylon VII complexes (6.72–15.15 mg g−1) than in potato starch complexes (2.45–11.18 mg g−1). Insoluble complexes have greater naringenin contents (3.91–15.15 mg g−1) compared to their soluble counterparts (2.45–9.43 mg g−1). All complexes exhibit a mixture of B + V X‐ray diffraction pattern. This work is the first one to demonstrate that hydroxypropylated starch forms complexes with naringenin, and an appropriate level of beta‐amylase hydrolysis further improves their complexation.

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Section: Introductionmentioning

confidence: 99%

Effect of Hydroxypropylation and Beta‐Amylase Treatment on Complexation of Debranched Starch With Naringenin

González¹,

Wang²,

Staroszczyk

et al. 2018

Starch Stärke

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“…Both of these flavanones have been reported to increase HDL cholesterol concentrations in some (104,105) but not all (106, 107) animal studies. However, little research has been done to evaluate the effect of dietary flavanones on HDL function.…”

Section: Flavanonesmentioning

confidence: 99%

Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL function

Millar

Duclos

Blesso

2017

Advances in Nutrition

153

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Strong experimental evidence confirms that HDL directly alleviates atherosclerosis. HDL particles display diverse atheroprotective functions in reverse cholesterol transport (RCT), antioxidant, anti-inflammatory, and antiapoptotic processes. In certain inflammatory disease states, however, HDL particles may become dysfunctional and proatherogenic. Flavonoids show the potential to improve HDL function through their welldocumented effects on cellular antioxidant status and inflammation. The aim of this review is to summarize the basic science and clinical research examining the effects of dietary flavonoids on RCT and HDL function. Based on preclinical studies that used cell culture and rodent models, it appears that many flavonoids (e.g., anthocyanidins, flavonols, and flavone subclasses) influence RCT and HDL function beyond simple HDL cholesterol concentration by regulating cellular cholesterol efflux from macrophages and hepatic paraoxonase 1 expression and activity. In clinical studies, dietary anthocyanin intake is associated with beneficial changes in serum biomarkers related to HDL function in a variety of human populations (e.g., in those who are hyperlipidemic, hypertensive, or diabetic), including increased HDL cholesterol concentration, as well as HDL antioxidant and cholesterol efflux capacities. However, clinical research on HDL functionality is lacking for some flavonoid subclasses (e.g., flavanols, flavones, flavanones, and isoflavones). Although there has been a tremendous effort to develop HDL-targeted drug therapies, more research is warranted on how the intake of foods or specific nutrients affects HDL function. Adv Nutr 2017;8:226-39.

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“…Increases in plasma and tissue cholesterol levels of ethanol-fed rats have been attributed to upregulation of HMG CoA reductase, the ratelimiting enzyme in the biosynthetic pathway of cholesterol [23]. Studies have demonstrated the inhibitory effect of NGM (50mg/kg) administered along with ethanol, on the activity of HMG CoA reductase [24].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the diuretic potentials of naringenin in hypercholesterolemic rats

Ansari¹,

Ganaie²,

Khan³

et al. 2018

Trop. J. Pharm Res

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Purpose:To investigate the diuretic potentials of naringenin (NGN) in obesity induced in rats by high fat diet (HFD). Methods: To prepare HFD, normal pellet diet was crushed and thoroughly mixed with cholesterol powder (1 % w/w). The mixture was mixed with some water and made into pellets which were then oven-baked to dry. Four groups of male Wistar albino rats (n = 6) were used for the study. Normal control (group I) received normal pellet diet. Group 2 (HFD-only) was fed HFD for 28 days, while Groups 3 and 4 were co-administered HFD and NGN at doses of 50 and 100 mg/kg, respectively. All treatments were given orally, and lasted for 28 days. Twenty-four hours after the last dose of NGN, blood was collected from all rats and total cholesterol levels determined to confirm obesity. Thereafter, the rats were placed in metabolic cages and urine samples were collected at two time-points (5 and 24 h) for measurement of urine volume, urinary pH, conductivity and electrolyte levels (Na, K and Cl). Results: Treatment with HFD resulted in significantly (p < 0.05) increased serum cholesterol level (178.83 ± 5.43 mg/dL) when compared to normal control rats (88.17 ± 4.04 mg/dL). It also led to decrease in urinary volume (~50 %) at both time points (5 and 24 h) and in excretion of urinary electrolytes (sodium, potassium and chloride ions). However, the changes in these parameters were significantly reversed by NGN administration (p < 0.05). Conclusion: These results demonstrate the diuretic activity of NGN in HFD-induced obese rats. Thus, NGN can be further explored for use in combination with hypolipidemic agents to tackle obesity. This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest

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Effect of Naringenin (Citrus Flavanone) on Lipid Profile in Ethanol-Induced Toxicity in Rats

Cited by 35 publications

References 46 publications

Effect of Hydroxypropylation and Beta‐Amylase Treatment on Complexation of Debranched Starch With Naringenin

Effect of Hydroxypropylation and Beta‐Amylase Treatment on Complexation of Debranched Starch With Naringenin

Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL function

Evaluation of the diuretic potentials of naringenin in hypercholesterolemic rats

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