Effect of 3-amino benzamide, a poly(adenosine diphosphate-ribose) polymerase inhibitor, in experimental caustic esophageal burn

Mercaptoethylguanidine attenuates caustic esophageal injury in rats: a role for scavenging of peroxynitrite

“…Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are believed to have a significant role in the postischemic tissue damage that cause cellular injury and subsequent necrosis via different mechanisms. As seen in thermal injuries of the skin [18], free oxygen radicals play an important role in the acute stage of an esophageal burn [14][15][16]19], which correlated with our previous studies [13,20]. After the acute phase, scar formation begins when fibroblast proliferation replaces the submucosa and muscularis with commencement of stricture formation.…”

The efficacy of ozone therapy in experimental caustic esophageal burn

“…Furthermore, tissue MDA and PCC levels (indices of tissue damage) were found to be significantly increased in the untreated group and decreased in the treatment group. Several studies revealed that ROS are generated at the burn site immediately after injury and these radicals causes tissue injury [4,5,7,[29][30][31]. On the other hand, it is well documented that ozone stimulates the production of interferon and interleukins in the body, in addition to eliciting endogenous production of antioxidant enzymes [17,18].…”

Medical ozone therapy reduces shock wave therapy-induced renal injury

“…17,18 It was also demonstrated that ozone increases antioxidant enzyme activities such as glutathione peroxidase (GSHPx), SOD, and catalase (CAT), preparing the host to face physiopathological conditions mediated by ROS/ RNS. 16,19 Ameliorative effects of OT on oxidative and nitrosative stress have been reported in different experimental models such as renal ischemia/reperfusion injury, 20 necrotizing pancreatitis, 21 caustic esophageal burn, 22 and necrotizing enterocolitis 23 by our research group. Based on these data and observations, we designed this study to find out whether OT has an ameliorative effect on ESW-induced renal injury in an experimental model of rats.…”