Effect of 5‐hydroxytryptamine on gastrointestinal motility in conscious guinea‐pigs

Nakajima, Masami; Shiihara, Yasufumi; Shiba, Yoshihiro; Sano, Isamu; Sakai, Takafumi; Mizumoto, Akiyoshi

doi:10.1046/j.1365-2982.1997.d01-56.x

Cited by 22 publications

(17 citation statements)

References 17 publications

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“…To our knowledge, only a few studies have investigated the physiological and pharmacological characterization of GI motility in the stomach and small intestine in conscious guinea pigs (18); however, those of colonic motility have not been investigated. In the present study, we recorded colonic motility in conscious guinea pigs implanted with force transducers and examined the effects of 5-HT4-receptor agonists (mosapride and cisapride) on colonic motility.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Mosapride Citrate, a 5-HT4 Receptor Agonist, on Colonic Motility in Conscious Guinea Pigs

Inui

Yoshikawa

Nagai

et al. 2002

Japanese Journal of Pharmacology

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ABSTRACT-It is known that 5-HT4 receptors in the colon of guinea pigs show a distribution similar to that in humans. Thus, we examined the effects of mosapride citrate (mosapride) and cisapride, two 5-HT4-receptor agonists, on colonic motility in conscious guinea pigs implanted with force transducers. Mosapride and cisapride administered intragastrically at doses of 3 -30 mg /kg significantly enhanced the colonic motility. The enhancing effect of mosapride was antagonized by atropine or GR113808, a 5-HT 4 -receptor antagonist, but not by methysergide, a 5-HT 1 -and 5-HT 2 -receptor antagonist; ondansetron, a 5-HT 3 -receptor antagonist; or CP-99994, a tachykinin NK 1 -receptor antagonist. In vitro receptor autoradiography showed that mosapride and cisapride inhibit the specific binding of [125 I]-SB207710, a selective radioligand of 5-HT 4 receptors, in the colon of guinea pigs. These results suggest that mosapride enhances colonic motility through the 5-HT 4 -receptor activation in guinea pigs and may be useful for treating constipation in patients with colonic motility dysfunction.

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Section: Discussionmentioning

confidence: 99%

“…The dose of each antagonist used was chosen because the dose had been reported in previous studies (8,14,18,19) to be effective in antagonizing the listed receptors. In the in vivo study, mosapride, and cisapride were suspended in 0.5% tragacanth solution.…”

Section: Drugsmentioning

confidence: 99%

Effects of Mosapride Citrate, a 5-HT4 Receptor Agonist, on Colonic Motility in Conscious Guinea Pigs

Inui

Yoshikawa

Nagai

et al. 2002

Japanese Journal of Pharmacology

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“…5‐HT exerts a confounding range of effects in the gut, due largely to the presence of multiple receptor subtypes which are present on smooth muscle, enteric neurones and enterocytes [27,28]. Seven types of 5‐HT receptors are now identified and among these, 5‐HT 3 and 5‐HT 4 receptors are shown to play important roles in GI physiology, including motor and secretory function.…”

Section: ‐Ht In Gi Tractmentioning

confidence: 99%

Gut hormones: emerging role in immune activation and inflammation

Khan

Ghia

2010

Clinical and Experimental Immunology

162

149

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SummaryGut inflammation is characterized by mucosal recruitment of activated cells from both the innate and adaptive immune systems. In addition to immune cells, inflammation in the gut is associated with an alteration in enteric endocrine cells and various biologically active compounds produced by these cells. Although the change in enteric endocrine cells or their products is considered to be important in regulating gut physiology (motility and secretion), it is not clear whether the change plays any role in immune activation and in the regulation of gut inflammation. Due to the strategic location of enteric endocrine cells in gut mucosa, these gut hormones may play an important role in immune activation and promotion of inflammation in the gut. This review addresses the research on the interface between immune and endocrine systems in gastrointestinal (GI) pathophysiology, specifically in the context of two major products of enteric endocrine systems, namely serotonin (5-hydroxytryptamine: 5-HT) and chromogranins (Cgs), in relation to immune activation and generation of inflammation. The studies reviewed in this paper demonstrate that 5-HT activates the immune cells to produce proinflammatory mediators and by manipulating the 5-HT system it is possible to modulate gut inflammation. In the case of Cgs the scenario is more complex, as this hormone has been shown to play both proinflammatory and anti-inflammatory functions. It is also possible that interaction between 5-HT and Cgs may play a role in the modulation of immune and inflammatory responses. In addition to enhancing our understanding of immunoendocrine interaction in the gut, the data generated from the these studies may have implications in understanding the role of gut hormone in the pathogenesis of both GI and non-GI inflammatory diseases which may lead ultimately to improved therapeutic strategies in inflammatory disorders.

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“…Smooth-muscle cells express 5-HT 1 and 5-HT 2 effector serotonin receptors [7,9]. Intramural ganglionar neurons and enterochromaffine cells have surface 5-HT 3 and 5-HT 4 receptors.…”

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confidence: 99%