“…In this study, WEP and emodin significantly decreased the gross lesion scores and TNF-α production. We hypothesize that the effect of WEP on TNF-α and IL-1β may be mediated either by suppressing the activation of this pro-inflammatory mediator and its transcriptional regulator (Frongoza et al, 2004;El-Abhar et al, 2008), and/or by inhibiting its production from macrophages (Tripathi et al, 2007). To the best of our knowledge, this is the first study to report that emodin and WEP may influence the generation of TNF-α and IL-1β WEP and emodin significantly reduced the levels of MDA, AST, ALT, TNF-α, and IL-1β in rats treated with CCl 4 , suggesting that WEP and emodin may prevent liver damage.…”