Hepatoprotection of emodin andPolygonum multiflorumagainst CCl₄-induced liver injury

Pharmacokinetics and tissue distribution of resveratrol, emodin and their metabolites after intake of Polygonum cuspidatum in rats

“…However, the present study showing that neither the free forms nor the sulfates/glucuronides of resveratrol and emodin were detected in brain provided strong indication that resveratrol and emodin cannot exert neuroprotection activity in the central nerve system. On the other hand, emodin has been reported to possess in vivo hepatoprotective effects which could be attributed to the activity of free form emodin in the liver (Bhadauria, 2010;Lee et al, 2012;Zhan et al, 2000). We suggest that the in vitro bioactivity of emodin can predict the in vivo effect in liver rather than other organs, given that the effective concentration of emodin is achievable in liver.…”

Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: A review

“…Both Polygonum multiflorum and Polygonum multiflorum Praeparata extracts (water-extracted, 15 g/kg/day, p.o., for 8 days) can be used to treat the hepatic lipid accumulation caused by prednisone acetate-, carbon tetrachloride-or thioacetamide-induced liver damage in mice (Liu et al, 1992). Moreover, these extracts attenuated liver damage by reducing lipid peroxidation as well as by positively modulating inflammation (Lee et al, 2012).…”

Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds

“…Laboratory studies and clinical practice have demonstrated that PMT possesses various biological and therapeutic actions, including anti-tumor,[1617] antibacterial,[18] anti-inflammatory,[13] anti-oxidant,[192021] anti-HIV,[22] liver protection,[2324] nephroprotection,[25] antidiabetic,[1526] anti-alopecia,[2728] and anti-atherosclerotic activities. [2930] It has been also reported to exert preventive activity against neurodegenerative diseases,[3132333435] cardiovascular diseases and to reduce hyperlipidemia as well.…”