Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds

Bounda, Guy‐Armel; Yu, Feng

doi:10.4103/0974-8490.157957

Cited by 89 publications

(29 citation statements)

References 113 publications

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“…Radix Polygoni Multiflori (RPM, Heshouwu in Chinese), the tuberous roots of Polygonum multiflorum unb. (Polygonaceae), is one of the most popular traditional Chinese medicines (TCMs) and has been used to treat hyperlipidemia, coronary heart disease, neurosis, and other diseases commonly associated with aging in China and other Asian countries for many centuries [1][2][3]. Besides its medical uses, RPM has been made as tonic food and beverages and has become popular as a result of the growing interests of general population in phytonutrients and alternative medicines during the past decades.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study

Cheng

Yang

et al. 2020

International Journal of Analytical Chemistry

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Radix Polygoni Multiflori (RPM) has been widely used to treat various diseases in Asian countries for many centuries. Although, stilbenes and anthraquinones, two major components of RPM, show various bioactive effects, it has been speculated that the idiosyncratic hepatotoxicity induced by RPM may be related to these constituents. However, information on the pharmacokinetics of stilbenes and anthraquinones at a subtoxic dose of RPM is limited. A simple and sensitive UPLC-MS/MS bioanalytical method for the simultaneous determination of 13 ingredients of RPM, including chrysophanol, emodin, aloe-emodin, rhein, physcion, questin, citreorosein, questinol, 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside, torachrysone-8-O-glucoside, chrysophanol-8-O-β-D-glucoside, emodin-8-O-β-D-glucoside, and physcion-8-O-β-D-glucoside, in rat plasma was established. Acetonitrile was employed to precipitate the plasma with appropriate sensitivity and acceptable matrix effects. Chromatographic separation was performed using a waters HSS C18 column with a gradient elution using water and acetonitrile both containing 0.025% formic acid within a run time of 9 min. e constituents were detected in negative ionization mode using multiple reaction monitoring. e method was fully validated in terms of selectivity, linearity, accuracy, precision, recovery, matrix effects, and stability. e lower limit of quantitation of the analytes was 0.1-1 ng/mL. e intrabatch and interbatch accuracies were 87.1-109%, and the precision was within the acceptable limits. e method was applied to a pharmacokinetic study after oral administration of RPM extract to rats at a subtoxic dose of 36 g/kg.

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Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study

Cheng

Yang

et al. 2020

International Journal of Analytical Chemistry

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“…There are two forms of PM decoctions in the Chinese Pharmacopoeia (2015): Raw Radix P. multiflorum (RPM) and P. multiflorum Preparata (PMP). While RPM contributes to detoxification and bowel relaxation, PMP tonifies the liver and kidney, benefits essence of blood and black beard, and relieves hyperlipidemia, fatty liver, and osteoporosis (Xuan et al, 2007;Wang et al, 2014;Bounda and Feng, 2015). Several clinical studies have been conducted to evaluate the traditional therapeutic claims including antiinflammatory bioactivity, dyslipidemia, sleep disorders, neurodegenerative disease.…”

Section: Introductionmentioning

confidence: 99%

Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges

et al. 2019

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Polygonum multiflorum Thunb. (PM), called Heshouwu in China, is a popular Chinese medicine in clinical practice. Several clinical studies have been conducted to evaluate the traditional therapeutic claims and to study the potential therapeutic activity of PM in dyslipidemia and neurodegenerative diseases, highlighting available clinical evidence. In recent years, reports on clinical adverse reactions of Raw Radix P. multiflorum (RPM) and P. multiflorum Praeparata (PMP) have been on the increase, especially with respect to liver injury. Most liver injury cases had been assessed for causality using RUCAM (Roussel Uclaf Causality Assessment Method) in this paper. However, the components of PM responsible for the reported hepatotoxic effects have not yet been identified. Moreover, many of the reports are contradictory, while studies on the mechanism involved in PM-induced liver damage are not comprehensive. This study was aimed at reviewing the status of research on liver injury due to PM, including clinical characteristics, risk factors, material basis research and mechanism of action, with a view to understanding PM-induced hepatotoxicity, and taking reasonable and effective measures to prevent it. In short, quality control is still one of the major safety problems in TCM drug safety concerns. The model of safety monitoring and risk management of PM drugs is not yet developed. Indeed, the characteristics and risk factors associated with PM require both proper understanding and control of the risk by strengthening standardization of clinical applications, basic science research, quality control in manufacturing, active monitoring methodology and enhancement of international communication and cooperation. Measures should also be encouraged and implemented to promote healthy development of the TCM industry.

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“…P. multiflorum praeparata (PMP) is used more frequently in clinical practice mainly because of its tonic and anti-aging effects, whereas PM is commonly applied to resolve toxins, moisten the intestines and free stools (China Pharmacopoeia Committee, 2015 ). Modern pharmacological studies and clinical practice have indicated these two medicines have various biological activities, including anti-tumor, anti-oxidative, anti-bacterial, anti-hyperlipidemia, anti-atherosclerosis, immunomodulating and hepatoprotective effects (Bounda and Feng, 2015 ; Lin et al, 2015a ; Li et al, 2016a ). The chemical profiles demonstrate that stilbenes and anthraquinones are the major characteristic constituents, of which 2,3,5,4′-tetrahydroxystilbene-2- O -β-glucoside (TSG), emodin-8- O -β-D-glucoside (EMG), and physcion-8- O -β-D-glucoside (PG) are found to be dominant in PM, while PMP mainly contains TSG, emodin and physcion (Bounda and Feng, 2015 ; Lin et al, 2015a ; Li et al, 2016a ).…”

Section: Introductionmentioning

confidence: 99%

Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity

et al. 2018

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Polygonum multiflorum Thunb. and its processed products have been used in China for centuries due to their multiple beneficial effects to human body. Currently, liver injuries caused by taking P. multiflorum have been reported worldwide, but the potential toxic components and possible mechanism that caused hepatotoxicity remain unclear. It is worth noting that the processing procedure could significantly decrease the toxicity of raw P. multiflorum and the processed products of P. multiflorum are considered to be relatively safe. However, the processing mechanism is still ambiguous, and there is the lack of a scientific approach to control the quality of P. multiflorum praeparata. This study is the first review that summarizes the recently advances (from 2007 to 2017) in the chemical analysis of P. multiflorum, and provides comprehensive information on the quantitative and qualitative analysis of P. multiflorum as well as its related species. In addition, the processing mechanism and quality evaluation of processed P. multiflorum are discussed. Moreover, the toxicity of P. multiflorum is analyzed from the perspectives of exploration of the proposed toxic ingredients, metabolite identification, metabolomics studies, and exogenous contaminant determination. Furthermore, trends and perspectives for future research of this medicine are discussed.

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Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds

Cited by 89 publications

References 113 publications

Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study

Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study

Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges

Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity

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