Effect of 8-Day Fasting on Leukocytes Expression of Genes and Proteins Involved in Iron Metabolism in Healthy Men

Borkowska, Andzelika; Tomczyk, Maja; Żychowska, Małgorzata; Pilis, Wiesław; Zych, Michał; Antosiewicz, Jędrzej

doi:10.3390/ijms22063248

Cited by 4 publications

(7 citation statements)

References 52 publications

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“…Recent studies on fasting and exercise in healthy men have shown that fasting stimulates the expression of genes involved in iron acquisition and decreases the expression of genes involved with iron storage and export [ 80 ]. Intermittent fasting in soccer players might lead to a decrease in the Hb, ferritin, and transferrin levels; though the decrease was statistically significant, the mean values remained within the normal ranges [ 81 ].…”

Section: Other Considerationsmentioning

confidence: 99%

Anemia in Sports: A Narrative Review

Damian

Vulturar

et al. 2021

Life

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Recent years have brought about new understandings regarding the pathogenesis of anemia in sports. From hemodilution and redistribution considered to contribute to the so-called “sports anemia” to iron deficiency caused by increased demands, dietary restrictions, decreased absorption, increased losses, hemolysis, and sequestration, to genetic determinants of different types of anemia (some related to sport), the anemia in athletes deserves a careful and multifactorial approach. Dietary factors that reduce iron absorption (e.g., phytate, polyphenols) and that augment iron’s bioavailability (e.g., ascorbic acid) should be considered. Celiac disease, more prevalent in female athletes, may underlie an unexplained iron deficiency anemia. Iron loss during exercise occurs in several ways: sweating, hematuria, gastrointestinal bleeding, inflammation, and intravascular and extravascular hemolysis. From a practical point of view, assessing iron status, especially in the athletes at risk for iron deficiency (females, adolescents, in sports with dietary restrictions, etc.), may improve the iron balance and possibly the performance. Hemoglobin and serum ferritin are measures that are easily employable for the evaluation of patients’ iron status. Cutoff values should probably be further assessed with respect to the sex, age, and type of sport. A healthy gut microbiome influences the iron status. Athletes at risk of iron deficiency should perform non-weight-bearing, low-intensity sports to avoid inducing hemolysis.

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Section: Other Considerationsmentioning

confidence: 99%

Anemia in Sports: A Narrative Review

Damian

Vulturar

et al. 2021

Life

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“…However, it is worth mentioning that adaptive changes to prolonged exercise, especially on mRNA levels, are not well documented. Intracellular changes in blood cells among genes encoding PCBP1, PCBP2, FTL, and FTH lead to understanding changes in regulation of iron economy in white cells and could be independent of plasma indicators in healthy and ill people [8].…”

Section: Introductionmentioning

confidence: 99%

The Effect of a Six-Week Nordic Walking Training Cycle on Oxidative Damage of Macromolecules and Iron Metabolism in Older Patients with Multiple Myeloma in Remission—Randomized Clinical Trial

Czerwińska-Ledwig,

Jurczyszyn,

Piotrowska

et al. 2023

IJMS

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Multiple myeloma (MM) is an incurable hematologic malignancy originating from clonal plasma cell proliferation within the bone marrow, predominantly affecting older individuals. While anemia serves as a diagnostic criterion for MM, it often ameliorates upon achieving disease remission. Iron metabolism parameters have emerged as potential prognostic indicators in MM. Notably, physical exercise has been established to influence iron metabolism. This study aimed to assess alterations in serum iron, ferritin, and transferrin concentrations, as well as leukocyte gene expression, in MM patients undergoing a six-week cycle of Nordic walking training. Thirty patients divided into an exercise group (NW, n = 15, mean age 63.1 ± 8.4 years) and a control group (CG, n = 15, mean age: 63.5 ± 3.6 years) completed the study protocol. Blood samples were collected at baseline, after three and six weeks of training, and after nine weeks. Serum ferritin, transferrin, and iron concentrations were measured, along with the leukocyte expression of genes. Additionally, serum oxidative damage marker levels were determined. Following the Nordic walking training cycle, a declining trend in serum ferritin concentrations was observed. Intracellular mRNA levels of genes associated with iron metabolism were positively influenced by the training regimen, indicating the potential impact of this physical activity on gene expression and ferritin concentrations. Although positive trends were noted, extended training periods might be requisite for significant changes. To conclude, moderate-intensity exercise induces favorable shifts in the analyzed parameters among MM patients, potentially influencing disease progression. Consequently, Nordic walking training is a safe recommendation for MM patients, though sustained training beyond six weeks could be necessary for notable effects on iron metabolism factors.

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“…Iron is taken up as ferrous and deposited as iron hydroxide after oxidation. The ferritin light chain (FLC) plays a role in the delivery of iron to cells and mediates iron uptake in the developing renal tunicate cells [ 35 , 36 ]. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes.…”

Section: Discussionmentioning

confidence: 99%

Quercetin inhibits the progression of endometrial HEC-1-A cells by regulating ferroptosis—a preliminary study

Zhu

et al. 2022

Eur J Med Res

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Background Endometrial carcinoma (EC) is one of the most common female reproductive system tumors, which seriously threatens women's health. This preliminary study aimed to investigate the effects of quercetin on the EC cells and explore the potential mechanism. Methods In this study, the effects of quercetin on endometrial cancer HEC-1-A cells were studied by a series of cell biological methods, including CCK-8 detection of cell activity, Western blotting of ferroptosis-related proteins, apoptosis detection, reactive oxygen species (ROS) detection and other detections. Results Our results showed that quercetin inhibited the proliferation and migration of EC cells, induced cell apoptosis, and affected the cell cycle. Furthermore, the anti-tumor effect of quercetin was related to the induction of ferroptosis in the EC cells. Conclusions Our study shows quercetin may exert anti-tumor effects, which may be related to the regulation of ferroptosis. Our study provides evidence for the future treatment of EC with small molecule drugs.

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Effect of 8-Day Fasting on Leukocytes Expression of Genes and Proteins Involved in Iron Metabolism in Healthy Men

Cited by 4 publications

References 52 publications

Anemia in Sports: A Narrative Review

Anemia in Sports: A Narrative Review

The Effect of a Six-Week Nordic Walking Training Cycle on Oxidative Damage of Macromolecules and Iron Metabolism in Older Patients with Multiple Myeloma in Remission—Randomized Clinical Trial

Quercetin inhibits the progression of endometrial HEC-1-A cells by regulating ferroptosis—a preliminary study

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