Effect of a 12-month exercise intervention on leukocyte telomere length: Results from the ALPHA Trial

Friedenreich, Christine M.; Wang, Qinggang; Ting, Nicholas S. Y.; Brenner, Darren R.; Conroy, Shannon M.; McIntyre, John B.; Mickle, A.; Courneya, Kerry S.; Beattie, Tara L.

doi:10.1016/j.canep.2018.07.012

Cited by 21 publications

(32 citation statements)

References 54 publications

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“…The inclusion criteria for the participants assigned to the control group were the same as those above, except the individuals did not take part in the Geriatric Revitalization Program or any other type of physical exercise program or activity. Therefore, the participants in the control group were described as being “currently inactive”, which was defined as not participating in regular physical activity or exercise of moderate intensity (30 cumulative minutes per day) on more than three days of the week, or exercising < 90 min/week [ 19 , 20 ]. The fact that the sample consisted only of women makes it possible to control those symptoms associated with the acceleration of telomeric shortening (already mentioned in the introduction section) such as smoking and alcohol since, according to epidemiological studies, women over 65 years of age exhibit fewer bad lifestyle habits which could influence telomeric activity than men.…”

Section: Methodsmentioning

confidence: 99%

Effects of Physical Exercise on Cognition and Telomere Length in Healthy Older Women

et al. 2021

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Background: Physical exercise is an effective measure for preventing the onset of cognitive decline and has a direct influence on the aging process. The purpose of this study was to assess the effect of a 6-month physical exercise program on cognition and telomere length in adults over 65 years of age. Method: Seventy-four healthy women were separated into two groups: 41 were included in the intervention group (IG) (72.70 ± 4.127 years and 8.18 ± 1.551 years of education) and 33 in the control group (CG) (71.21 ± 4.127 years and 8.42 ± 2.562). The participants included within the IG carried out three sessions of physical exercise per week for six months. Cognitive function was assessed using the Mini-Mental State Examination (MMSE), the Stroop test and the Trail Making Test (TMT). Saliva samples were taken and analyzed and relative telomere length was calculated. Those conducting the analysis were blind to the group to which the participants had been assigned. Results: An improvement was observed in global cognitive function, in both attentional and executive functions, in the group of adults doing physical exercise as compared to the control group. Six months after the physical exercise program had finished, relative telomere length was found to have increased in the participants in the intervention group. Conclusion: Physical exercise programs can lead to an improvement in both cognitive functions and telomere length.

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Section: Methodsmentioning

confidence: 99%

Effects of Physical Exercise on Cognition and Telomere Length in Healthy Older Women

et al. 2021

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“…The studies were generally small and heterogeneous with respect to the age and health characteristics of the participants, as well as the duration of the interventions. The majority lasted for less than a year [62][63][64][65][66][67][68][69][70][71][72], while four trials were conducted for a year or more [73][74][75][76][77]. In all of them telomere length was determined in either leukocytes or PBMC before and after the intervention.…”

Section: Non-pharmacological Interventionsmentioning

confidence: 99%

“…More recently, in one RCT conducted with family caregivers, aerobic exercise training was shown to increase telomere length after six months, without causing changes in telomerase activity [67]. In contrast, in another RCT carried out with healthy sedentary postmenopausal women, twelve month of aerobic exercise showed no effect on telomere length [76]. Finally, a recent RCT in healthy sedentary participants compared the effects of three exercise training modalities on telomerase activity and telomere length in PBMCs [89].…”

Section: Exercise and Physical Activitymentioning

confidence: 99%

Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link?

Erusalimsky

2020

Free Radical Biology and Medicine

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…However, after premenopausal women exercised three times a week for 6 months, and menopausal women aged 50 to 60 years exercised five times a week for 12 months (supervised exercise, three times a week), no difference between the exercise group and the non-exercise group was reported. Thus, the correlation between exercise and TL differs among women depending on exercise training periods and menopause 108,109…”

Section: Physical Activity and Telomerementioning

confidence: 99%

How Does Obesity and Physical Activity Affect Aging?: Focused on Telomere as a Biomarker of Aging

Shin

2019

JOMES

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Obesity is known to continuously increase systemic inflammation and oxidative stress, leading to shorter telomere length. However, research regarding the correlation between physical activity, exercise, obesity, and telomere length is not consistent. Therefore, this review aims to summarize the effects of obesity, physical activity, and exercise on telomere length. Our search for effects of obesity, physical activity, and exercise, on telomeres was conducted using three computerized databases: Medline, PubMed, and EBSCO. Keywords in the search were “physical activity, exercise and obesity,” “physical activity, exercise and telomere,” and “obesity and telomere.” Improving chronic inflammation and oxidative stress levels can prevent telomere attrition due to obesity. In addition, differences in the anti-aging effects of physical activity and exercise are shown in the post-middle-age period, when telomere length changes, rather than in past exercise habits. Maintaining high cardiorespiratory fitness levels through regular exercise and physical activity in the post-middle-age period minimizes obesity-related diseases and helps maintain telomere length, which is an index of cell senescence.

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Effect of a 12-month exercise intervention on leukocyte telomere length: Results from the ALPHA Trial

Cited by 21 publications

References 54 publications

Effects of Physical Exercise on Cognition and Telomere Length in Healthy Older Women

Effects of Physical Exercise on Cognition and Telomere Length in Healthy Older Women

Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link?

How Does Obesity and Physical Activity Affect Aging?: Focused on Telomere as a Biomarker of Aging

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