Effect Of A Branched-chain Amino Acids Supplementation On Muscle Soreness During Intensive Training Program

Koba, Takashige; Hamada, Koichiro; Sakurai, Masaru; Matsumoto, Keitaro; Higuchi, Tomoko; Zhao, Mangen; Miyata, Hirofumi

doi:10.1249/00005768-200505001-00228

Cited by 2 publications

(10 citation statements)

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“…The present findings are inconsistent with the findings of Coombes and Koba et all studies (7,18,19). Koba and colleagues showed that taking 10 grams of BCAA supplementation compared with a placebo reduced serum CK and LDH activities (24).…”

Section: Discussioncontrasting

confidence: 99%

The Effects of Two Different Dosages of BCAA Supplementation on A Serum Indicators of Muscle Damage in Wrestlers

Amirsasan

Saeed

Sari-Sarraf

et al. 2011

International Journal of Wrestling Science

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Background and Aim: Few studies have been done to examine the effect of different dosages of branched-chain amino acid (BCAA) supplementation on muscle damage indices in wrestlers. The purpose of this research was to compare the effects of two dosages of BCAA on muscle damage indices after heavy resistance exercise in wrestlers. Methods: 29 young wrestlers were randomly selected and divided into three groups. All subjects participated in heavy weight resistance exercise (3 sets, 10 repetitions, 80% 1RM). The BCAA was given at doses of 210 and 450 mg•kg 1 -body weight for supplemental groups 1 and 2 respectively, 30 minutes before and after the exercise test and dextrin was given at a dose of 210 mg.kg 1 -body weight for the placebo group. To identify enzyme activity (IU/L), venous blood samples were obtained 30 min prior to exercise and at 24 and 48 hrs post exercise. Data were statistically analyzed using ANOVA with repeated measures and the Bonfferoni test (P≥ 0.05). Results: Based on this study results, creatine kinase (CK), lactate dehydrogenase (LDH), creatine kinase isoenzyme MB (CK MB ) activity were significantly increased (p<0.05 ( in all groups. CK, LDH, CK MB indices having the highest activity in the placebo group, but there were no significant differences between all groups. Conclusion: These results provide evidence that the use of two different dosages of BCAA did not decrease the muscle damage associated with heavy resistance exercise.

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Section: Discussioncontrasting

confidence: 99%

The Effects of Two Different Dosages of BCAA Supplementation on A Serum Indicators of Muscle Damage in Wrestlers

Amirsasan

Saeed

Sari-Sarraf

et al. 2011

International Journal of Wrestling Science

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“…The characteristics of the 18 studies included in this meta-analysis are presented in Table 2. The studies were published between 2005 [60] and 2018 [61,62]. The study design was a randomized controlled trial with a crossover design in six studies [47,[63][64][65][66][67] A total of 331 participants were included across all studies, with 199 participants ingesting a BCAA supplement, and 200 participants ingesting placebo.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The intensity of cycling exercises varied from 55% [64] to 70% VO 2 max [73]. Long-distance exercises [60,68] and rowing races [65] were also used as endurance-damaging protocols.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Muscle damage and soreness were measured using CK, LDH, and DOMS. Studies measured only CK [65,69], only DOMS [47,63,68,72], CK and LDH [46,66,70,73], CK and DOMS [62,67,71,74,75], or CK, LDH, and DOMS [60,61,64].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Additionally, healthy active participants and studies including endurance-damaging protocols were excluded [ 29 ]. Moreover, previous meta-analyses [ 27 , 28 , 30 , 31 ] were conducted by including protocols using BCAA supplementation combined with other ingredients such as protein [ 33 ], green tea [ 34 ], arginine [ 35 , 36 ] and vitamins (A, E, and B6) [ 37 ]. Therefore, the independent effect of BCAA supplementation is impossible to identify.…”

Section: Introductionmentioning

confidence: 99%

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Attenuating Muscle Damage Biomarkers and Muscle Soreness After an Exercise-Induced Muscle Damage with Branched-Chain Amino Acid (BCAA) Supplementation: A Systematic Review and Meta-analysis with Meta-regression

Salem,

Ben Maaoui,

Jahrami

et al. 2024

Sports Med - Open

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Background Branched-chain amino acid (BCAA) supplementation is one of the most popular strategies used by the general population and athletes to reduce muscle soreness and accelerate the recovery process of muscle damage biomarkers after an intense exercise or training session. Objectives This systematic review and meta-analysis investigated the effects of BCAA supplementation on muscle damage biomarkers and muscle soreness after exercise-induced muscle damage (EIMD). Methods The systematic literature search for randomized controlled trials was conducted using seven databases, up to September 13th, 2022. The eligibility criteria for selecting studies were as follows: studies performed on healthy active participants, using BCAA at least once, controlled with a placebo or control group, performing resistance or endurance exercises, and followed up at least once post-EIMD. The methodological quality of the studies was assessed using the “SIGN RCT checklist”. Random-effects meta-analyses were processed to compute the standardized mean difference (Hedges’ g). Meta-regression analyses were completed with daily and total dosage and supplementation as continuous moderator variables. Results Of the 18 studies included in this meta-analysis, 13 were of high quality and five were of acceptable quality. Our results revealed BCAA supplementation elicits a significant effect on reducing creatine kinase (CK) levels immediately (g = − 0.44; p = 0.006) and 72 h (g = − 0.99; p = 0.002), but not 24 h, 48 h, and 96 h post-EIMD. Additionally, a significant effect on delayed onset of muscle soreness (DOMS) was identified at 24 h (g = − 1.34; p < 0.001), 48 h (g = − 1.75; p < 0.001), 72 h (g = − 1.82; p < 0.001), and 96 h (g = − 0.82; p = 0.008), but not immediately post-EIMD. No significant effect was found on lactate dehydrogenase (LDH) levels at any time point. Meta-regression indicated higher daily and total dosages of BCAA, and longer supplementation periods were related to the largest beneficial effects on CK (total dosage and supplementation period) at 48 h, and on DOMS at 24 h (only daily dosage). Conclusion The overall effects of BCAA supplementation could be considered useful for lowering CK and DOMS after EIMD, but not LDH. The longer supplementation period prior to the EIMD could be more effective for CK and DOMS reduction.

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Effect Of A Branched-chain Amino Acids Supplementation On Muscle Soreness During Intensive Training Program

Cited by 2 publications

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The Effects of Two Different Dosages of BCAA Supplementation on A Serum Indicators of Muscle Damage in Wrestlers

The Effects of Two Different Dosages of BCAA Supplementation on A Serum Indicators of Muscle Damage in Wrestlers

Attenuating Muscle Damage Biomarkers and Muscle Soreness After an Exercise-Induced Muscle Damage with Branched-Chain Amino Acid (BCAA) Supplementation: A Systematic Review and Meta-analysis with Meta-regression

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