Effect of a cardiac rehabilitation program on left ventricular diastolic function and its relationship to exercise capacity in patients with coronary heart disease: Experience from a randomized, controlled study

Yu, Cheuk‐Man; Li, Leonard Sheung-Wai; Lam, Man-Fai; Siu, Deyond Y.W.; Miu, Raymond; Lau, Chu‐Pak

doi:10.1016/j.ahj.2003.12.004

Cited by 58 publications

(42 citation statements)

References 28 publications

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“…The role of aerobic exercise training on cardiac function is controversial (12,36). A previous training study in patients with coronary heart disease and preserved systolic function reported that exercise lessened the severity of diastolic dysfunction (37). In this study, we have shown that exercise may be effective through improvement in e'.…”

Section: Discussionsupporting

confidence: 50%

Effects of Exercise and Lifestyle Intervention on Cardiovascular Function in CKD

Howden

Leano

Petchey

et al. 2013

Clinical Journal of the American Society of Nephrology

118

131

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SummaryBackground and objectives CKD is associated with poor cardiorespiratory fitness (CRF). This predefined substudy determined the effect of exercise training and lifestyle intervention on CRF and explored the effect on cardiovascular risk factors and cardiac and vascular function. Results Ten percent of randomized patients had subclinical myocardial ischemia at screening and completed the study without incident. There was no baseline difference among 72 patients who completed follow-up (36 in the lifestyle intervention group and 36 in the control group). The intervention increased peak _ VO 2 (2.860.7 ml/kg per minute versus 20.360.9 ml/kg per minute; P=0.004). There was small weight loss (21.864.2 kg versus 0.763.7 kg; P=0.02) but no change in BP or lipids. Diastolic function improved (increased e' of 0.7561.16 cm/s versus 20.4761.0 cm/s; P=0.001) but systolic function was well preserved and did not change. The change in arterial elastance was attenuated (0.1160.76 mmHg/ml versus 0.7660.96 mmHg/ml; P=0.01). D peak _ VO 2 was associated with group allocation and improved body composition.Conclusions Exercise training and lifestyle intervention in patients with CKD produces improvements in CRF, body composition, and diastolic function.

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Section: Discussionsupporting

confidence: 50%

Effects of Exercise and Lifestyle Intervention on Cardiovascular Function in CKD

Howden

Leano

Petchey

et al. 2013

Clinical Journal of the American Society of Nephrology

118

131

View full text Add to dashboard Cite

show abstract

“…Patients after myocardial infarction and with preexistent abnormal relaxation patterns benefit from endurance training, as shown by Yu et al 81 Although data on training effects in patients with diabetes mellitus derived from small studies are still controversial, 82,83 data on patients with established heart failure with normal ejection fraction are convincingly positive. 84 CHF with systolic dysfunction is associated primarily with significant diastolic dysfunction.…”

Section: Curative Effectsmentioning

confidence: 81%

Cardiovascular Effects of Exercise Training

2010

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“…From January 1998 to December 2005, 617 consecutive patients who recently survived an ST-segment elevation MI (>40 days) were referred to the Cardiac Rehabilitation and Prevention Center of Tung Wah Hospital (18,19). This is the largest rehabilitation facility in Hong Kong and serves a population of about half a million.…”

Section: Methodsmentioning

confidence: 99%

Sudden Cardiac Death After Myocardial Infarction in Type 2 Diabetic Patients With No Residual Myocardial Ischemia

Yeung

Lam

et al. 2012

Diabetes Care

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OBJECTIVEDiabetes mellitus (DM) is a well-established risk factor for coronary artery disease. Nonetheless, it remains unclear whether DM contributes to sudden cardiac death in patients who survive myocardial infarction (MI). The objective of this study was to compare the incidence of sudden cardiac death post-MI in diabetic and nondiabetic patients with no residual myocardial ischemia.RESEARCH DESIGN AND METHODSA total of 610 consecutive post-MI patients referred to a cardiac rehabilitation program with negative exercise stress test were studied.RESULTSOf these, 236 patients had DM at baseline. Over a mean follow-up of 5 years, 67 patients with DM (28.4%) and 76 of 374 patients without DM (20.2%) had died with a hazard ratio (HR) of 1.74 (95% CI: 1.28–2.56; P < 0.001). Patients with DM also had a higher incidence of cardiac death (1.84 [1.16–3.21]; P = 0.01), principally due to a higher incidence of sudden cardiac death (2.14 [1.22–4.23]; P < 0.001). Multiple Cox regression analysis revealed that only DM (adjusted HR: 1.9 [95% CI: 1.04–3.40]; P = 0.04), left ventricular ejection fraction (LVEF) ≤30% (3.6 [1.46–8.75]; P < 0.01), and New York Heart Association functional class >II (4.2 [1.87–9.45]; P < 0.01) were independent predictors for sudden cardiac death. Among patients with DM, the 5-year sudden cardiac death rate did not differ significantly among those with LVEF ≤30%, LVEF 31–50%, or LVEF >50% (8.8 vs. 7.8 vs. 6.8%, respectively; P = 0.83).CONCLUSIONSPost-MI patients with DM, even in the absence of residual myocardial ischemia clinically, were at higher risk of sudden cardiac death than their non-DM counterparts.

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Effect of a cardiac rehabilitation program on left ventricular diastolic function and its relationship to exercise capacity in patients with coronary heart disease: Experience from a randomized, controlled study

Cited by 58 publications

References 28 publications

Effects of Exercise and Lifestyle Intervention on Cardiovascular Function in CKD

Effects of Exercise and Lifestyle Intervention on Cardiovascular Function in CKD

Cardiovascular Effects of Exercise Training

Sudden Cardiac Death After Myocardial Infarction in Type 2 Diabetic Patients With No Residual Myocardial Ischemia

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