Effect of a Cholinesterase Inhibitor Treatment on the Phosphorus and Nucleic Acid Metabolism in the Stomach Wall

Mózsik, Gy.; Kiss, Borbála; Jávor, T; Krausz, M.; Tóth, E.

doi:10.1159/000135998

Cited by 13 publications

(5 citation statements)

References 4 publications

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“…In the indomethacin‐treated ulcer group, A. racemosus treatment showed a significant increase in the TC/TP ratio, but in the stress‐treated group the decrease in ratio was significant in the W. somnifera ‐treated group. Total carbohydrate is indicative of the mucus‐secreting index, and TC/TP is taken as a reliable marker for mucin secretion,47,48 which makes a protective layer over the stomach wall.…”

Section: Discussionmentioning

confidence: 99%

Antiulcer and Antioxidant Activity of Asparagus racemosus WILLD and Withania somnifera DUNAL in Rats

Bhatnagar

Sisodia

Bhatnagar

2005

Annals of the New York Academy of Sciences

108

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Comparative study of the antiulcer and antisecretory activity of Asparagus racemosus Willd (Shatawari) and Withania somnifera Dunal (Ashwagandha) root extract with a standard drug, ranitidine, in various models of gastric ulcer in rats is presented. Ulcer was induced by the indomethacin (NSAID) and swim (restraint) stress treatment. Results demonstrated that A. racemosus as well as W. somnifera methanolic extract (100 mg/kg BW/day p.o.) given orally for 15 days significantly reduced the ulcer index, volume of gastric secretion, free acidity, and total acidity. A significant increase in the total carbohydrate and total carbohydrate/protein ratio was also observed. Study also indicated an increase in antioxidant defense, that is, enzymes superoxide dismutase, catalase, and ascorbic acid, increased significantly, whereas a significant decrease in lipid peroxidation was observed. A. racemosus was more effective in reducing gastric ulcer in indomethacin-treated gastric ulcerative rats, whereas W. somnifera was effective in stress-induced gastric ulcer. Results obtained for both herbal drugs were comparable to those of the standard drug ranitidine.

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Section: Discussionmentioning

confidence: 99%

Antiulcer and Antioxidant Activity of Asparagus racemosus WILLD and Withania somnifera DUNAL in Rats

Bhatnagar

Sisodia

Bhatnagar

2005

Annals of the New York Academy of Sciences

108

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“…In addition to gastric acid secretion, reflex or neurogenic effects have also been suggested as playing an important role in the formation of gastric ulcers in the pylorus ligation model (Anichkov et al, 1971). Increased synthesis of nucleic acids and increased metabolism of carbohydrates and thereby exhaustion of carbohydrates and other compensatory mechanisms could be responsible for ulceration due to pylorus ligation (Mozsik et al, 1969). Moreover, one of the essential criteria to determine the status of mucus resistance/barrier is the state of mucus secretion.…”

Section: Discussionmentioning

confidence: 99%

Study of Mimusops elengi bark in experimental gastric ulcers

Shah

Gandhi

Shah³

et al. 2003

Journal of Ethnopharmacology

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“…Gastric hypersecretion plays an important role in production of experimental ulcers by pylorus ligation (Kitagawa et al, 1978). Increased biosynthesis of nucleic acids and increased metabolism of carbohydrates and thereby exhaustion of carbohydrates and other compensatory mechanisms could also be responsible for ulceration due to pylorus ligation (Mozsik et al, 1969). The essential criteria, which determine the status of mucosal defense barrier against the offensive assault of acid-pepsin is the quality and quantity of gastric mucus secretion (Sanyal et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

Antiulcer activity of Trichosanthes cucumerina linn. against experimental gastro-duodenal ulcers in rats

Galani¹,

Goswami²,

Shah³

2010

Oriental Pharmacy and Experimental Medicine

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SUMMARYTrichosanthes cucumerina Linn. (cucurbitaceae) is widely used in Indian folk medicine for variety of disease conditions. The aim of present study was to evaluate the antiulcer activity of 50% ethanolic extract of fruits of Trichosanthes cucumerina Linn. (TCFE) using various experimental models of gastric and duodenal ulceration in rats. Oral administration of 50% ethanolic extract of fruits of Trichosanthes cucumerina Linn. was evaluated in rats against ethanol, aspirin and pylorus ligated gastric ulcers as well as cysteamine-induced duodenal ulcers. In all the models studied, the antiulcer activity of TCFE compared with that of cimetidine (100 mg/kg, p.o.), an H 2 receptor antagonist. TCFE showed significant antiulcer activity in ethanol-induced and aspirin-induced gastric ulcer models. In 19 h pylorus ligated rats, significant reduction in ulcer index, total acidity and pepsin activity was observed with TCFE, when compared with the control group. Mucosal defensive factors such as pH, mucin activity and gastric wall mucous content was found to be increased with TCFE. TCFE was also, afforded remarkable protection in cysteamine-induced duodenal lesions. The antiulcer activity of TCFE was comparable with that of cimetidine. Thus, TCFE possess significant antiulcer activity against both gastric and duodenal ulcers in rats. The antiulcer activity may be attributed to its cytoprotective action and inhibition of acid secretary parameters.

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Effect of a Cholinesterase Inhibitor Treatment on the Phosphorus and Nucleic Acid Metabolism in the Stomach Wall

Cited by 13 publications

References 4 publications

Antiulcer and Antioxidant Activity of Asparagus racemosus WILLD and Withania somnifera DUNAL in Rats

Antiulcer and Antioxidant Activity of Asparagus racemosus WILLD and Withania somnifera DUNAL in Rats

Study of Mimusops elengi bark in experimental gastric ulcers

Antiulcer activity of Trichosanthes cucumerina linn. against experimental gastro-duodenal ulcers in rats

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