Effect of a combination of inulin and polyphenol-containing adzuki bean extract on intestinal fermentation in vitro and in vivo

Nagata, Ryuji; Echizen, Mao; Yamaguchi, Yukari; Han, Kyu‐Ho; Shimada, Kaoru; Ohba, Kohtaro; Kitano-Okada, Tomoko; Nagura, Taizo; Uchino, H.; Fukushima, Michihiro

doi:10.1080/09168451.2018.1429886

Cited by 24 publications

(8 citation statements)

References 44 publications

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“…After a 7 d acclimation period, the rats were randomly assigned to four groups and fed one of the experimental diets (Oriental Yeast Co., Ltd., Tokyo, Japan) formulated based on the AIN-93G diet (Table 1) for 4 wk. Care and dissection of the rats were conducted as previously described (17).…”

Section: Methodsmentioning

confidence: 99%

Effects of Raw Potato Starch with High Resistant Starch Levels on Cecal Fermentation Properties in Rats

Nagata

Innami

Pelpolage

et al. 2019

J Nutr Sci Vitaminol

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The effects of potato starch, isolated from Snowden (SD) and Kitahime (KH) varieties, on cecal fermatation properties in rats were evaluated. In high-amylose cornstarch (HAS), SD and KH groups, cecal acetate and total short-chain fatty acid concentrations were increased and cecal pH was lowered compared to control (CON) group. Further, cecal immunoglobulin A levels were increased and cecal ammonia-nitrogen, p-cresol, skatole and indole concentrations were lowered in HAS, SD and KH groups compared to the CON group. Therefore, potato starch might possess beneficial intestinal fermentation properties.

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Section: Methodsmentioning

confidence: 99%

Effects of Raw Potato Starch with High Resistant Starch Levels on Cecal Fermentation Properties in Rats

Nagata

Innami

Pelpolage

et al. 2019

J Nutr Sci Vitaminol

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“…Ammonia-nitrogen (AN), Immunoglobulin A (IgA) in cecal digesta and serum (fasting) biochemical analysis. AN and IgA in the diluted samples of cecal content and the serum biochemical parameters were analyzed according to the procedures reported in (6).…”

Section: Methodsmentioning

confidence: 99%

In Vivo Colonic Fermentation of Sorghum (Sorghum bicolor L.): Important Correlations Observed among the Physiological Parameters of Cecum, Liver, Adipose Tissue and Fasting Serum Lipid Profile

Pelpolage

Nagata

Fukuma

et al. 2019

J Nutr Sci Vitaminol

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High amylose corn starch (HAS), whole grain sorghum (S-Wh), refined sorghum (S-Rf) and acorn starch (CON) diets were fed to animals for 1 mo aiming to examine the physiological effects of resistant starch inclusion in the diet from grains. HAS exhibited significantly lower feed intake, final body weight, serum lipid profile with significantly higher cecal parameters and short chain fatty acid (SCFA) contents. S-Wh group exhibited significantly higher body weight, feed intake and serum lipid parameters compared to other 3 groups. Cecal fermentation was not seemed to be prominent in the CON, S-Wh and S-Rf groups with respect to lower cecal parameters and SCFA contents. The cecal microbial compositions in HAS, S-Wh and CON/S-Rf exhibited 3 distinct clusters suggesting a significant effect of the cecal microbial composition on cecal parameters, SCFA contents and physiological parameters. .

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“…Butyrate is a major fuel source for ileal and colonic enterocytes (14,15). Rodent and clinical studies have shown metabolic improvements after supplementation with fibers and/or polyphenols (13,(16)(17)(18)(19) or pure SCFAs (20)(21)(22). Counterintuitively, higher SCFA Abbreviations: EE, Energy expenditure; GP, grape polyphenol; HFD, high fat diet; HFHS, high fat high sucrose; LFD, low fat diet; NAFLD, non-alcoholic fatty liver disease; OGT(T), oral glucose tolerance (test); PAC, proanthocyanidin; SCFA, short chain fatty acid; WD, Western diet; WD-GP, Western diet with grape polyphenols.…”

Section: Introductionmentioning

confidence: 99%

Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis in Mice in Association With Reduced Butyrate and Increased Markers of Intestinal Carbohydrate Oxidation

Mezhibovsky

Knowles

et al. 2021

Front. Nutr.

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A Western Diet (WD) low in fiber but high in fats and sugars contributes to obesity and non-alcoholic fatty liver disease (NAFLD). Supplementation with grape polyphenols (GPs) rich in B-type proanthocyanidins (PACs) can attenuate symptoms of cardiometabolic disease and alter the gut microbiota and its metabolites. We hypothesized that GP-mediated metabolic improvements would correlate with altered microbial metabolites such as short chain fatty acids (SCFAs). To more closely mimic a WD, C57BL/6J male mice were fed a low-fiber diet high in sucrose and butterfat along with 20% sucrose water to represent sugary beverages. This WD was supplemented with 1% GPs (WD-GP) to investigate the impact of GPs on energy balance, SCFA profile, and intestinal metabolism. Compared to WD-fed mice, the WD-GP group had higher lean mass along with lower fat mass, body weight, and hepatic steatosis despite consuming more calories from sucrose water. Indirect and direct calorimetry revealed that reduced adiposity in GP-supplemented mice was likely due to their greater energy expenditure, which resulted in lower energy efficiency compared to WD-fed mice. GP-supplemented mice had higher abundance of Akkermansia muciniphila, a gut microbe reported to increase energy expenditure. Short chain fatty acid measurements in colon content revealed that GP-supplemented mice had lower concentrations of butyrate, a major energy substrate of the distal intestine, and reduced valerate, a putrefactive SCFA. GP-supplementation also resulted in a lower acetate:propionate ratio suggesting reduced hepatic lipogenesis. Considering the higher sucrose consumption and reduced butyrate levels in GP-supplemented mice, we hypothesized that enterocytes would metabolize glucose and fructose as a replacement energy source. Ileal mRNA levels of glucose transporter-2 (GLUT2, SLC2A2) were increased indicating higher glucose and fructose uptake. Expression of ketohexokinase (KHK) was increased in ileum tissue suggesting increased fructolysis. A GP-induced increase in intestinal carbohydrate oxidation was supported by: (1) increased gene expression of duodenal pyruvate dehydrogenase (PDH), (2) a decreased ratio of lactate dehydrogenase a (LDHa): LDHb in jejunum and colon tissues, and (3) decreased duodenal and colonic lactate concentrations. These data indicate that GPs protect against WD-induced obesity and hepatic steatosis by diminishing portal delivery of lipogenic butyrate and sugars due to their increased intestinal utilization.

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Effect of a combination of inulin and polyphenol-containing adzuki bean extract on intestinal fermentation in vitro and in vivo

Cited by 24 publications

References 44 publications

Effects of Raw Potato Starch with High Resistant Starch Levels on Cecal Fermentation Properties in Rats

Effects of Raw Potato Starch with High Resistant Starch Levels on Cecal Fermentation Properties in Rats

In Vivo Colonic Fermentation of Sorghum (<i>Sorghum bicolor</i> L.): Important Correlations Observed among the Physiological Parameters of Cecum, Liver, Adipose Tissue and Fasting Serum Lipid Profile

Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis in Mice in Association With Reduced Butyrate and Increased Markers of Intestinal Carbohydrate Oxidation

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