Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo

The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH

“…Our results essentially confirmed the previous observation of Roy et al [32], that algae extract inhibits the in vitro activity of the two enzymes in a dose-dependent manner. In particular, Figure 1 shows that the complete inhibition of α-amylase and α-glucosidase activities can be reached at an algae extract concentration of 30 μg/mL and 2 μg/mL, respectively.…”

“…The ability of a phytocomplex obtained from these algae to inhibit both enzymes has already been demonstrated by Roy et al [32], and was confirmed in this research. In particular, the IC 50 value of this extract for α-amylase inhibition was 10 to 1000-fold lower than that reported for algae extracts prepared with solvents [17], fruit extracts [38], or polyphenols obtained from other plants [39,40].…”

Ascophyllum nodosum and Fucus vesiculosus on glycemic status and on endothelial damage markers in dysglicemic patients

“…The positive results on glycemic control observed in our study can be due to the inhibiting action of the polyphenolic composition (extracted from A. nodosum and F. vesiculosus) towards enzymatic activities, in an acarbose-like mechanism. The ability of a phytocomplex obtained from these algae to inhibit both enzymes has already been demonstrated by Roy et al (2011) and confirmed by Gabbia et al (2017) who showed that the administration of the extract in a diet particularly rich in fat in mice is associated with a delay in carbohydrate digestion but also with a decrease in its assimilation. Reducing PPG with the nutraceutical, probably, leads to a minor work for the β-cells and a consequent longer preservation of β-cell function.…”

Aqueous extracts and suspensions of restructured pork formulated with Undaria pinnatifida, Himanthalia elongata and Porphyra umbilicalis distinctly affect the in vitro α-glucosidase activity and glucose diffusion

“…Cho et al (2011) reported that sulphated fucoidans of Wakame exhibit a non-competitive inhibition mechanism, partially explaining that the mainly bioactive compound in relation with this activity in SRP is not the soluble fibre. On the other hand, Roy et al (2011) found in their in vitro test that the phlorotannins extracts completely inhibited a-glucosidase in a dose-dependent manner. Moreover, Moon et al (2011) showed as Eckol and Dieckol phlorotannins exerted a strong a-glucosidase inhibitory effect through a non-competitive mechanism.…”