Effect of a High-sucrose Diet on Abdominal Aortic Aneurysm Development in a Hypoperfusion-induced Animal Model

Miyamoto, Chie; Kugo, Hirona; Hashimoto, Keisuke; Sawaragi, Ayaka; Zaima, Nobuhiro; Moriyama, Tatsuya

doi:10.5650/jos.ess17264

Cited by 12 publications

(4 citation statements)

References 18 publications

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“…Abdominal aortic aneurysm AAA is an inflammatory cardiovascular disease common among the elderly 1,2 , and whose pathogenesis is not fully understood 1,3 . Surgical repair is currently the only option for preventing AAA rupture 4 and, notably, endovascular treatment improves the surgical outcome in AAA treatment 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Proprotein Convertase Subtilisin/Kexin Type 9 Is Associated with Degenerating Adipocytes in Abdominal Aortic Aneurysm

et al. 2018

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Abdominal aortic aneurysm (AAA) is a common disease among the elderly. Recently, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been indicated as useful therapeutic tools for the treatment of cardiovascular diseases. The aim of this study was to elucidate the role of PCSK9 in the pathogenesis of AAA. We used fluorescence immunohistochemistry to assess the expression of PCSK9 in aortic tissues resected from 24 patients with AAA. Histological examination showed that PCSK9 expression in the adventitia region of the aneurysms was decreased in AAA samples. In the same region, the expression of CD36 increased. We hypothesized that CD36 expression might upregulate the transport of fatty acids into cells such as the adipocytes, and subsequently cause degradation of the adventitia in the aortic wall, contributing to AAA development.

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Section: Introductionmentioning

confidence: 99%

Proprotein Convertase Subtilisin/Kexin Type 9 Is Associated with Degenerating Adipocytes in Abdominal Aortic Aneurysm

et al. 2018

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“…HF diets have been reported to increase the risk of abdominal aortic aneurysm (AAA) development [14,25,42,43]. In contrast, the HS diet does not affect the risk of development and rupture of AAA [26]. Previous studies have suggested a relationship between the dysfunction of PVAT and AAA [44][45][46][47].…”

Section: Discussionmentioning

confidence: 99%

“…Since dietary fats and sucrose are converted to triglycerides, fat-or sucrose-rich diets can cause hypertrophy of adipocytes, resulting in adipose tissue inflammation [23]. Excessive intake of fat and sucrose has been shown to have different effects on the pathology of vascular and metabolic diseases [24][25][26][27]. However, the effects of high-fat (HF) and highsucrose (HS) diets on PVAT remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Different effects of high-fat and high-sucrose diets on the physiology of perivascular adipose tissues of the thoracic and abdominal aorta

et al. 2021

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Vascular diseases such as atherosclerosis and aneurysms are associated with diet. Perivascular adipose tissue (PVAT) was reportedly involved in the regulation of vascular functions. It is suggested that imbalanced diets can cause PVAT inflammation and dysfunction as well as impaired vascular function. However, the association between diets and PVAT are not clearly understood. Here, we showed that a high-fat and a high-sucrose diet affected PVAT at different sites. A high-fat diet induced increased number of large-sized lipid droplets and increased CD (Cluster of differentiation) 68+ macrophage- and monocyte chemotactic protein (MCP)-1-positive areas in the abdominal aortic PVAT (aPVAT). In addition, a high-fat diet caused decreased collagen fibre-positive area and increased CD68+ macrophage- and MCP-1-positive areas in the abdominal aorta. In contrast, a high-sucrose diet induced increased number of large-sized lipid droplets, increased CD68+ macrophage- and MCP-1-positive areas, and decreased UCP-1 positive area in the thoracic aortic PVAT (tPVAT). A high-sucrose diet caused decreased collagen fibre-positive area and increased CD68+ macrophage- and MCP-1-positive areas in the thoracic aorta. These results could be attributed to the different adipocyte populations in the tPVAT and aPVAT. Our results provide pathological evidence to improve our understanding of the relationship between diet and vascular diseases.

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“…The denatured collagen was measured by using collagen hybridizing peptide (3Helix, Utah, USA) Quantitative analysis of the histological staining was performed using ImageJ software (National Institutes of Health, Bethesda, MD, USA). Areas within 100 µm of an adipocyte were defined as “areas with adipocytes.” Elastic fibers were categorized into 4 grades: grade 1, intact elastic fibers; grade 2, lack of wave form; grade 3, thinning of the wave form and/or partial disappearance of elastic fibers; and grade 4, complete disappearance of elastic fibers 17,35 . Immunohistochemical staining were performed as previously described 35 .…”

Section: Methodsmentioning

confidence: 99%

Ovariectomy increases the incidence and diameter of abdominal aortic aneurysm in a hypoperfusion-induced abdominal aortic aneurysm animal model

Miyamoto

Kugo

Hashimoto

et al. 2019

Sci Rep

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Abdominal aortic aneurysm (AAA) is a vascular disease characterized by weakening of the vascular walls. Male sex is a risk factor for AAA, and peak AAA incidence occurs in men 10 years earlier than in women. However, the growth rate of AAA is faster in women, and women have a higher mortality due to AAA rupture. The mechanisms underlying sex-related differences in AAA remain unknown. Herein, we evaluated the effects of ovariectomy (OVX) on AAA in rats. Upon evaluation of the effects of OVX and AAA induction, AAA incidence rate and the aneurysm diameter increased in the OVX group. However, the histopathology in the developed AAA wall was not different between groups. When the effects of OVX on the vascular wall without AAA induction were evaluated, elastin and collagen levels were significantly decreased. Furthermore, the level of matrix metalloproteinase-9 significantly increased in the OVX group. According to our results, it is speculated that decreased levels of collagen and elastin fibers induced by OVX might be involved in increased incidence rate and diameter of AAA. Weakening of the vascular wall before the onset of AAA might be one reason for the faster rate of AAA growth in women.

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Effect of a High-sucrose Diet on Abdominal Aortic Aneurysm Development in a Hypoperfusion-induced Animal Model

Cited by 12 publications

References 18 publications

Proprotein Convertase Subtilisin/Kexin Type 9 Is Associated with Degenerating Adipocytes in Abdominal Aortic Aneurysm

Proprotein Convertase Subtilisin/Kexin Type 9 Is Associated with Degenerating Adipocytes in Abdominal Aortic Aneurysm

Different effects of high-fat and high-sucrose diets on the physiology of perivascular adipose tissues of the thoracic and abdominal aorta

Ovariectomy increases the incidence and diameter of abdominal aortic aneurysm in a hypoperfusion-induced abdominal aortic aneurysm animal model

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