Effect of a hypocaloric diet in the oxidative stress in obese subjects without prescription of exercise and antioxidants

Gutiérrez-Carrasquilla, Liliana; García, J.R.; Rincón, María de Jesús; Ceballos, Guillermo; Olivares, Ivonne

doi:10.1016/j.medcle.2015.12.043

Cited by 5 publications

(8 citation statements)

References 25 publications

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“…A different study showed that 9.4% of the weight loss due to dietary and healthy lifestyle modifications was associated with reduced plasma levels of leptin and hs-CRP and improved insulin resistance and lipid profiles 17. All of these changes in the parameters and inflammatory profile indicate that weight loss facilitates amelioration of the inflammatory status 18. A study that followed severely obese patients during a 15-week hypocaloric diet and daily moderate activity found that hs-CRP decreased and adiponectin increased significantly, indicating that a minimum of 10% of weight loss is necessary to improve the pro-inflammatory parameters in people with obesity 3.…”

Section: Discussionmentioning

confidence: 99%

Does weight loss affect the parameters that are metabolically related to cardiovascular diseases?

Özkan

Yiğit²,

Yiğit³

2019

SMJ

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Objectives: To assess the differences in the parameters that are metabolically related to cardiovascular diseases after weight loss in obese people with coronary artery diseases (CADs). Methods: This study was conducted on 184 patients who were diagnosed with CADs in Istanbul University Cardiology Institute Hospital, Istanbul, Turkey. The levels of leptin, fibrinogen, homocysteine, high-sensitivity C-reactive protein (hs-CRP), triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), fasting blood glucose and insulin, glycated hemoglobin, and uric acid of the obese patients who were put on calorie restricted diet were evaluated retrospectively and compared before and after weight loss. For comparison, non-obese control patients were also studied. Student’s t-test and Chi-square test were used for the statistical analysis. Results: Levels of homocysteine, glycated hemoglobin, and leptin were significantly higher in the obese patients than in the non-obese patients. Diabetic obese patients with CADs lost (11.1%) and non-diabetic obese patients with CADs lost (10.5%) of their body weight in 6 months. The levels of cholesterol, LDL-C, and fibrinogen were significantly improved in both groups. Conclusion: The obese patients lost weight after being on calorie-restricted diets and showed significant improvement in the levels of cholesterol, LDL-C, fibrinogen. There was no significant difference in the levels of homocysteine, hs-CRP, and leptin before and after weight loss in both diabetic and non-diabetic obese patients.

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Section: Discussionmentioning

confidence: 99%

Does weight loss affect the parameters that are metabolically related to cardiovascular diseases?

Özkan

Yiğit²,

Yiğit³

2019

SMJ

View full text Add to dashboard Cite

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“…Additionally, it must be considered that ROS vary greatly depending on many factors. Studies have shown that long-term diet, time of day, sleep, exercise, disease comorbidities, among others, all create variability in intra-subject ROS biomarkers, including MDA and DT [67][68][69][70][71][72][73][74].…”

Section: Discussionmentioning

confidence: 99%

Preliminary Effects of Osteopathic Manipulative Medicine on Reactive Oxygen Species in Parkinson’s Disease: A Randomized Controlled Pilot Study

Docherty¹,

Leheste²,

Mancini³

et al. 2022

Cureus

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Parkinson's disease (PD) is the second most common neurodegenerative disorder and causes many clinical manifestations including bradykinesia, tremor, postural instability, and musculoskeletal stiffness. Neurodegeneration is commonly associated with oxidative stress. Oxidative stress has not been measured in PD in relation to the manual techniques used in Osteopathic Manipulative Treatment (OMT). ObjectiveTo investigate the effect of OMT on oxidative stress biomarkers in PD. MethodsIn this randomized non-blinded study, 32 PD subjects were separated by block randomization into counseling and OMT groups, receiving respective interventions twice a week for six weeks. The counseling arm received informative sessions while the OMT arm received a set treatment protocol. Biomarkers of oxidative stress, malondialdehyde (MDA), dityrosine (DT), 3-nitrotyrosine (3-NT), 8-hydroxy-2deoxyguanosine (8-OHdG), and 8-isoprostane were measured before and after the first session and at weeks three, six, and 10 (four weeks after conclusion of intervention). ResultsNo significant changes were found in blood plasma levels of MDA, DT, 3-NT, or 8-OHdG during or after intervention compared to controls (p > 0.05). No significant changes were found in urine 8-OHdG or 8isoprostane during or after intervention compared to controls (p > 0.05). ConclusionOMT used in this study did not significantly affect the chosen oxidative stress biomarkers, however many limitations of the study may have impeded possible findings.

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“…Полученные результаты подтверждают благоприятное влияние снижения массы тела на качество эякулята [10][11][12][13][14]. Крупные работы, посвященные влиянию лираглутида на сперматогенез, отсутствуют.…”

Section: обсуждение основного результата исследованияunclassified

“…В других исследованиях пациенты с наибольшей потерей веса при соблюдении гипокалорийной диеты имели статистически значимое увеличение сперматозоидов с нормальной морфологией, общего количества сперматозоидов и уменьшения фрагментации ДНК [10,11]. В некоторых работах при улучшении антропометрических показателей значимо уменьшались уровни маркеров оксидативного стресса: данные показаны в серии клинических случаев, где при уменьшении абдоминального жира улучшались целостность ДНК сперматозоидов и исходы беременности, а также снижалось количество поврежденных белков в результате оксидативного стресса и увеличивался уровень супероксиддисмутазы 2 [13,25].…”

Section: научное исследованиеunclassified

Ejaculate quality indicators of men with asthenozoospermia and asthenoteratozoospermia by treatment of obesity with liraglutide

2021

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Background: Considering the influence of visceral obesity on male infertility, the investigation of ejaculate quality indicators under obesity treatment is relevant.Objective: Evaluation of ejaculate quality indicators by obesity treatment with liraglutide in andrologically healthy men with infertility and post-pubertal visceral obesity.Methods: Infertile men with post-pubertal alimentary visceral obesity were included in a pilot observational prospective study. All patients were given recommendations for body weight loss (hypocaloric diet, daily aerobic physical activity) as well as an average daily dose of liraglutide 2.4 [2.4; 3.0] mg. Evaluation of waist circumference, antioxidant activity of ejaculate, spermogram was carried out initially and after 6 months. The differences were considered statistically significant at p <0.005.Results: The body weight decrease was -11.7 [12.4; 11.0]%, the waist circumference decrease was 8 [12; 7] cm. In dynamics, increased content of living sperm in ejaculate from 92 [90; 95]% to 95 [92; 98]%, morphologically normal forms from 5 [3; 6]% to 6 [3; 8]%, mobility of A + B from 25 [15; 36] to 35 [19; 52]%, seminal antioxidant capacity, a decrease in reactive oxygen forms in the neat ejaculate were statistically significant. Increasing the sperm count in 1 ml and decreasing reactive oxygen forms in the washed ejaculate did not reach statistical significance.Conclusion: Ejaculate quality indicators improved by the complex obesity therapy with liraglutide in young andrologically healthy men with postpubertal visceral obesity.

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Effect of a hypocaloric diet in the oxidative stress in obese subjects without prescription of exercise and antioxidants

Cited by 5 publications

References 25 publications

Does weight loss affect the parameters that are metabolically related to cardiovascular diseases?

Does weight loss affect the parameters that are metabolically related to cardiovascular diseases?

Preliminary Effects of Osteopathic Manipulative Medicine on Reactive Oxygen Species in Parkinson’s Disease: A Randomized Controlled Pilot Study

Ejaculate quality indicators of men with asthenozoospermia and asthenoteratozoospermia by treatment of obesity with liraglutide

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