Effect of a new modified polyamidoamine dendrimer biomimetic system on the mineralization of type I collagen fibrils: an in vitro study

Xie, Fangfang; Long, Jindong; Yang, Jin Hyuk; Qin, Hejia; Lin, Xuandong; Chen, Wenxia

doi:10.1080/09205063.2021.1982642

Cited by 9 publications

(8 citation statements)

References 42 publications

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“…Remineralization of intrafibrillar and interfibrillar reconstituted type I collagen [210] and demineralized human dentin was established in artificial saliva or amorphous calcium phosphate stabilizing, polyacrylic acid (PAA) solution (Figure 23b) [211] and in vivo in the oral cavity of rats [212To to simulate more effectively the operation of non-collagenous dentine matrix protein, phosphorylated G4 PAMAM was combined with the respective carboxylated counterpart. The mechanical properties of hydroxyapatite produced by this blend during the mineralization process of collagen fibrils of natural dentin [213] and recombinant type I collagen fibrils [214] were further improved resembling at the nanoscale level those of the natural tissues.…”

Section: Copyright Taylor and Francismentioning

confidence: 94%

Dendritic Polymers Applications in Tissue Engineering

Arkas¹,

Vardavoulias²,

Kythreoti³

et al. 2022

Preprint

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The capability of radially polymerized bio-dendrimers and hyperbranched polymers for medical applications is well established. Among them, perhaps the most important are those that involve interactions with the regenerative mechanisms of cells. Dendritic polymers due to their distinctive architecture may play a multitude of roles such as protein biomimicry (collagen, elastin, hydroxy apatite production), gene and drug delivery (cell differentiation, antimicrobial protection), surface chemistry and charge modulation (adhesion to cells and tissues), polymer cross-linking (eye, skin and internal organ wound healing). The review highlights all the different categories of hard and soft tissues that may be remediated with their contribution. The reader will be also exposed to the incorporation methods to established biomaterials such as scaffolds, the functionalization strategies, and the synthetic paths for the assembly from biocompatible building blocks and natural metabolites.

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Section: Copyright Taylor and Francismentioning

confidence: 94%

Dendritic Polymers Applications in Tissue Engineering

Arkas¹,

Vardavoulias²,

Kythreoti³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…An in vitro cytotoxicity study of PAMAM in two cancer cell lines (SW480 and HeLa) showed that the G4 PAMAM was the least toxic, and G6 PAMAM was the most toxic, whereas SW480 showed a greater sensitivity to G5 PAMAM. In addition, proinflammatory activities were found to be related to dendrimer generations, i.e., G3 > G2 > G1 > G0 [ 48 ]. An in vivo study using a mouse model showed that G5 PAMAM can cause acute lung failure when administered via the intranasal route.…”

Section: Pamam Dendrimersmentioning

confidence: 99%

Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer

2023

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The formulation of nanoscale systems with well-defined sizes and shapes is of great interest in applications such as drug and gene delivery, diagnostics and imaging. Dendrimers are polymers that have attracted interest due to their size, shape, branching length, amine density, and surface functionalities. These unique characteristics of dendrimers set them apart from other polymers, their ability to modify nanoparticles (NPs) for biomedical applications. Dendrimers are spherical with multiple layers over their central core, each representing a generation. Their amphiphilic nature and hollow structure allow for the incorporation of multiple drugs or genes, in addition to enabling easy surface modification with cellular receptor-targeting moieties to ensure site-specific delivery of therapeutics. Dendrimers are employed in chemotherapeutic applications for the delivery of anticancer drugs. There are many inorganic NPs currently being investigated for cancer therapy, each with their own unique biological, chemical, and physical properties. To favor biomedical applications, inorganic NPs require suitable polymers to ensure stability, biodegradability and target specificity. The success of dendrimers is dependent on their unique structure, good bioavailability and stability. In this review, we describe the properties of dendrimers and their use as modifiers of inorganic NPs for enhanced therapeutic delivery. Herein, we review the significant developments in this area from 2015 to 2022. Databases including Web of Science, Scopus, Google Scholar, Science Direct, BioMed Central (BMC), and PubMed were searched for articles using dendrimers, inorganic nanoparticles and cancer as keywords.

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“…Remineralization of intrafibrillar and interfibrillar reconstituted type I collagen [ 232 ] and demineralized human dentin was established in artificial saliva or amorphous calcium phosphate stabilizing, polyacrylic acid (PAA) solution ( Figure 23 b) [ 233 ] and in vivo in the oral cavity of rats [ 234 ] To more effectively simulate the operation of non-collagenous dentine matrix protein, phosphorylated G4 PAMAM was combined with the respective carboxylated counterpart. The mechanical properties of hydroxyapatite produced by this blend during the mineralization process of collagen fibrils of natural dentin [ 235 ] and recombinant type I collagen fibrils [ 236 ] were further improved, resembling at the nanoscale level those of the natural tissues.…”

Section: Applications Of Dendritic Polymers In Dentistrymentioning

confidence: 99%

Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution

et al. 2023

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The capability of radially polymerized bio-dendrimers and hyperbranched polymers for medical applications is well established. Perhaps the most important implementations are those that involve interactions with the regenerative mechanisms of cells. In general, they are non-toxic or exhibit very low toxicity. Thus, they allow unhindered and, in many cases, faster cell proliferation, a property that renders them ideal materials for tissue engineering scaffolds. Their resemblance to proteins permits the synthesis of derivatives that mimic collagen and elastin or are capable of biomimetic hydroxy apatite production. Due to their distinctive architecture (core, internal branches, terminal groups), dendritic polymers may play many roles. The internal cavities may host cell differentiation genes and antimicrobial protection drugs. Suitable terminal groups may modify the surface chemistry of cells and modulate the external membrane charge promoting cell adhesion and tissue assembly. They may also induce polymer cross-linking for healing implementation in the eyes, skin, and internal organ wounds. The review highlights all the different categories of hard and soft tissues that may be remediated with their contribution. The reader will also be exposed to the incorporation of methods for establishment of biomaterials, functionalization strategies, and the synthetic paths for organizing assemblies from biocompatible building blocks and natural metabolites.

show abstract

Effect of a new modified polyamidoamine dendrimer biomimetic system on the mineralization of type I collagen fibrils: an in vitro study

Cited by 9 publications

References 42 publications

Dendritic Polymers Applications in Tissue Engineering

Dendritic Polymers Applications in Tissue Engineering

Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer

Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution

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