Effect of a palm-oil-vitamin E concentrate on the serum and lipoprotein lipids in humans

Abstract

The effect of a capsulated palm-oil-vitamin E concentrate (palmvitee) on human serum and lipoprotein lipids was assessed. Each palmvitee capsule contains approximately 18, approximately 42, and approximately 240 mg of tocopherols, tocotrienols, and palm olein, respectively. All volunteers took one palmvitee capsule per day for 30 consecutive days. Overnight fasting blood was taken from each volunteer before and after the experiment. Serum lipids and lipoproteins were analyzed by using the enzymatic CHOD-PAP method. Our results showed that palmvitee lowered both serum total cholesterol (TC) and low-density-lipoprotein cholesterol (LDL-C) concentrations in all the volunteers. The magnitude of reduction of serum TC ranged from 5.0% to 35.9% whereas the reduction of LDL-C values ranged from 0.9% to 37.0% when compared with their respective starting values. The effect of palmvitee on triglycerides (TGs) and HDL-C was not consistent. Our results show that the palmvitee has a hypocholesterolemic effect.

Gamma Delta Tocotrienols Reduce Hepatic Triglyceride Synthesis and VLDL Secretion

“…Clinical findings concerning the effects of T3 on circulating cholesterol, triglycerides and lipoproteins in humans are inconsistent. The four earlier studies published by Tan et al 16) and Qureshi et al 12,17) showed lipid-lowering effects (total cholesterol, LDL and triglyceride reduction) of the T3-rich fraction (TRF) from palm oil. In these studies, no changes were found in serum HDL cholesterol concentration.…”

Effects of Tocols Rich Fraction Isolated from Rice Bran Oil Deodorizer Distillate on Plasma and Hepatic Lipid Concentrations in Rats

“…Numerous studies reported that the effects of tocotrienols and tocotrienol-rich fractions on lipid metabolism in animals [26]- [29] and humans [30]- [33]. The mechanism of the hypocholesterolemic effect of tocotrienols was revealed as the suppression of 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity and inhibition of expression of HMGCoA reductase mRNA [21] [34].…”

Tocotrienols and its impact in cardiovascular health

“…42 What added to the interest in tocotrienol as a cholesterol-lowering nutrient in humans was a concurrent independent study reporting the hypocholesterolemic effects of palmvitee. 43 Each palmvitee capsule contained approximately 18, 42, and 240 mg of tocopherols, tocotrienols, and palm olein, respectively. All volunteers took one palmvitee capsule per day for 30 consecutive days.…”

“…The magnitude of reduction of serum total cholesterol ranged from 5.0% to 35.9% whereas the reduction of low-density-lipoprotein cholesterol values ranged from 0.9% to 37.0% when compared with their respective baseline values. 43 Tocotrienol, not only of palm oil origin, but also isolated from rice bran show cholesterol lowering properties. 44,45 Amaranth oil, containing tocotrienol, possesses hypocholesterolemic properties as well.…”

“…No adverse effects were reported. 43 The palm TRF was tested in 16-25 hypercholesterolemic Malaysian subjects aged 30-60 year at a dose of 200-300 mg/d over a 4-8 week period. 41,48 Significant reductions in serum total cholesterol, LDL cholesterol, apolipoprotein B, thromboxane B2, and platelet factor were observed.…”