Effect of a peri-parturient eprinomectin treatment of dairy cows on milk production

McPherson, WB; Gogolewski, R.P.; Slacek, B; Familton, A.S.; Gross, SJ; Maciel, A. L. G.; Ryan, W. G.

doi:10.1080/00480169.2001.36212

Cited by 25 publications

(12 citation statements)

References 15 publications

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“…Although higher treatment responses in older cattle may appear counterintuitive, as these animals are considered to be functionally immune to gastrointestinal nematodes, several previous studies reported higher treatment responses with increasing cow age [3,13,25]. As discussed before [3], the latter may be attributed to a different priority of nutrient allocation between primi-and multiparous cows [13] or the higher energy requirements of the immune response to GI nematodes in older animals, as observed in sheep [32]. Finally, it may also be considered that the level of GI nematode infection in primiparous cows is generally lower than in older cows.…”

Section: Discussionmentioning

confidence: 99%

“…The parameter yielding most consistent results is the anti-Ostertagia ostertagi antibody level in individual milk samples, with studies showing higher treatment responses in cows with a high antibody level [3,11,12,16]. As for the age of the cow, some studies found no relationship with treatment effect [10,14,17], whereas others reported a higher milk yield gain in older cows [3,13] or conversely, in younger cows [5]. Finally, it was suggested that treatment responses were higher in high producing animals [14,18], but this was not observed by others [10].…”

Section: Introductionmentioning

confidence: 92%

“…However, a cost-benefit analysis suggested that the economic benefit of anthelmintic treatment of dairy cows is considerably larger when cows are treated around calving compared to treatment at housing [9]. Studies assessing the effect of anthelmintic treatment around calving have been carried out in Canada [10][11][12] and New Zealand [13], but significant differences in climate and farm management practices may result in different parasite epidemiology and different production effects when compared to European circumstances.…”

Section: Introductionmentioning

confidence: 99%

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Non-invasive indicators associated with the milk yield response after anthelmintic treatment at calving in dairy cows

et al. 2014

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Background: Gastrointestinal nematodes are an important cause of reduced performance in cattle. Previous studies in Europe showed that after anthelmintic treatment an average gain in milk production of around 1 kg per day/ cow can be expected. However, (1) these studies have mainly evaluated group-based anthelmintic treatments during the grazing season or at housing and (2) little is known about parameters affecting variations in the treatment response amongst cows. A better knowledge of such parameters could help to select animals that benefit most from treatment and thus lead to a more rational use of anthelmintics. Therefore, a randomized, non-blinded, controlled clinical trial was performed on 11 commercial dairy farms (477 animals) in Belgium, aiming (1) to study the effect of eprinomectin treatment at calving on milk production and (2) to investigate whether the milk yield response was related to non-invasive animal parameters such that these could be used to inform targeted selective treatment decisions. Results: Analyses show that eprinomectin treatment around calving resulted in an average (± standard error) increase of 0.97 (±0.41) kg in daily milk yield that was followed up over 274 days on average. Milk yield responses were higher in multiparous compared to primiparous cows and in cows with a high (4 th quartile) anti-O. ostertagi antibody level in a milk sample from the previous lactation. Nonetheless, high responses were also seen in animals with a low (1 st quartile) anti-O. ostertagi antibody level. In addition, positive treatment responses were associated with higher faecal egg counts and a moderate body condition score at calving (2 nd quartile).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Non-invasive indicators associated with the milk yield response after anthelmintic treatment at calving in dairy cows

et al. 2014

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“…The cattle were naturally infested with C. bovis, as confirmed by examination of skin scrapings taken the day before treatment (day −1). To exclude effects on production resulting from the anthelmintic properties of eprinomectin (Little et al 2000;Zaffaroni et al 2000;McPherson et al 2001;Nødtvedt et al 2002), all animals were dewormed with oral fenbendazole (Panacur Suspension 10%, Hoechst Roussel Vet, Germany) administered at twice the manufacturer's recommended dose on day −6.…”

Section: Methodsmentioning

confidence: 99%

Chorioptic mange in dairy cattle: treatment with eprinomectin pour-on

Rehbein¹,

Winter²,

Visser³

et al. 2005

Parasitol Res

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A randomized block design study was conducted to confirm the efficacy of topical eprinomectin against naturally acquired Chorioptes bovis mite infestations. Twelve adult Simmentaler Fleckvieh cattle were formed into six replicates of two animals based on pretreatment mite counts. Within replicates, animals were randomly allocated to untreated controls or were treated with eprinomectin 0.5% pour-on solution at 1 mL/10 kg body weight (0.5 mg eprinomectin/kg body weight). Live mites were counted, and mange lesions were scored prior to treatment and at weekly intervals until the end of the study on day 56. Feed consumption was recorded daily throughout the study, and body weights were measured. Differences between variables were declared significant if p < or = 0.05. Mite counts for the cattle treated with eprinomectin were reduced by 100% from day 14 through the end of the study (p < 0.05). At each examination from day 21 through the end of the study, treated animals were significantly clinically improved as measured by lesion scoring compared with untreated controls. Weight gain and feed conversion efficiency were numerically higher in the eprinomectin-treated group. Results of this study demonstrate a positive response in growth rate following effective treatment of cattle for chorioptic mange and underline the economic importance of the parasite and the value of treatment.

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“…No other MLs are approved for treatment of dairy animals. There is concern that unapproved ML products may be used in dairy animals, especially when there are claims that use of the approved (and more expensive) drug eprinomectin can increase milk yield [86,87]. Concerns over the presence of ML residues in milk are supported by the fact that as much as 5% of the drug dosage may be excreted in milk after treatment with certain unapproved ML products [33,37,72].…”

Section: Monitoring For Macrocyclic Lactone Residues In Foodmentioning

confidence: 97%

Review of methodology for the determination of macrocyclic lactone residues in biological matrices

Danaher

Howells

Crooks

et al. 2006

Journal of Chromatography B

125

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Effect of a peri-parturient eprinomectin treatment of dairy cows on milk production

Abstract: These data provide evidence that the use of a peri-parturient treatment of eprinomectin on multiparous cows can increase their production of fluid milk and milksolids.

Cited by 25 publications

References 15 publications

Non-invasive indicators associated with the milk yield response after anthelmintic treatment at calving in dairy cows

Non-invasive indicators associated with the milk yield response after anthelmintic treatment at calving in dairy cows

Chorioptic mange in dairy cattle: treatment with eprinomectin pour-on

Review of methodology for the determination of macrocyclic lactone residues in biological matrices

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