Effect of a Permanent Magnetic Field on Blood Pressure Regulation

Static magnetic field blood pressure buffering, baroreflex vs. vascular blood pressure control mechanism

“…Theoretical considerations suggest that the applied SMF may influence sinocarotid baroreceptor sensory transduction, modifying the baroreceptor Ca 2þ dependent gated depolarisation region as well as stretch activated Ca 2þ channels on the baroreceptor spike initiating zone (Gmitrov 2007b). Hemodynamic effects of baroreceptor exposed to an SMF in rabbits were observed earlier in experiments under the condition of total pentobarbital anesthesia, where much smaller and weaker SmCo alloy magnets (cross-sectional area 23 mm 2 , 200 mT) were positioned exactly over operatively approached glomus caroticum (Gmitrov et al 1990). These effects were already observed under conscious condition without pentobarbital sedation (Gmitrov et al 1995).…”

“…This approach allows identification of most sensitive biological structures and determination of mechanisms or sequences of changes in physiological functions that give rise to the observed biological effects. It has already been reported earlier that SMF of different intensity significantly affect hemodynamics including blood pressure, heart rate (Beischer 1969, Jehenson et al 1988, Gmitrov et al 1990, 1995, Lazetic and Pekaric-Nadj 1993, Gmitrov 1996, Okano and Ohkubo 2001, 2005a, 2005b, Veliks et al 2004) and microcirculation (Okano et al 1999, Gmitrov et al 2002, Morris and Skalak 2005, 2008, Gmitrov 2007b. It is widely recognised that arterial baroreceptors play a key role in the operation of cardiovascular functions and in the reflex regulation of blood pressure, under normal and pathological conditions.…”

Geomagnetic field modulates artificial static magnetic field effect on arterial baroreflex and on microcirculation

“…Most likely increased geomagnetic activity suppressed brain steam and higher baroreflex regulatory centers (Gmitrov and Gmitrova 2004), counteracting SMF local stimulatory effect on arterial baroreceptors and on baroreflex-mediated microcirculatory response. The stimulatory effect of the sinocarotid baroreceptors was recognized in our previous experiments with weaker SMFs, generated by much smaller SmCo magnets (cross-sectional area 23 mm 2 , 200 mT), positioned precisely under visual control over operatively approached glomus caroticus in the condition of total pentobarbital anesthesia (Gmitrov et al 1990;Gmitrov and Gmitrova 1994), and in conscious rabbits (without pentobarbital sedation, 240 mT) (Gmitrov et al 1995). Similarly as in conscious animals, in the condition of pentobarbital anesthesia, GMF disturbance reduced SMF evoked sinocarotid baroreceptor-mediated hemodynamic response (Gmitrov and Gmitrova 1994).…”

Static Magnetic Field Effect on Sinocarotid Baroreceptors in Humans

“…We showed that local application of 0.2 T SMF on operatively approached carotid sinuses in rabbits under pentobarbital anesthesia had (1) a hypotensive effect under conditions of (a) normotonia and (b) norepinephrine-induced arterial hypertension, and (2) SMF reduced the hypotensive effect of aortic nerve electrostimulation. SMF hemodynamic effects were abolished by infusion of verapamil, a potent calcium channel blocking agent (1)(2)(3)(4)(5)(6)(7).…”