Effect of a Phytonutrient-Rich Product and Administration Time on Cyanide-Induced Cardiotoxicity

Ilesanmi, Omotayo B.; Atanu, Francis O.; Odewale, Temitope T.; Adeogun, Esther F.; Chikere, Bruno; Alaneme, Chinenyenwa; Ogonye, David; Ogbonna, Joy

doi:10.26538/tjnpr/v4i7.9

Cited by 6 publications

(5 citation statements)

References 21 publications

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“…Additionally, it contains ascorbic acid, tocopherol, retinoic acid, essential amino acids, essential fatty acids, and nutrients (both micro and macro) that contribute to its health benefits. We had shown the protective effects of Trévo on the liver, kidney, and brain using various toxic chemicals in other studies [25,26]. Here, we investigated the protective effects of Trévo against the biochemical alterations in the hippocampus following exposure to Cd.…”

Section: Introductionmentioning

confidence: 97%

Neuroprotective (Antioxidant, Antiamyloidogenic, and Antiexcitatory) Effects of TrévoTM against Cadmium Chloride Neurotoxicity in Adult Male Wistar Rats

Ilesanmi¹,

Okotie²,

Adeogun³

et al. 2022

OBM Neurobiol

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Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain aging. Trévo is a multi-herbal supplement that provides various health benefits, including boosting the immune system and detoxification. In this study, we investigated the neuroprotective effects of Trévo against the neurotoxic effects of cadmium chloride (CdCl2). Thirty male Wistar rats were equally divided into three groups: Group I (normal control), Group II (administered CdCl2), and Group III (administered Trévo and CdCl2), and were used in the experiments. Animals were pretreated with 2 mL/kg of Trévo for five days and injected with Cd intraperitoneally 3 h later. Cd significantly increased the production of malondialdehyde (MDA), amyloidogenesis, activation of caspase 3 and 9, and the production of p53 and glutamate. It also inhibited the activity of Na+/K+ ATPase, glutamate dehydrogenase, catalase, superoxide dismutase, and glutathione-S-transferase. The administration of Trévo revealed its antioxidant, anti-amyloidogenic, anti-excitotoxicity, and anticholinesterase properties as it prevented the biochemical changes induced by Cd toxicity in the brain of male Wistar rats. Our results supported the reported health benefits of Trévo as a good dietary supplement in preventing the toxic effects of poisonous substances, such as cadmium.

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Section: Introductionmentioning

confidence: 97%

Neuroprotective (Antioxidant, Antiamyloidogenic, and Antiexcitatory) Effects of TrévoTM against Cadmium Chloride Neurotoxicity in Adult Male Wistar Rats

Ilesanmi¹,

Okotie²,

Adeogun³

et al. 2022

OBM Neurobiol

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“…According to the manufacturer, daily intake of Trévo TM provides the body with a high concentration of antioxidants that can prevent the generation of free radicals, thus countering or slowing down the effect of toxic chemicals and poison. Recent investigations show that Trévo TM was protective against acetaminophen, cyanide-induced liver damage [19,20], in addition to its neuroprotective and cardioprotective activities [21,22]. This study investigated the effectiveness of Trévo TM to protect against lead-induced biochemical and histological changes in the liver of male Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

Lead exposure-induced changes in hematology and biomarkers of hepatic injury: protective role of TrévoTM supplement

Ilesanmi

Adeogun

Odewale

et al. 2022

Environ Anal Health Toxicol

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Lead exposure has been linked to health challenges involving multiple organ failure. More than fifty percent of lead present in the human body is accumulated in the liver causing hepatic injury. A major mechanism of lead toxicity is oxidative stress. TrévoTM is a nutritional supplement with numerous bioactive natural products with detoxifying and antioxidant properties. This study was designed to investigate the hepatoprotective effects of TrévoTM dietary supplements against lead-hepatotoxicity in male Wistar rats. Thirty-five healthy animals were divided into five groups of seven each as follows: Group I=control; II=15 mg/kg of lead acetate (PbA); III= 2 mL/kg of TrévoTM + PbA; IV= 5 mL/kg of TrévoTM + PbA;V=5 mL/kg of TrévoTM . Animals were orally treated with TrévoTM for two days before co-administration with PbA intraperitoneally for 12 consecutive days. Animals were sacrificed 24 h after the last administration and blood were collected via cardiac puncture and processed for hematological parameters and assessment of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and albumin (ALB). The liver was excised and processed for markers of oxidative stress and histopathological examination. Intraperitoneal administration of 15 mg/kg of PbA caused a significant increase in serum concentration of AST, ALT, while the concentration of ALB was significantly decreased (P<0.001). PbA caused a significant reduction in packed cell volume, hemoglobin while the total white blood cell count, neutrophils, lymphocytes, monocytes, eosinophils, and basophils were increased. Oxidative stress was significantly pronounced in the liver of rats exposed to PbA as observed in the high concentration of malonedialdehyde, decreased concentration of glutathione, the activity of catalase, superoxide dismutase, and glutathione-S-transferase. Pretreatment with TrévoTM was able to significantly prevent the anemic, oxidative damage, and hepatic injury initiated by PbA. Histological examination also corroborated the biochemical results. In conclusion, the study reveals that TrévoTM is effective in attenuating PbA-induced hepatotoxicity in male Wistar rats.

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“…It is commercially promoted as a blood purifying, immune booster, detoxifier, and regenerating product that improves the health and well-being of individuals. Also, the anticancer, and the protective effects of trevo on the liver, heart and nervous system against various toxins have been reported [21][22][23]. In an earlier study, we have reported the protective activity of trévo against cyanide-induced nephrotoxicity [24].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effect of Trevo Dietary Supplement Against Lead Acetate Nephrotoxicity

Ilesanmi

Agoro

2022

IJT

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Background: Trevo is a nutritional supplement with numerous bioactive natural products, with detoxifying and antioxidant properties. The purpose of this study was to investigate the ability of Trévo to protect against oxidative stress induced by lead in the kidneys of male Wistar rats. Methods: Thirty-five healthy male Wistar rats were divided into five groups of seven rats each, using a randomized design. I=control; II=15 mg/kg of lead acetate (PbA); III=2 ml/kg of trevo+PbA; IV=5 ml/kg of trevo+PbA; V=5 ml/kg of trevo. Animals were treated with trevo for five days before co-administration with lead intraperitoneally for 10 consecutive days. Animals were sacrificed 24hr after the last administration, blood samples were collected via cardiac puncture, and processed for assessment of urea, creatinine, and uric acid (UA), while the kidney samples were excised and processed for the following biochemical assays: Malondialdehyde (MDA), Glutathione-S-Transferase (GST), Catalase (CAT), Superoxide Dismutase (SOD), and Reduced Glutathione (GSH). Results: Injection of PbA caused a significant increase in the serum levels of urea, creatinine, and uric acid, and a significant increase (P<0.001) in the MDA concentration, and decreases in GSH concentration, CAT, SOD, and GST activities (P<0.05) as compared to the controls. Pretreatment with trevo prevented the oxidative stress induced by lead acetate in the kidney tissue samples and improve the renal function. The protective effect was evident at 5 ml/kg of trevo. Conclusion: The results showed that trevo was nephroprotective against lead toxicity and the activity might be linked to the presence of numerous antioxidant phytochemicals present in trevo.

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Effect of a Phytonutrient-Rich Product and Administration Time on Cyanide-Induced Cardiotoxicity

Cited by 6 publications

References 21 publications

Neuroprotective (Antioxidant, Antiamyloidogenic, and Antiexcitatory) Effects of Trévo<sup>TM</sup> against Cadmium Chloride Neurotoxicity in Adult Male Wistar Rats

Neuroprotective (Antioxidant, Antiamyloidogenic, and Antiexcitatory) Effects of Trévo<sup>TM</sup> against Cadmium Chloride Neurotoxicity in Adult Male Wistar Rats

Lead exposure-induced changes in hematology and biomarkers of hepatic injury: protective role of TrévoTM supplement

Ameliorative Effect of Trevo Dietary Supplement Against Lead Acetate Nephrotoxicity

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