Effect of a Polysaccharide (TAP) from the Fruiting Bodies ofTremella aurantiaon Glucose Metabolism in Mouse Liver

Mushrooms as therapeutic agents

“…The β-glucans isolated from A. cylindracea showed remarkable hypoglycemic activity in both normal and STZ-induced diabetic mice when administered intraperitoneally. The antidiabetic activity of Tremella aurantia may also be mediated by an increase in the activities of glucokinase, hexokinase, and glucose-6-phosphate dehydrogenase and a decrease in the activity of glucose-6-phosphatase in normal and IDDM diabetic mouse livers after intraperitoneal administration (Kiho et al, 2000). Another acidic polysaccharide from the fruiting bodies of T. fuciformis was found to be effective in STZinduced diabetic mice when administered orally .…”

“…Many studies have been conducted on the hypoglycemic activity of whole mushrooms and their fruiting bodies (Horio et al, 2001) and on mushroom bioactive components, including polysaccharides Kiho et al, 2002;Kiho et al, 2000;Kiho et al, 1995) and lectins (Ewart et al, 1975) isolated from the fruiting bodies. Moreover, endo and exopolymers produced in submerged mycelial cultures have also been found to have a hypoglycemic effect (Kim et al, 2001;Kim et al, 1997).…”

Hypoglycemic effect of crude exopolysaccharides produced byCerrena unicolor,Coprinus comatus, andLenzites betulinaisolates in streptozotocin- induced diabetic rats

“…The hypoglycemic activities of ganoderan A and B (Hikino et al, 1985), coriolan (Ikuzawa et al, 1985), and an acidic glucuronoxylomannan (Kiho et al, 2000) have been reported. Although there are some reports on the hypoglycemic effects of mushroom exopolysaccharides (EPS) (Kim et al, 2001b(Kim et al, , 2001cYang et al, 2002;, most of these studies were carried out with the fruiting bodies (Kubo et al, 1994;Gray & Flatt, 1998;Lo et al, 2006), submerged culture biomass (Kim et al, 2001a;Han et al, 2006;Lo et al, 2006;Yang et al, 2006) or intracellular polysaccharides (Kiho et al, 1993(Kiho et al, , 1994(Kiho et al, , 1995(Kiho et al, , 1996Yuan et al, 1998).…”

Nutritional Value and Health Benefits of Mushrooms

“…The antidiabetic acidic polysaccharide isolated from T. aurantia has a branched structure with a (1 ! 4)-Þ-linked-D-mannopyranosyl backbone and side chains of þ-D-xylopyranosyl residues, with þ-D-glucuropyranosyluronic residues linked to the terminal Þ-D-mannopyranose (Kiho et al, 2000). Tremella aurantia has been shown to exert its hypoglycemic effect in diabetic mouse models of both IDDM and NIDDM following intraperitoneal administration (Kiho et al, 1995).…”