Effect of a progesterone-releasing intravaginal device on the milk progesterone levels, vaginal flora, milk yield and fertility of cyclic and non-cyclic dairy cows

Bulman, D.C.; McKibbin, P.E.; Appleyard, WT; Lamming, G. E.

doi:10.1530/jrf.0.0530289

Cited by 27 publications

(12 citation statements)

References 17 publications

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“…In the present study, VS did not affect pregnancy risk at first service, interval from insertion to AI, or interval from calving to pregnancy. Bulman et al (1978) genic bacteria after a 14-d PRID treatment in 9 of 10 cows; but no growth was obtained in repeat sampling 7 d later . Given the lack of impact on our outcomes of interest, this indicates that no reason likely exists to delay AI in cows displaying estrus based on the condition of the device at removal.…”

Section: Discussionmentioning

confidence: 93%

Synchronization of Estrus and Pregnancy Risk in Anestrous Dairy Cows After Treatment with a Progesterone-Releasing Intravaginal Device

Walsh

LeBlanc

Duffield

et al. 2007

Journal of Dairy Science

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Lactating Holstein cows (located in 4 dairy herds) that had failed to display estrus as defined by increased pedometer activity by 63 +/- 3 d in milk, were enrolled to investigate the effect of a progesterone-releasing intravaginal device (PRID, n = 268) relative to a placebo intravaginal device (PID, control, n = 266) on days from device removal to artificial insemination (AI), the probability of pregnancy at first AI, and days from device removal to pregnancy. Cows were assigned randomly to receive a PRID or PID for 7 d and an injection of PGF2alpha at device removal. Upon device removal, a vaginitis score was assigned and AI occurred at observed estrus. Cows failing to display estrus within 14 d of device removal were subjected to a subsequent reproductive exam and were treated with PGF2alpha. Two percent of PRID-treated cows and 11% of control cows displayed estrus during the 7-d exposure period. Among the remaining cows, 93% of the devices were present at the scheduled removal. Cows treated with the PRID were 60% less likely to have purulent debris on the device than control cows. Vaginal reaction, however, was not associated with any of the reproductive outcomes. Investigation of the reproductive outcomes revealed a treatment x parity interaction. Progesterone-treated primiparous cows were inseminated 17 d earlier, with no significant change in the probability of pregnancy at first AI (30.3 vs. 42.0%), and no difference in median time from device removal to pregnancy (52 vs. 53 d) relative to control primiparous cows. Conversely, PRID-treated multiparous cows were inseminated 8 d earlier, with no change in probability of pregnancy at first AI (24.6 vs. 18.8%); however, median time from device removal to pregnancy was reduced by 20 d (67 vs. 87 d). These results support the efficacy of a PRID to induce estrus in previously anestrous cows. The reason, however, for the variable response between primiparous and multiparous cows was not clear.

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Section: Discussionmentioning

confidence: 93%

Synchronization of Estrus and Pregnancy Risk in Anestrous Dairy Cows After Treatment with a Progesterone-Releasing Intravaginal Device

Walsh

LeBlanc

Duffield

et al. 2007

Journal of Dairy Science

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“…The frequency increased in older animals and 13-3 % (10/75) of those in their 6th to 11th lactations were classified in this way. The effect of treatment on the fertility of cows with a delayed start to cyclicity after parturition has been described elsewhere Bulman, McKibbin, Appleyard & Lamming, 1978). Some of this information plus additional data are summarized in Table 4.…”

Section: Studymentioning

confidence: 99%

Milk progesterone levels in relation to conception, repeat breeding and factors influencing acyclicity in dairy cows

Bulman¹,

Lamming²

1978

Reproduction

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308

122

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“…Dolezel et al [11] reported a similar recovery rate of 60% after PRID treatment. Bulman et al [10] reported 88% of cows with inactive ovaries ovulated after PRID treatment. Recovery rate can be improved, if gonadotropin such as eCG is given at the time of PRID removal.…”

Section: Discussionmentioning

confidence: 99%

Clinical Response of Inactive Ovaries in Dairy Cattle after PRID Treatment.

Zulu

Nakao

Yamada

et al. 2000

Journal of Reproduction and Development

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Abstract. The aim of this study was to evaluate the therapeutic effects and safety of progesterone releasing intravaginal device (PRID) in the treatment of inactive ovaries in dairy cattle. The possible influence of PRID on metabolic and/or health status was also examined. A total of 30 anestrous Holstein-Friesian cows, which on rectal palpation had small, flat and smooth or rounded ovaries were used for the experiment. PRID or placebos were inserted into the vagina and left in place for 12 days. Four animals lost the intravaginal device and one was culled. At the time of PRID insertion, the other 25 animals were divided in two groups: 18 with a progesterone concentration ≤1.0 ng/ml (group A), of which 16 were treated with PRID and 2 with placebos, and 7 with a progesterone concentration >1.0 ng/ml (group B), of which 5 were treated with PRID and 2 with placebos. Of the 16 treated animals in group A, 8 (50%) had a corpus luteum (CL) within 14 days after PRID removal. Of the 5 treated animals in group B, 3(60%) had a CL within 14 days after PRID removal. The mean interval from PRID removal to estrus was 2.7 ± 0.3 and 3.0 ± 1.0 days (± SE) in group A and B, respectively. The conception rate of cows in group A that recovered after treatment with PRID, was 28.6%. No significant changes were observed in hematocrit (Ht), WBC and serum levels of glucose, BUN, AST and ALT at the time of PRID insertion and removal, both within and between animals that recovered and those that did not. PRID is an effective treatment for inactive ovaries in dairy cattle and does not adversely affect metabolic and/or health status of animals. Further study is required to improve conception rate at the induced estrus.

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Effect of a progesterone-releasing intravaginal device on the milk progesterone levels, vaginal flora, milk yield and fertility of cyclic and non-cyclic dairy cows

Cited by 27 publications

References 17 publications

Synchronization of Estrus and Pregnancy Risk in Anestrous Dairy Cows After Treatment with a Progesterone-Releasing Intravaginal Device

Synchronization of Estrus and Pregnancy Risk in Anestrous Dairy Cows After Treatment with a Progesterone-Releasing Intravaginal Device

Milk progesterone levels in relation to conception, repeat breeding and factors influencing acyclicity in dairy cows

Clinical Response of Inactive Ovaries in Dairy Cattle after PRID Treatment.

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