Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon

Borrelli, Francesca; Izzo, Angelo A.; Carlo, Giulia Di; Maffia, Pasquale; Russo, Alessandra; Maiello, Francesco; Capasso, Francesco; Mascolo, Nicola

doi:10.1016/s0367-326x(02)00189-2

Cited by 86 publications

(39 citation statements)

References 12 publications

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“…The results of an in vivo study presented by Borrelli et al [73] showed the efficacy of CAPE in limiting tumor growth in a rat model of colon cancer. Azoxymethane (AOM) administered intraperitoneally induced formation of aberrant crypt foci (ACF) and tumors in the rat colon.…”

Section: In Vivo Studiesmentioning

confidence: 99%

The anticancer activity of propolis

Sawicka

Car

Borawska

et al. 2012

Folia Histochem Cytobiol.

173

109

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Propolis and its compounds have been the subject of many studies due to their antimicrobial and antiinflammatory activity; however, it is now known that they also possess antitumor properties. This review aims to summarize the results of studies on the mechanism of activity of propolis and its active compounds such as CAPE and chrysin in the apoptotic process, and their influence on the proliferation of cancer cells. Our review shows that propolis and its presented compounds induce apoptosis pathways in cancer cells. The antiproliferative effects of propolis, CAPE or chrysin in cancer cells are the result of the suppression of complexes of cyclins, as well as cell cycle arrest. The results of in vitro and in vivo studies suggest that propolis, CAPE and chrysin may inhibit tumor cell progression and may be useful as potential chemotherapeutic or chemopreventive anticancer drugs.

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Section: In Vivo Studiesmentioning

confidence: 99%

The anticancer activity of propolis

Sawicka

Car

Borawska

et al. 2012

Folia Histochem Cytobiol.

173

109

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show abstract

“…The propolis is a by-product of the bee keeping and it has been known for its multiple therapeutic activities in traditional medicine since antiquity. Indeed, it was reported that the propolis exerts multiple effects such as antibacterial, antifungal, antiviral, pest-destroying (Marcucci, 1995), anti-infl ammatory, antioxidant and anti-cancer activities (Borrelli et al, 2002;Banskota et al, 1998). This product has also an immuno-modulatory activity (Suzuki et al, 2002), particularly by activation of the macrophages (Orsolic et al, 2003;Almeida et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the in vitro and in vivo anticancer properties of Moroccan propolis extracts

Mouse

Tilaoui

Jaafari

et al. 2012

Rev. bras. farmacogn.

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This investigation aimed to evaluate the in vitro and in vivo antitumor potential of a Moroccan propolis extracts. For in vitro assays, three mammalian tumor cell lines were used: BSR (hamster renal adenocarcinoma), Hep-2 (human laryngeal carcinoma) and P815 (murin mastocytoma). The propolis ethanolic extract as well as the ethyl acetate extract, exert an in vitro cytotoxic activity in dose-dependent manner. The IC50 values were ranging from 15 µg/mL to 38 µg/mL. This activity depends not only on the extract's chemical composition (analysed by HPLC/ESI-MS), but also on the target tumor cells. Interestingly, the cytotoxic effect of these extracts on the normal human peripheral blood mononuclear cells (PBMC) was weak when compared to that induced on tumor cells. On the other hand, oral route treatment of P815 tumor-bearing mice (DBA2/P815) with propolis ethanolic extract (5 mg per mouse every fourth day, fi ve times for group A, and 2.5 mg per mouse every fourth day, fi ve times for group B) signifi cantly reduced the tumor volume (1.2 cm 3 for group A and 2.7 cm 3 for group B at the 22 nd day after tumor graft). These effects are statistically signifi cant as compared to those obtained with the control untreated mice (tumor volume 3.5 cm 3 at day 22).

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“…CAPE have been investigated for activities which include anti-bacterial, anti-fungal, anti-cancer, anti-inflammatory and anti-viral (Son and Lewis, 2002;Koltuksuz et al, 2001;Michaluart et al, 1999;Borrelli et al, 2002;Frenkel et al, 1993;Huang et al, 1996;Yang, 2005). while investigating the chemopreventive role of CAPE, found that the molecule exerted anti-metastatic effect via inhibiting levels of both metalloproteinase i.e (MMP-2, MMP-9).…”

mentioning

confidence: 99%

Caffeic Acid Phenethyl Ester (Cape) Mediated Decrease in Metastasis of Colon Cancer Cells: An in Vitro and in Vivo Study

Wu¹,

Gao²,

Heng³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Caffeic acid phenethyl ester (CAPE) is a phytochemically active component obtained from honeybee hive propolis. CAPE has been reported to show antimitogenic, anticancer, and other beneficial medicinal properties. Many of its activities have been reported to be mediated by inhibiting levels of matrix metalloproteinase, that is, MMP-2 and MMP-9. We hypothesize the effect of CAPE on the metastasis of colon cancer cells in both in vitro and in vivo. Methods: Cell migration, motility, invasion were evaluated also expression of protein and matrix metalloproteinases (MMPs) such as MMP-2 and MMP-9 were measured in SW-480 cancer cells in vitro. The cells were exposed to Phorbol 12-myristate 13-acetate (PMA) and were treated with various concentration of CAPE. Results: The treatment of CAPE caused significant decrease (P<0.05) in both cell motility and invasion. The treatment of CAPE inhibited activity of MMP-2 and MMP-9 and their protein with increasing dose in SW-480 cancerous cells. Antimetastatic activity was evaluated in vivo in BALB/c mice by injecting them with CT-26 mouse colon cancer cells via tail vein and were treated with CAPE (20 mg/kg) orally for 21 days. The CAPE treatment significantly (P<0.05) reduced count of pulmonary nodules. The mice showed decreased plasma MMP-2 and MMP-9 activity after 21 days treatment with CAPE. Conclusion:The study suggested beneficial role of CAPE in preventing invasion of colon cancer and metastasis via MMP-2 and MMP-9 mediated pathway.

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Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon

Cited by 86 publications

References 12 publications

The anticancer activity of propolis

The anticancer activity of propolis

Evaluation of the in vitro and in vivo anticancer properties of Moroccan propolis extracts

Caffeic Acid Phenethyl Ester (Cape) Mediated Decrease in Metastasis of Colon Cancer Cells: An in Vitro and in Vivo Study

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