Effect of a prostaglandin EP4 receptor agonist on early fixation of hydroxyapatite/titanium composite‐ and titanium‐coated rough‐surfaced implants in ovariectomized rats

Hayashi, Kazuo; Fotovati, Abbas; Ali, Shahid; Nakamura, Yoshinari; Inagaki, Masahiko; Naito, Masatoshi

doi:10.1002/jbm.a.32444

Cited by 8 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…146 Hayashi et al demonstrated that titanium-coated rough-surfaced implants had an increased implant fixation strength, if osteoporotic animals were treated with a selective EP4-prostaglandin receptor agonist. 147 Bone Morphogenetic Protein 2 is a clinically approved growth factor for facilitating bone regeneration. Over decades, BMP-2 has shown its osteoinductive properties in various biomaterial scaffolds.…”

Section: Stimulating An Atrophic Environment Around Implants Towards ...mentioning

confidence: 99%

“…In contrast the local release of a selective EP4‐prostaglandin receptor agonist from a mineralized collagen scaffold can increase bone formation 146 . Hayashi et al demonstrated that titanium‐coated rough‐surfaced implants had an increased implant fixation strength, if osteoporotic animals were treated with a selective EP4‐prostaglandin receptor agonist 147 …”

Section: How Can We Modulate the Inflammatory And Foreign Body Respon...mentioning

confidence: 99%

See 1 more Smart Citation

Friend or foe? Inflammation and the foreign body response to orthopedic biomaterials

Gibon,

Takakubo,

Zwingenberger

et al. 2023

J Biomedical Materials Res

View full text Add to dashboard Cite

The use of biomaterials and implants for joint replacement, fracture fixation, spinal stabilization and other orthopedic indications has revolutionized patient care by reliably decreasing pain and improving function. These surgical procedures always invoke an acute inflammatory reaction initially, that in most cases, readily subsides. Occasionally, chronic inflammation around the implant develops and persists; this results in unremitting pain and compromises function. The etiology of chronic inflammation may be specific, such as with infection, or be unknown. The histological hallmarks of chronic inflammation include activated macrophages, fibroblasts, T cell subsets, and other cells of the innate immune system. The presence of cells of the adaptive immune system usually indicates allergic reactions to metallic haptens. A foreign body reaction is composed of activated macrophages, giant cells, fibroblasts, and other cells often distributed in a characteristic histological arrangement; this reaction is usually due to particulate debris and other byproducts from the biomaterials used in the implant. Both chronic inflammation and the foreign body response have adverse biological effects on the integration of the implant with the surrounding tissues. Strategies to mitigate chronic inflammation and the foreign body response will enhance the initial incorporation and longevity of the implant, and thereby, improve long‐term pain relief and overall function for the patient. The seminal research performed in the laboratory of Dr. James Anderson and co‐workers has provided an inspirational and driving force for our laboratory's work on the interactions and crosstalk among cells of the mesenchymal, immune, and vascular lineages, and orthopedic biomaterials. Dr. Anderson's delineation of the fundamental biologic processes and mechanisms underlying acute and chronic inflammation, the foreign body response, resolution, and eventual functional integration of implants in different organ systems has provided researchers with a strategic approach to the use of biomaterials to improve health in numerous clinical scenarios.

show abstract

Section: Stimulating An Atrophic Environment Around Implants Towards ...mentioning

confidence: 99%

Section: How Can We Modulate the Inflammatory And Foreign Body Respon...mentioning

confidence: 99%

Friend or foe? Inflammation and the foreign body response to orthopedic biomaterials

Gibon,

Takakubo,

Zwingenberger

et al. 2023

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

Pharmacologic Augmentation of Implant Fixation in Osteopenic Bone

Ross

Hamilton

Wilson

et al. 2013

Curr Osteoporos Rep

View full text Add to dashboard Cite

Osteoporosis presents a challenge for successful implant fixation due to an impaired healing response. Preclinical studies have consistently reported reduced osseointegration capability in trabecular bone. Although clinical studies of implant success in dentistry have not found a negative effect due to osteoporosis, low bone mass is a significant risk factor for implant migration in orthopedics. Pharmacologic treatment options that limit bone resorption or upregulate formation have been studied preclinically. While, both treatment options improve implant fixation, direct comparisons to-date have found anti-catabolic more effective than anabolic treatments for establishing implant fixation, but combination approaches are better than either treatment alone. Clinically, anti-catabolic treatments, particularly bisphosphonates have been shown to increase the longevity of implants, while limited clinical evidence on the effects of anabolic treatment exists. Preclinical experiments are needed to determine the effects of osteoporosis and subsequent treatment on the long-term maintenance of fixation and recovery after bone loss.

show abstract