Effect of a Short Maximal Physical Exercise on Coagulation, Fibrinolysis, and Complement System

Dufaux, B.; Order, U.; Liesen, H.

doi:10.1055/s-2007-1024748

Cited by 72 publications

(62 citation statements)

References 9 publications

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“…Some confusion is apparent in the literature regarding the post-exercise serum concentrations of immunoglobulins and complements which have been variously reported to remain unchanged, to decrease or to increase (35)(36)(37)(38). In the present study, the rate of change in C4 following the UEL was significantly lower in females than in males at Post-Camp.…”

Section: Discussioncontrasting

confidence: 61%

Measuring neutrophil functions might be a good predictive marker of overtraining in athletes

et al. 2008

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In order to develop a predictive marker of overtraining in athletes, we examined the changes in neutrophil function [reactive oxygen species (ROS) production capability and phagocytic activity (PA)] for 10 male and 13 female judoists attending a training camp. Measurements were taken four times in total--immediately before and after a 2 h unified exercise loading (UEL) performed 1 day before (Pre-Camp) and the day after the 7 day training camp (Post-Camp). UEL-mediated aspartate aminotransferase was higher at Post-Camp than at Pre-Camp in females but not in males. Post-Camp leukocyte/neutrophil counts after the UEL significantly increased in females but not in males. The rate of change in C4 was significantly smaller in females than in males at Post-Camp. Only ROS significantly decreased without any compensation (increase in PA) being made at Post-Camp in females. In conclusion, this finding, namely that ROS significantly decreased only at Post-Camp without any compensatory mechanism (increase in PA), would suggest that the training camp imposed greater loading on females than males. This consideration was supported by the atypical aspartate aminotransferase, leukocyte/neutrophil counts and C4 findings which were seen at Post-Camp only in females. Therefore, regularly examining neutrophil functions such as ROS and PA might be a good preventative measure against overtraining in athletes participating in training camps.

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Section: Discussioncontrasting

confidence: 61%

Measuring neutrophil functions might be a good predictive marker of overtraining in athletes

et al. 2008

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“…As for immunoglobulins and complements, there are many studies regarding exercise-mediated changes in these parameters, although the studies have presented conflicting results, showing increased, decreased or unchanged counts (32,(45)(46)(47). In the present study, one of the major reasons behind this mechanism may be the mobilization and recruitment of immunoglobulins and complements to the exercise-mediated denatured and damaged areas of muscle tissue, which had then entered the first inflammatory stage of the wound healing response.…”

Section: Discussioncontrasting

confidence: 49%

Effects of 2.5‐hour sumo training on serum opsonic activity

et al. 2009

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Sumo is a traditional Japanese sport, but the effect of actual daily training on neutrophil function is unknown. We evaluated the effect of sumo training on serum opsonic activity (SOA), which is one of the main neutrophil-related functions. Seventeen male university sumo wrestlers participated in the study. Changes in anthropometric parameters, concentrations of serum immunoglobulins (IgG, IgA and IgM), complements (C3 and C4), myogenic enzymes (lactate dehydrogenase, asparate aminotransferase, alanine aminotransferase and creatine kinase), white blood cell/neutrophil counts and SOA were measured immediately before and after actual daily training for 2.5 h. Compared with the pre-values, immunoglobulins and complements, myogenic enzymes and white blood cell/neutrophil counts significantly increased (p < 0.01 for all). As for SOA, the values of the peak height and the area under the curve significantly increased after the training when assessed using lucigenin as a chemiluminigenic probe (p < 0.01 for all), but showed no significant change when luminol was used as the chemiluminigenic probe. In conclusion, daily actual sumo training for 2.5 h increases SOA, thus possibly activating the reactive oxygen species production of neutrophils.

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“…The increased level of plasma IL-2 observed 16 h after the marathon (Study I) has also been observed by Pedersen (1991). Complement activation has been observed after prolonged and short-term exercise (Dufaux et al 1989a(Dufaux et al , 1991Camus et al 1994). Small amounts of complement C5a have been found to induce chemotaxis, and enhance phagocytosis and enzyme release from human polynuclear neutrophils in vitro (Rimmer and Horton 1991).…”

Section: Discussionmentioning

confidence: 68%

“…By contrast, the literature is much less prolific on the acute phase reactant responses (Liesen et al 1977, Dufaux et al 1984, 1989a and b and 1991Camus et al 1994) and the metabolic implications (Blomstrand et al 1988;Poortmans et al 1991) involved during prolonged exercise. The present investigation is an attempt to make a link between the lymphocyte changes, some acute phase proteins and cytokine responses and some plasma metabolic implications.…”

Section: Discussionmentioning

confidence: 86%

Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation

Castell

Poortmans

Leclercq

et al. 1996

European Journal of Applied Physiology

209

137

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Strenuous exercise may be associated with immune suppression. However, the underlying mechanism is not known. A decrease in the plasma level of glutamine, which is utilised at a high rate by cells of the immune system, and an increase in the plasma level of some cytokines may impair immune functions such as lymphocyte proliferation after prolonged, exhaustive exercise. In two separate studies of the Brussels marathon, using similar protocols, the time course of the changes in the plasma concentrations of some amino acids (glutamine, glutamate, alanine, tryptophan and branched chain amino acids), acute phase proteins and cytokines (interleukins IL-1 alpha, IL-2, IL-6, tumour necrosis factor type a) was measured in male athletes. The numbers of circulating leucocytes and lymphocytes were also measured. Amino acid and cytokine concentrations have not previously been measured concomitantly in marathon runners; the measurement of some of these parameters the morning after the marathon (16 h) is novel. Another novel feature is the provision of glutamine versus placebo to marathon runners participating in the second study. In both studies the plasma concentrations of glutamine, alanine and branched chain amino acids were decreased immediately after and 1 h after the marathon. Plasma concentrations of all amino acids returned to pre-exercise levels by 16 h after exercise. The plasma concentration of the complement anaphylotoxin C5a increased to abnormal levels after the marathon, presumably due to tissue damage activating the complement system. There was also an increase in plasma C-reactive protein 16 h after the marathon. The plasma levels of IL-1 alpha were unaffected by the exercise, while that of IL-2 was increased 16 h after exercise. Plasma IL-6 was increased markedly (approximately 45-fold) immediately after and at 1 h after exercise. Neopterine, a macrophage activation marker, was significantly increased post-exercise. There was a marked leucocytosis immediately after the marathon, which returned to normal 16 h later. At the same time there was a decrease in the number of T-lymphocytes, which was further reduced within 1 h to below pre-exercise levels. Glutamine supplementation, as administered in the second study, did not appear to have an effect upon lymphocyte distribution.

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Effect of a Short Maximal Physical Exercise on Coagulation, Fibrinolysis, and Complement System

Cited by 72 publications

References 9 publications

Measuring neutrophil functions might be a good predictive marker of overtraining in athletes

Measuring neutrophil functions might be a good predictive marker of overtraining in athletes

Effects of 2.5‐hour sumo training on serum opsonic activity

Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation

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